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Literature DB >> 106197

The effect of 5,8,11,14-eicosatetraynoic acid on lipid metabolism.

Abstract

The purpose of this presentation is to review the current state of knowledge regarding 5,8,11,14-eicosatetraynoic acid (ETYA, Ro 3-1428) and its effects on lipid metabolism. Accordingly, the topics discussed include hypocholesterolemic and dermatological studies involving ETYA in both animals and man, as well as the effects of ETYA on desaturase enzymes. Metabolic studies involving ETYA are also noted. Primary interest is focused on the effects of ETYA on selected processes of arachidonate metabolism, and the effect of ETYA on inflammation, platelet aggregation and tumor growth are discussed, keeping in mind the relevance of arachidonate metabolism to these processes.

Entities: Chemical Disease Species

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Year: 1979 PMID： 106197 DOI： 10.1007/bf02533870

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

53 in total

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Authors: J R Walker; M J Smith; A W Ford-Hutchinson
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25 in total

1. A possible role of lipoxygenase in the activation of vanilloid receptors by anandamide in the guinea-pig bronchus.

Authors: S J Craib; H C Ellington; R G Pertwee; R A Ross
Journal: Br J Pharmacol Date: 2001-09 Impact factor: 8.739

2. Identification and localization of an arachidonic acid-sensitive potassium channel in the cochlea.

Authors: Bernd H A Sokolowski; Yoshihisa Sakai; Margaret C Harvey; Dmytro E Duzhyy
Journal: J Neurosci Date: 2004-07-14 Impact factor: 6.167

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Authors: Adam Hendricson; Sheila Umlauf; Jae-Yeon Choi; Jose Thekkiniath; Yulia V Surovtseva; Kevin K Fuller; Todd B Reynolds; Dennis R Voelker; Choukri Ben Mamoun
Journal: J Biol Chem Date: 2019-06-21 Impact factor: 5.157

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Authors: J X Kang; A Leaf
Journal: Lipids Date: 1996-03 Impact factor: 1.880

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Authors: Y F Xiao; A M Gomez; J P Morgan; W J Lederer; A Leaf
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6. Reciprocal regulation of TREK-1 channels by arachidonic acid and CRH in mouse corticotropes.

Authors: Andy K Lee; James L Smart; Marcelo Rubinstein; Malcolm J Low; Amy Tse
Journal: Endocrinology Date: 2011-02-22 Impact factor: 4.736

7. Involvement of de Novo Protein Synthesis, Protein Kinase, Extracellular Ca2+, and Lipoxygenase in Arachidonic Acid Induction of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Genes and Isoprenoid Accumulation in Potato (Solanum tuberosum L.).

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Journal: Plant Physiol Date: 1994-04 Impact factor: 8.340