Literature DB >> 19951183

Attenuated and lethal variants of Pichindé virus induce differential patterns of NF-kappaB activation suggesting a potential target for novel therapeutics.

Gavin C Bowick1, Susan M Fennewald, Lihong Zhang, Xianbin Yang, Judith F Aronson, Robert E Shope, Bruce A Luxon, David G Gorenstein, Norbert K Herzog.   

Abstract

Lassa virus pathogenesis is believed to involve dysregulation of cytokines. We have previously shown nuclear factor-kappaB (NF-kappaB) inhibition using a BSL-2 model for Lassa fever. Here we further define the potential mechanism for NF-kappaB inhibition as involving increased levels of repressive p50/p50 homodimers, and suggest a novel therapeutic strategy that acts via modulation of host signaling.

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Year:  2009        PMID： 19951183      PMCID： PMC2883487          DOI： 10.1089/vim.2009.0034

Source DB:  PubMed          Journal:  Viral Immunol        ISSN： 0882-8245            Impact factor:   2.257


  31 in total

1.  Inhibition of the type I interferon response by the nucleoprotein of the prototypic arenavirus lymphocytic choriomeningitis virus.

Authors:  Luis Martínez-Sobrido; Elina I Zúñiga; Debralee Rosario; Adolfo García-Sastre; Juan Carlos de la Torre
Journal:  J Virol       Date:  2006-09       Impact factor: 5.103

2.  Discrimination between RelA and RelB transcriptional regulation by a dominant negative mutant of IkappaBalpha.

Authors:  V Ferreira; N Tarantino; M Körner
Journal:  J Biol Chem       Date:  1998-01-02       Impact factor: 5.157

3.  Interferon response in the guinea pig infected with Junín virus.

Authors:  C B Dejean; B L Ayerra; A R Teyssié
Journal:  J Med Virol       Date:  1987-09       Impact factor: 2.327

4.  Exploring kinase inhibitors as therapies for human arenavirus infections.

Authors:  Eric M Vela; Gavin C Bowick; Norbert K Herzog; Judith F Aronson
Journal:  Future Virol       Date:  2008       Impact factor: 1.831

5.  Markedly elevated levels of interferon (IFN)-gamma, IFN-alpha, interleukin (IL)-2, IL-10, and tumor necrosis factor-alpha associated with fatal Ebola virus infection.

Authors:  F Villinger; P E Rollin; S S Brar; N F Chikkala; J Winter; J B Sundstrom; S R Zaki; R Swanepoel; A A Ansari; C J Peters
Journal:  J Infect Dis       Date:  1999-02       Impact factor: 5.226

6.  African swine fever virus infection induces tumor necrosis factor alpha production: implications in pathogenesis.

Authors:  M Gómez del Moral; E Ortuño; P Fernández-Zapatero; F Alonso; C Alonso; A Ezquerra; J Domínguez
Journal:  J Virol       Date:  1999-03       Impact factor: 5.103

7.  Tumor necrosis factor and the pathogenesis of Pichinde virus infection in guinea pigs.

Authors:  J F Aronson; N K Herzog; T R Jerrells
Journal:  Am J Trop Med Hyg       Date:  1995-03       Impact factor: 2.345

8.  Molecular mechanisms of interleukin-10-mediated inhibition of NF-kappaB activity: a role for p50.

Authors:  F Driessler; K Venstrom; R Sabat; K Asadullah; A J Schottelius
Journal:  Clin Exp Immunol       Date:  2004-01       Impact factor: 4.330

9.  Early blood profiles of virus infection in a monkey model for Lassa fever.

Authors:  Mahmoud M Djavani; Oswald R Crasta; Juan Carlos Zapata; Zhangjun Fei; Otto Folkerts; Bruno Sobral; Mark Swindells; Joseph Bryant; Harry Davis; C David Pauza; Igor S Lukashevich; Rasha Hammamieh; Marti Jett; Maria S Salvato
Journal:  J Virol       Date:  2007-05-23       Impact factor: 5.103

10.  Gene expression in primate liver during viral hemorrhagic fever.

Authors:  Mahmoud Djavani; Oswald R Crasta; Yan Zhang; Juan Carlos Zapata; Bruno Sobral; Melissa G Lechner; Joseph Bryant; Harry Davis; Maria S Salvato
Journal:  Virol J       Date:  2009-02-12       Impact factor: 4.099
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  10 in total

Review 1.  Vaccine and adjuvant design for emerging viruses: mutations, deletions, segments and signaling.

Authors:  Gavin C Bowick; Alexander J McAuley
Journal:  Bioeng Bugs       Date:  2011-05-01

2.  Arenavirus nucleoproteins prevent activation of nuclear factor kappa B.

Authors:  W W Shanaka I Rodrigo; Emilio Ortiz-Riaño; Christelle Pythoud; Stefan Kunz; Juan C de la Torre; Luis Martínez-Sobrido
Journal:  J Virol       Date:  2012-05-23       Impact factor: 5.103

3.  Interference with intraepithelial TNF-α signaling inhibits CD8(+) T-cell-mediated lung injury in influenza infection.

Authors:  Anon Srikiatkhachorn; Jyothi Chintapalli; Jun Liu; Mohammad Jamaluddin; Kevin S Harrod; Jeffrey A Whitsett; Richard I Enelow; Chilakamarti V Ramana
Journal:  Viral Immunol       Date:  2010-12       Impact factor: 2.257

Review 4.  The search for animal models for Lassa fever vaccine development.

Authors:  Igor S Lukashevich
Journal:  Expert Rev Vaccines       Date:  2013-01       Impact factor: 5.217

Review 5.  Comparative pathogenesis and systems biology for biodefense virus vaccine development.

Authors:  Gavin C Bowick; Alan D T Barrett
Journal:  J Biomed Biotechnol       Date:  2010-06-06

6.  Proteomic analysis of Pichindé virus infection identifies differential expression of prothymosin-alpha.

Authors:  Gavin C Bowick; Kizhake V Soman; He Wang; Judith F Aronson; Bruce A Luxon; Lee O Lomas; David G Gorenstein; Norbert K Herzog
Journal:  J Biomed Biotechnol       Date:  2010-04-18

7.  Meta-analysis of high-throughput datasets reveals cellular responses following hemorrhagic fever virus infection.

Authors:  Gavin C Bowick; Alexander J McAuley
Journal:  Viruses       Date:  2011-05-12       Impact factor: 5.048

Review 8.  Innate immune response to arenaviral infection: a focus on the highly pathogenic New World hemorrhagic arenaviruses.

Authors:  Takaaki Koma; Cheng Huang; Olga A Kolokoltsova; Allan R Brasier; Slobodan Paessler
Journal:  J Mol Biol       Date:  2013-09-26       Impact factor: 5.469

Review 9.  A systems biology starter kit for arenaviruses.

Authors:  Magali E Droniou-Bonzom; Paula M Cannon
Journal:  Viruses       Date:  2012-12       Impact factor: 5.048

10.  An attenuated Lassa vaccine in SIV-infected rhesus macaques does not persist or cause arenavirus disease but does elicit Lassa virus-specific immunity.

Authors:  Juan C Zapata; Bhawna Poonia; Joseph Bryant; Harry Davis; Eugene Ateh; Lanea George; Oswald Crasta; Yan Zhang; Tom Slezak; Crystal Jaing; C David Pauza; Marco Goicochea; Dmitry Moshkoff; Igor S Lukashevich; Maria S Salvato
Journal:  Virol J       Date:  2013-02-12       Impact factor: 4.099
  10 in total

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