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Literature DB >> 823804

Anti-inflammatory drugs, prostaglandins and leucocyte migration.

J R Walker, M J Smith, A W Ford-Hutchinson.

Abstract

The action of some non-steroidal acidic anti-inflammatory drugs, aspirin, phenylbutazone and indomethacin, in reducing leucocyte migration into the exudates of inert porous sponges implanted subdermally in the rat has been shown to be distinct from their effect in reducing the content of prostaglandins in the exudates. It is concluded that a component of the anti-inflammatory and antirheumatic actions of the drugs is concerned with a mechanism other than inhibition of prostaglandin biosynthesis.

Entities: Chemical Species

Mesh：

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Year: 1976 PMID： 823804 DOI： 10.1007/BF01971577

Source DB: PubMed Journal: Agents Actions ISSN： 0065-4299

28 in total

1. Mode of action of an anti-inflammatory fraction from normal human plasma.

Authors: J R Walker; M J Smith; A W Ford-Hutchinson; F J Billimoria
Journal: Nature Date: 1975-04-03 Impact factor: 49.962

2. Effects of indomethacin on prostaglandin levels and leucocyte migration in an inflammatory exudate in vivo [proceedings].

Authors: A W Ford-Hutchinson; M J Smith; J R Walker
Journal: Br J Pharmacol Date: 1976-07 Impact factor: 8.739

3. Prostaglandin E-1: a potential mediator of the inflammatory response.

Authors: G Kaley; R Weiner
Journal: Ann N Y Acad Sci Date: 1971-04-30 Impact factor: 5.691

4. Prostaglandins as potentiators of increased vascular permeability in inflammation.

Authors: T J Williams; J Morley
Journal: Nature Date: 1973-11-23 Impact factor: 49.962

5. Effects of anti-inflammatory drugs on prostaglandin biosynthesis.

Authors: R Flower; R Gryglewski; K Herbaczyńska-Cedro; J R Vane
Journal: Nat New Biol Date: 1972-07-26

6. Proceedings: Prostaglandin production by rabbit peritoneal polymorphonuclear leukocytes in vitro.

Authors: G A Higgs; L J Youlten
Journal: Br J Pharmacol Date: 1972-02 Impact factor: 8.739

7. Quantitative determination of prostaglandins and malondialdehyde formed by the arachidonate oxygenase (prostaglandin synthetase) system of bovine seminal vesicle.

Authors: R J Flower; H S Cheung; D W Cushman
Journal: Prostaglandins Date: 1973-09

8. Prostaglandins and aspirin: an alternative view.

Authors: M J Smith
Journal: Agents Actions Date: 1975-10

9. Meiosis: a prostaglandin response that is not inhibited by aspirin.

Authors: P G Dellow; T S Miles
Journal: Br J Pharmacol Date: 1975-09 Impact factor: 8.739

10. A sensitive method for the assay of 5-hydroxytryptamine.

Authors: J R VANE
Journal: Br J Pharmacol Chemother Date: 1957-09

29 in total

1. In vitro effects of methotrexate on peripheral blood monocytes: modulation by folinic acid and S-adenosylmethionine.

Authors: G Nesher; T L Moore; R W Dorner
Journal: Ann Rheum Dis Date: 1991-09 Impact factor: 19.103

2. Nonsteroidal antiinflammatory drugs exert differential effects on neutrophil function and plasma membrane viscosity. Studies in human neutrophils and liposomes.

Authors: S B Abramson; B Cherksey; D Gude; J Leszczynska-Piziak; M R Philips; L Blau; G Weissmann
Journal: Inflammation Date: 1990-02 Impact factor: 4.092

3. Effects of etodolac, indomethacin and sodium salicylate on canine neutrophil function.

Authors: M K Thomsen; T Skak-Nielsen; I Ahnfelt-Rønne
Journal: Agents Actions Date: 1990-01

4. Clostridium difficile toxin A induces the release of neutrophil chemotactic factors from rat peritoneal macrophages: role of interleukin-1beta, tumor necrosis factor alpha, and leukotrienes.

Authors: M F Rocha; M E Maia; L R Bezerra; D M Lyerly; R L Guerrant; R A Ribeiro; A A Lima
Journal: Infect Immun Date: 1997-07 Impact factor: 3.441