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Literature DB >> 10607476

Prooxidant activity of flavonoids: copper-dependent strand breaks and the formation of 8-hydroxy-2'-deoxyguanosine in DNA.

M Yoshino¹, M Haneda, M Naruse, K Murakami.

Abstract

The naturally occurring flavonoids caused strand scission of DNA in the presence of copper ion. Flavonoids such as myricetin, baicalein, and quercetin as well as ascorbic acid cleaved plasmid pBR322 DNA and calf thymus DNA potently. Addition of catalase protected DNA from the strand breaks caused by flavonoids. Treatment of calf thymus DNA with these flavonoids or ascorbate plus copper produced 8-hydroxy-2'-deoxyguanosine. Cuprous ion reduced by flavonoids and ascorbic acid may play a key role in the oxidative cleavage of DNA and the formation of base adduct. Mutagenic and carcinogenic action of flavonoids may be explained by the prooxidant effects of the compounds. Copyright 1999 Academic Press.

Entities: Chemical Disease Gene Species

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Year: 1999 PMID： 10607476 DOI： 10.1006/mgme.1999.2901

Source DB: PubMed Journal: Mol Genet Metab ISSN： 1096-7192 Impact factor: 4.797

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Cited

12 in total

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2. A real-time QCM-D approach to monitoring mammalian DNA damage using DNA adsorbed to a polyelectrolyte surface.

Authors: Robert J Rawle; Malkiat S Johal; Cynthia R D Selassie
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3. Flavonoid detection in hydroethanolic extract of Pouteria torta (Sapotaceae) leaves by HPLC-DAD and the determination of its mutagenic activity.

Authors: Daryne L M G Costa; Daniel Rinaldo; Eliana A Varanda; Juliana F de Sousa; Ana L M Nasser; Ana C Z Silva; Débora C Baldoqui; Wagner Vilegas; Lourdes Campaner dos Santos
Journal: J Med Food Date: 2014-07-23 Impact factor: 2.786

4. DNA binding and oxidative DNA damage induced by a quercetin copper(II) complex: potential mechanism of its antitumor properties.

Authors: Jun Tan; Bochu Wang; Liancai Zhu
Journal: J Biol Inorg Chem Date: 2009-03-04 Impact factor: 3.358

Prooxidant activity of flavonoids: copper-dependent strand breaks and the formation of 8-hydroxy-2'-deoxyguanosine in DNA.

1. Polyphenol effects on CuO-nanoparticle-mediated DNA damage, reactive oxygen species generation, and fibroblast cell death.

2. A real-time QCM-D approach to monitoring mammalian DNA damage using DNA adsorbed to a polyelectrolyte surface.

3. Flavonoid detection in hydroethanolic extract of Pouteria torta (Sapotaceae) leaves by HPLC-DAD and the determination of its mutagenic activity.

4. DNA binding and oxidative DNA damage induced by a quercetin copper(II) complex: potential mechanism of its antitumor properties.

5. Quercetin and cancer chemoprevention.

Review 6. Natural Compounds Modulating Mitochondrial Functions.

Review 7. Polyphenols with Anti-Amyloid β Aggregation Show Potential Risk of Toxicity Via Pro-Oxidant Properties.

8. Antioxidant and Pro-Oxidant Activities of Melatonin in the Presence of Copper and Polyphenols In Vitro and In Vivo.

9. Generation of reactive oxygen species by hydroxypyridone compound/iron complexes.

10. Neurotoxic Effect of Flavonol Myricetin in the Presence of Excess Copper.