Literature DB >> 1060077

Regulation of synthesis of hepatic fatty acid synthetase: binding of fatty acid synthetase antibodies to polysomes.

A W Alberts, A W Strauss, S Hennessy, P R Vagelos.   

Abstract

Mammalian fatty acid synthetase was shown to be composed of two peptides, molecular weight 240,000, after dissociation with sodium dodecyl sulfate. Rat liver polysomes that synthesize fatty acid synthetase were identified by sucrose gradient analysis of polysomes that had been reacted with 125I-labeled antibody against fatty acid synthetase. The binding of 125I-labeled antibody to polysomes was found to correlate with the rate of hepatic fatty acid synthesis in various nutritional conditions.

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Year:  1975        PMID： 1060077      PMCID： PMC433116          DOI： 10.1073/pnas.72.10.3956

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

1.  A PREPARATIVE METHOD FOR THE SEPARATION OF 7S GAMMA GLOBULIN FROM HUMAN SERUM.

Authors:  J S BAUMSTARK; R J LAFFIN; W A BARDAWIL
Journal:  Arch Biochem Biophys       Date:  1964-12       Impact factor: 4.013

2.  Mammalian acyl carrier protein. Dissociation of the acyl carrier protein subunit from dog liver fatty acid synthetase complex.

Authors:  D A Roncari
Journal:  J Biol Chem       Date:  1974-11-10       Impact factor: 5.157

3.  Specificity of the binding of antibodies to polysomes in hen oviduct.

Authors:  C González; R Palacios; R T Schimke
Journal:  Biochim Biophys Acta       Date:  1974-11-06

4.  Identification and isolation of ovalbumin-synthesizing polysomes. II. Quantification and immunoprecipitation of polysomes.

Authors:  R D Palmiter; R Palacios; R T Schimke
Journal:  J Biol Chem       Date:  1972-05-25       Impact factor: 5.157

5.  Identification and isolation of ovalbumin-synthesizing polysomes. I. Specific binding of 125 I-anti-ovalbumin to polysomes.

Authors:  R Palacios; R D Palmiter; R T Schimke
Journal:  J Biol Chem       Date:  1972-04-25       Impact factor: 5.157

6.  Regulation of mammalian fatty-acid synthetase. The roles of carbohydrate and insulin.

Authors:  J J Volpe; P R Vagelos
Journal:  Proc Natl Acad Sci U S A       Date:  1974-03       Impact factor: 11.205

Review 7.  Saturated fatty acid biosynthesis and its regulation.

Authors:  J J Volpe; P R Vagelos
Journal:  Annu Rev Biochem       Date:  1973       Impact factor: 23.643

8.  Crotonyl coenzyme A reductase activity of bovine mammary fatty acid synthetase.

Authors:  S K Maitra; S Kumar
Journal:  J Biol Chem       Date:  1974-01-10       Impact factor: 5.157

9.  Regulation of lipid synthesis in cultured animal cells.

Authors:  A W Alberts; K Ferguson; S Hennessy; P R Vagelos
Journal:  J Biol Chem       Date:  1974-08-25       Impact factor: 5.157

10.  Control of the synthesis of fatty-acid synthetase in rat liver by insulin, glucagon, and adenosine 3':5' cyclic monophosphate.

Authors:  M R Lakshmanan; C M Nepokroeff; J W Porter
Journal:  Proc Natl Acad Sci U S A       Date:  1972-12       Impact factor: 11.205
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  16 in total

1.  Specific release of the thioesterase component of the fatty acid synthetase multienzyme complex by limited trypsinization.

Authors:  S Smith; E Agradi; L Libertini; K N Dileepan
Journal:  Proc Natl Acad Sci U S A       Date:  1976-04       Impact factor: 11.205

2.  Dietary and hormonal regulation of the content of acetyl coenzyme A carboxylase-synthesizing polysomes in rat liver.

Authors:  S Nakanishi; T Tanabe; S Horikawa; S Numa
Journal:  Proc Natl Acad Sci U S A       Date:  1976-07       Impact factor: 11.205

3.  Induction of fatty acid synthetase and acetyl-CoA carboxylase by isolated rat liver cells.

Authors:  J W Porter; T L Swenson
Journal:  Mol Cell Biochem       Date:  1983       Impact factor: 3.396

4.  Effect of ethanol administration on fatty acid desaturation.

Authors:  A M Nervi; R O Peluffo; R R Brenner; A I Leikin
Journal:  Lipids       Date:  1980-04       Impact factor: 1.880

5.  Orally administration of Neolentinus lepideus extracts attenuated ethanol induced accumulation of hepatic lipid in mice.

Authors:  Ki Moon Park; Ye Na Park; Oh Yun Kwon; Seung Ho Lee
Journal:  Food Sci Biotechnol       Date:  2018-08-14       Impact factor: 2.391

6.  Adipocyte-Specific Modulation of KLF14 Expression in Mice Leads to Sex-Dependent Impacts on Adiposity and Lipid Metabolism.

Authors:  Qianyi Yang; Jameson Hinkle; Jordan N Reed; Redouane Aherrahrou; Zhiwen Xu; Thurl E Harris; Erin J Stephenson; Kiran Musunuru; Susanna R Keller; Mete Civelek
Journal:  Diabetes       Date:  2022-04-01       Impact factor: 9.461

7.  Maternal/fetal metabolomes appear to mediate the impact of arsenic exposure on birth weight: A pilot study.

Authors:  Yongyue Wei; Qianwen Shi; Zhaoxi Wang; Ruyang Zhang; Li Su; Quazi Quamruzzaman; Mahmuder Rahman; Feng Chen; David C Christiani
Journal:  J Expo Sci Environ Epidemiol       Date:  2016-12-14       Impact factor: 5.563

8.  Dietary-induced pre-translational control of rat fatty acid synthase.

Authors:  T Laux; M Schweizer
Journal:  Biochem J       Date:  1990-03-15       Impact factor: 3.857

9.  Translation of rat liver fatty acid synthetase mRNA in a cell-free system derived from wheat germ.

Authors:  P K Flick; J Chen; A W Alberts; P R Vagelos
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

10.  Rat liver preproalbumin: in vitro synthesis and partial amino acid sequence.

Authors:  A W Strauss; A M Donohue; C D Bennett; J A Rodkey; A W Alberts
Journal:  Proc Natl Acad Sci U S A       Date:  1977-04       Impact factor: 11.205
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