| Literature DB >> 1260021 |
M H Fukami, H Holmsen, J Bauer.
Abstract
The relationship of a thrombin-induced burst in O2 consumption to lipid peroxidation in washed human platelets was investigated by measuring malonyldialdehyde, a by-product of endoperoxide degradation in platelets. The ratio of O2 consumed by malonyldialdehyde produced was approximately 7:1. Acetylsalicylate blocked the formation of malonyldialdehyde completely and partially inhibited the O2 burst induced by thrombin. 5,8,11,14-Eicosatetraynoic acid inhibited the O2 burst as well as the malonyldialdehyde formation completely. The release of [14C]serotonin was not affected by either inhibitor.Entities:
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Year: 1976 PMID： 1260021 DOI： 10.1016/0304-4165(76)90126-4
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002