Literature DB >> 10612599

Aptamers containing thymidine 3'-O-phosphorodithioates: synthesis and binding to nuclear factor-kappaB.

X Yang1, S Fennewald, B A Luxon, J Aronson, N K Herzog, D G Gorenstein.   

Abstract

Aptamers targeting NF-kappaB containing thymidine 3'-O-phosphorodithioates in selected positions of an oligonucleotide duplex were synthesized. Binding affinities to NF-kappaB varied with the number and positions of the dithioate backbone substitutions. One of the aptamers showed specific binding to a single NF-kappaB dimer in cell culture extracts.

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Year:  1999        PMID： 10612599     DOI： 10.1016/s0960-894x(99)00600-9

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  25 in total

1.  Construction and selection of bead-bound combinatorial oligonucleoside phosphorothioate and phosphorodithioate aptamer libraries designed for rapid PCR-based sequencing.

Authors:  Xianbin Yang; Suzanne E Bassett; Xin Li; Bruce A Luxon; Norbert K Herzog; Robert E Shope; Judy Aronson; Tarl W Prow; James F Leary; Romy Kirby; Andrew D Ellington; David G Gorenstein
Journal:  Nucleic Acids Res       Date:  2002-12-01       Impact factor: 16.971

2.  Strategies for the discovery of therapeutic aptamers.

Authors:  Xianbin Yang; Na Li; David G Gorenstein
Journal:  Expert Opin Drug Discov       Date:  2011-01       Impact factor: 6.098

3.  Label-Free Electrophoretic Mobility Shift Assay (EMSA) for Measuring Dissociation Constants of Protein-RNA Complexes.

Authors:  Minguk Seo; Li Lei; Martin Egli
Journal:  Curr Protoc Nucleic Acid Chem       Date:  2018-11-21

4.  Stereospecific Effects of Oxygen-to-Sulfur Substitution in DNA Phosphate on Ion Pair Dynamics and Protein-DNA Affinity.

Authors:  Dan Nguyen; Levani Zandarashvili; Mark A White; Junji Iwahara
Journal:  Chembiochem       Date:  2016-07-13       Impact factor: 3.164

5.  Selection of PD1/PD-L1 X-Aptamers.

Authors:  Hongyu Wang; Curtis H Lam; Xin Li; Derek L West; Xianbin Yang
Journal:  Biochimie       Date:  2017-09-11       Impact factor: 4.079

6.  Solid-Phase Synthesis of RNA Analogs Containing Phosphorodithioate Linkages.

Authors:  Xianbin Yang
Journal:  Curr Protoc Nucleic Acid Chem       Date:  2017-09-18

7.  Crystal structures of thrombin in complex with chemically modified thrombin DNA aptamers reveal the origins of enhanced affinity.

Authors:  Rafal Dolot; Curtis H Lam; Malgorzata Sierant; Qiang Zhao; Feng-Wu Liu; Barbara Nawrot; Martin Egli; Xianbin Yang
Journal:  Nucleic Acids Res       Date:  2018-05-18       Impact factor: 16.971

8.  Immunofluorescence assay and flow-cytometry selection of bead-bound aptamers.

Authors:  Xianbin Yang; Xin Li; Tarl W Prow; Lisa M Reece; Suzanne E Bassett; Bruce A Luxon; Norbert K Herzog; Judy Aronson; Robert E Shope; James F Leary; David G Gorenstein
Journal:  Nucleic Acids Res       Date:  2003-05-15       Impact factor: 16.971

9.  Attenuated and lethal variants of Pichindé virus induce differential patterns of NF-kappaB activation suggesting a potential target for novel therapeutics.

Authors:  Gavin C Bowick; Susan M Fennewald; Lihong Zhang; Xianbin Yang; Judith F Aronson; Robert E Shope; Bruce A Luxon; David G Gorenstein; Norbert K Herzog
Journal:  Viral Immunol       Date:  2009-12       Impact factor: 2.257

10.  Entropic Enhancement of Protein-DNA Affinity by Oxygen-to-Sulfur Substitution in DNA Phosphate.

Authors:  Levani Zandarashvili; Dan Nguyen; Kurtis M Anderson; Mark A White; David G Gorenstein; Junji Iwahara
Journal:  Biophys J       Date:  2015-09-01       Impact factor: 4.033
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