Literature DB >> 4345502

Control of the synthesis of fatty-acid synthetase in rat liver by insulin, glucagon, and adenosine 3':5' cyclic monophosphate.

M R Lakshmanan, C M Nepokroeff, J W Porter.   

Abstract

The usual increase in the activity of liver fatty-acid synthetase that occurs on refeeding of a fat-free diet to previously fasted rats is abolished in diabetic animals. Insulin specifically restores this increase by enhancement of the rate of synthesis of fatty-acid synthetase. However, glucagon and cyclic AMP inhibit the increase in the activity of fatty-acid synthetase. Therefore, the concentration of fatty-acid synthetase in rat liver is under the control of the relative concentrations of insulin and glucagon.

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Year:  1972        PMID： 4345502      PMCID： PMC389810          DOI： 10.1073/pnas.69.12.3516

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  18 in total

Review 1.  The role of cyclic AMP in the control of carbohydrate metabolism.

Authors:  E W Sutherland; G A Robison
Journal:  Diabetes       Date:  1969-12       Impact factor: 9.461

2.  Induction of hepatic enzyme synthesis in vivo by adenosine 3', 5'-monophosphate.

Authors:  W D Wicks; F T Kenney; K L Lee
Journal:  J Biol Chem       Date:  1969-11-10       Impact factor: 5.157

3.  Studies of the diabetogenic action of streptozotocin.

Authors:  A Junod; A E Lambert; L Orci; R Pictet; A E Gonet; A E Renold
Journal:  Proc Soc Exp Biol Med       Date:  1967-10

4.  Role of adenosine 3',5'-monophosphate in the effects of insulin and anti-insulin serum on liver metabolism.

Authors:  L S Jefferson; J H Exton; R W Butcher; E W Sutherland; C R Park
Journal:  J Biol Chem       Date:  1968-03-10       Impact factor: 5.157

5.  The effects of nutritional and hormonal factors on the fatty acid synthetase level of rat liver.

Authors:  D N Burton; J M Collins; A L Kennan; J W Porter
Journal:  J Biol Chem       Date:  1969-08-25       Impact factor: 5.157

6.  Acetyl coenzyme A carboxylase. The roles of synthesis and degradation in regulation of enzyme levels in rat liver.

Authors:  P W Majerus; E Kilburn
Journal:  J Biol Chem       Date:  1969-11-25       Impact factor: 5.157

7.  Glucose repression and induction of enzyme synthesis in rat liver.

Authors:  H C Pitot; C Peraino; N Pries; A L Kennan
Journal:  Adv Enzyme Regul       Date:  1964

8.  Studies on biosynthesis and catabolism of insulin.

Authors:  S R Wagle
Journal:  Biochim Biophys Acta       Date:  1965-10-18

9.  Regulation of tyrosine alpha-ketoglutarate transaminase in rat liver. VI. Induction by pancreatic hormones.

Authors:  D Holten; F T Kenney
Journal:  J Biol Chem       Date:  1967-10-10       Impact factor: 5.157

10.  Diabetogenic action of streptozotocin: relationship of dose to metabolic response.

Authors:  A Junod; A E Lambert; W Stauffacher; A E Renold
Journal:  J Clin Invest       Date:  1969-11       Impact factor: 14.808
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  34 in total

1.  Regulation of synthesis of hepatic fatty acid synthetase: binding of fatty acid synthetase antibodies to polysomes.

Authors:  A W Alberts; A W Strauss; S Hennessy; P R Vagelos
Journal:  Proc Natl Acad Sci U S A       Date:  1975-10       Impact factor: 11.205

Review 2.  Fatty acid synthase and liver triglyceride metabolism: housekeeper or messenger?

Authors:  Anne P L Jensen-Urstad; Clay F Semenkovich
Journal:  Biochim Biophys Acta       Date:  2011-10-08

3.  Genetic regulation of galactokinase in Tetrahymena by cyclic AMP glucose, and epinephrine.

Authors:  C T Roberts; D E Morse
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

4.  Cloning of cDNA to rat mammary-gland fatty acid synthase mRNA. Evidence for the expression of two mRNA species during lactation.

Authors:  M Braddock; D G Hardie
Journal:  Biochem J       Date:  1988-01-15       Impact factor: 3.857

5.  Combined treatment of sodium orthovanadate and Momordica charantia fruit extract prevents alterations in lipid profile and lipogenic enzymes in alloxan diabetic rats.

Authors:  Umesh C S Yadav; K Moorthy; Najma Z Baquer
Journal:  Mol Cell Biochem       Date:  2005-01       Impact factor: 3.396

6.  Liver-specific mRNA for Insig-2 down-regulated by insulin: implications for fatty acid synthesis.

Authors:  Daisuke Yabe; Ryutaro Komuro; Guosheng Liang; Joseph L Goldstein; Michael S Brown
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-06       Impact factor: 11.205

7.  Regulation of mammalian fatty-acid synthetase. The roles of carbohydrate and insulin.

Authors:  J J Volpe; P R Vagelos
Journal:  Proc Natl Acad Sci U S A       Date:  1974-03       Impact factor: 11.205

8.  Stimulation of hepatic lipogenesis and acetyl-coenzyme A carboxylase by vasopressin.

Authors:  F Assimacopoulos-Jeannet; R M Denton; B Jeanrenaud
Journal:  Biochem J       Date:  1981-09-15       Impact factor: 3.857

9.  Levels of cyclic 3'-5' -adenosine monophosphate (cAMP) in maintenance cultures of rat hepatocytes in response to insulin and glucagon.

Authors:  M J Geelen; W J Vaartjes
Journal:  Lipids       Date:  1977-07       Impact factor: 1.880

Review 10.  The potential of ¹¹C-acetate PET for monitoring the Fatty acid synthesis pathway in Tumors.

Authors:  Laura M Deford-Watts; Akiva Mintz; Steven J Kridel
Journal:  Curr Pharm Biotechnol       Date:  2013       Impact factor: 2.837
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