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Literature DB >> 7374380

Effect of ethanol administration on fatty acid desaturation.

A M Nervi, R O Peluffo, R R Brenner, A I Leikin.

Abstract

The effect of ethanol on the fatty acid desaturation by rat liver has been studied using liquid diets of different composition. Acute ethanol administration increased triacylglycerols of total liver lipids, but did not modify significantly the lipidic composition of microsomes. The delta 6 and delta 5 desaturases were inhibited by ethanol whereas the delta 9 desaturase and fatty acid synthetase were apparently modified only by diet composition. NADH-cytochrome (cyt.) c reductase was partially inhibited, whereas NADH-cyt. b5 reductase remained practically unaltered and NADPH-cyt. c reductase activity was enhanced. Decreased electrons supplied by the microsomal cyt. b5 electron transport chain would not be the reason for the inhibition of delta 6 and delta 5 desaturases by ethanol.

Entities: Chemical Species

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Year: 1980 PMID： 7374380 DOI： 10.1007/bf02535837

Source DB: PubMed Journal: Lipids ISSN： 0024-4201 Impact factor: 1.880

21 in total

1. EFFECTS OF PROLONGED ETHANOL INTAKE: PRODUCTION OF FATTY LIVER DESPITE ADEQUATE DIETS.

Authors: C S LIEBER; D P JONES; L M DECARLI
Journal: J Clin Invest Date: 1965-06 Impact factor: 14.808

2. Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid.

Authors: H G Enoch; A Catalá; P Strittmatter
Journal: J Biol Chem Date: 1976-08-25 Impact factor: 5.157

3. Effect of protein and insulin on linoleic acid desaturation of normal and diabetic rats.

Authors: R O Peluffo; N T De Gomez Dumm; M J De Alaniz; R R Brenner
Journal: J Nutr Date: 1971-08 Impact factor: 4.798

4. Reconstitution of the microsomal ethanol-oxidizing system. Qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption.

Authors: K Ohnishi; C S Lieber
Journal: J Biol Chem Date: 1977-10-25 Impact factor: 5.157

5. The dietary control of the microsomal stearyl CoA desaturation enzyme system in rat liver.

Authors: N Oshino; R Sato
Journal: Arch Biochem Biophys Date: 1972-04 Impact factor: 4.013

6. The oxidative desaturation of unsaturated fatty acids in animals.

Authors: R R Brenner
Journal: Mol Cell Biochem Date: 1974-03-08 Impact factor: 3.396

7. Effect of dietary linoleate on synthesis and degradation of fatty acid synthetase from rat liver.

Authors: P K Flick; J Chen; P R Vagelos
Journal: J Biol Chem Date: 1977-06-25 Impact factor: 5.157

8. Differential responses to fasting and subsequent feeding by microsomal systems of rat liver: 6- and 9-desaturation of fatty acids.

Authors: C A Inkpen; R A Harris; F W Quackenbush
Journal: J Lipid Res Date: 1969-05 Impact factor: 5.922

9. Evidence for participation of cytochrome b5 in microsomal delta-6 desaturation of fatty acids.

Authors: T C Lee; R C Baker; N Stephens; F Snyder
Journal: Biochim Biophys Acta Date: 1977-10-24

10. Oxidative desaturation of eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid: comparison of different diets on oxidative desaturation at the 5,6 and 6,7 positions.

Authors: J C Castuma; A Catala; R R Brenner
Journal: J Lipid Res Date: 1972-11 Impact factor: 5.922

21 in total

1. Influence of dietary fats on pancreatic phospholipids of chronically ethanol-treated rats.

Authors: T Cronholm; A Neri; F Karpe; T Curstedt
Journal: Lipids Date: 1988-09 Impact factor: 1.880

2. Essential fatty acids and peptic ulcer disease.

Authors: U N Das; D N Reddy; P N Rao; V Radha
Journal: Gut Date: 1987-07 Impact factor: 23.059

3. The prevention of alcoholic fatty liver using dietary supplements: dihydroxyacetone, pyruvate and riboflavin compared to arachidonic acid in pair-fed rats.

Authors: S C Goheen; E E Pearson; E C Larkin; G A Rao
Journal: Lipids Date: 1981-01 Impact factor: 1.880

Effect of ethanol administration on fatty acid desaturation.

1. EFFECTS OF PROLONGED ETHANOL INTAKE: PRODUCTION OF FATTY LIVER DESPITE ADEQUATE DIETS.

2. Mechanism of rat liver microsomal stearyl-CoA desaturase. Studies of the substrate specificity, enzyme-substrate interactions, and the function of lipid.

3. Effect of protein and insulin on linoleic acid desaturation of normal and diabetic rats.

4. Reconstitution of the microsomal ethanol-oxidizing system. Qualitative and quantitative changes of cytochrome P-450 after chronic ethanol consumption.

5. The dietary control of the microsomal stearyl CoA desaturation enzyme system in rat liver.

6. The oxidative desaturation of unsaturated fatty acids in animals.

7. Effect of dietary linoleate on synthesis and degradation of fatty acid synthetase from rat liver.

8. Differential responses to fasting and subsequent feeding by microsomal systems of rat liver: 6- and 9-desaturation of fatty acids.

9. Evidence for participation of cytochrome b5 in microsomal delta-6 desaturation of fatty acids.

10. Oxidative desaturation of eicosa-8,11-dienoic acid to eicosa-5,8,11-trienoic acid: comparison of different diets on oxidative desaturation at the 5,6 and 6,7 positions.

1. Influence of dietary fats on pancreatic phospholipids of chronically ethanol-treated rats.

2. Essential fatty acids and peptic ulcer disease.

3. The prevention of alcoholic fatty liver using dietary supplements: dihydroxyacetone, pyruvate and riboflavin compared to arachidonic acid in pair-fed rats.

Review 4. n-3 fatty acid enrichment of edible tissue of poultry: a review.

5. Interactive effects of prenatal ethanol and N-3 fatty acid supplementation on brain development in mice.

6. Influence of testosterone administration on the biosynthesis of unsaturated fatty acids in male and female rats.

7. Relation between consumption of alcohol and fatty acids esterifying serum cholesterol in healthy men.

8. Growth hormone and liver mitochondria: effects on phospholipid composition and fatty acyl distribution.

9. Volatile alkanes produced by erythrocytes: an assay for in vitro studies on lipid peroxidation.

10. Effects of red wine consumption on kidney FA composition.