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Literature DB >> 10606639

APOBEC-1 dependent cytidine to uridine editing of apolipoprotein B RNA in yeast.

G S Dance¹, M P Sowden, Y Yang, H C Smith.

Abstract

Cytidine to uridine editing of apolipoprotein B (apoB) mRNA requires the cytidine deaminase APOBEC-1 as well as a tripartite sequence motif flanking a target cytidine in apoB mRNA and an undefined number of auxiliary proteins that mediate RNA recognition and determine site-specific editing. Yeast engineered to express APOBEC-1 and apoB mRNA supported editing under conditions of late log phase growth and stationary phase. The cis -acting sequence requirements and the intracellular distribution of APOBEC-1 in yeast were similar to those described in mammalian cells. These findings suggest that auxiliary protein functions necessary for the assembly of editing complexes, or 'editosomes', are expressed in yeast and that the distribution of editing activity is to the cell nucleus.

Entities: Chemical Species

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Year: 2000 PMID： 10606639 PMCID： PMC102520 DOI： 10.1093/nar/28.2.424

Source DB: PubMed Journal: Nucleic Acids Res ISSN： 0305-1048 Impact factor: 16.971

41 in total

1. Characterization of the transcriptional potency of sub-elements of the UAS of the yeast PGK gene in a PGK mini-promoter.

Authors: C A Stanway; A Chambers; A J Kingsman; S M Kingsman
Journal: Nucleic Acids Res Date: 1989-11-25 Impact factor: 16.971

2. A 40 kilodalton rat liver nuclear protein binds specifically to apolipoprotein B mRNA around the RNA editing site.

Authors: P P Lau; S H Chen; J C Wang; L Chan
Journal: Nucleic Acids Res Date: 1990-10-11 Impact factor: 16.971

3. Quantitation of endogenous liver apolipoprotein B mRNA editing.

Authors: J W Backus; M J Eagleton; S G Harris; C E Sparks; J D Sparks; H C Smith
Journal: Biochem Biophys Res Commun Date: 1990-07-31 Impact factor: 3.575

4. Characterization of the apolipoprotein B mRNA editing activity in enterocyte extracts.

Authors: D M Driscoll; E Casanova
Journal: J Biol Chem Date: 1990-12-15 Impact factor: 5.157

5. A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine.

Authors: L M Powell; S C Wallis; R J Pease; Y H Edwards; T J Knott; J Scott
Journal: Cell Date: 1987-09-11 Impact factor: 41.582

6. Apolipoprotein B mRNA editing is an intranuclear event that occurs posttranscriptionally coincident with splicing and polyadenylation.

Authors: P P Lau; W J Xiong; H J Zhu; S H Chen; L Chan
Journal: J Biol Chem Date: 1991-10-25 Impact factor: 5.157

7. Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon.

Authors: S H Chen; G Habib; C Y Yang; Z W Gu; B R Lee; S A Weng; S R Silberman; S J Cai; J P Deslypere; M Rosseneu
Journal: Science Date: 1987-10-16 Impact factor: 47.728

8. Sequence requirements for the editing of apolipoprotein B mRNA.

Authors: R R Shah; T J Knott; J E Legros; N Navaratnam; J C Greeve; J Scott
Journal: J Biol Chem Date: 1991-09-05 Impact factor: 5.157

9. Apolipoprotein B mRNA sequences 3' of the editing site are necessary and sufficient for editing and editosome assembly.

Authors: J W Backus; H C Smith
Journal: Nucleic Acids Res Date: 1991-12-25 Impact factor: 16.971

APOBEC-1 dependent cytidine to uridine editing of apolipoprotein B RNA in yeast.

1. Characterization of the transcriptional potency of sub-elements of the UAS of the yeast PGK gene in a PGK mini-promoter.

2. A 40 kilodalton rat liver nuclear protein binds specifically to apolipoprotein B mRNA around the RNA editing site.

3. Quantitation of endogenous liver apolipoprotein B mRNA editing.

4. Characterization of the apolipoprotein B mRNA editing activity in enterocyte extracts.

5. A novel form of tissue-specific RNA processing produces apolipoprotein-B48 in intestine.

6. Apolipoprotein B mRNA editing is an intranuclear event that occurs posttranscriptionally coincident with splicing and polyadenylation.

7. Apolipoprotein B-48 is the product of a messenger RNA with an organ-specific in-frame stop codon.

8. Sequence requirements for the editing of apolipoprotein B mRNA.

9. Apolipoprotein B mRNA sequences 3' of the editing site are necessary and sufficient for editing and editosome assembly.

10. In vitro apolipoprotein B mRNA editing: identification of a 27S editing complex.

1. The cytidine deaminases AID and APOBEC-1 exhibit distinct functional properties in a novel yeast selectable system.

2. Mutator effects and mutation signatures of editing deaminases produced in bacteria and yeast.

3. Identification of the yeast cytidine deaminase CDD1 as an orphan C-->U RNA editase.

4. Commitment of apolipoprotein B RNA to the splicing pathway regulates cytidine-to-uridine editing-site utilization.

5. Biochemical and molecular characterization of two cytidine deaminases in the nematode Caenorhabditis elegans.