Literature DB >> 10600692

Nuclear receptor regulation of cholesterol and bile acid metabolism.

J J Repa1, D J Mangelsdorf.   

Abstract

The metabolism of cholesterol and bile acids is transcriptionally regulated by classic feedforward and feedback signaling pathways. The mechanisms underlying this regulation have recently been elucidated by the characterization of three classes of orphan nuclear receptors. Furthermore, the study of these receptors suggests their potential as targets for new drug therapies.

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Year:  1999        PMID： 10600692     DOI： 10.1016/s0958-1669(99)00031-2

Source DB:  PubMed          Journal:  Curr Opin Biotechnol        ISSN： 0958-1669            Impact factor:   9.740


  30 in total

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2.  Identification of macrophage liver X receptors as inhibitors of atherosclerosis.

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3.  Intracerebroventricular leptin regulates hepatic cholesterol metabolism.

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Journal:  Biochem J       Date:  2004-04-15       Impact factor: 3.857

4.  Therapeutic potential of cyclodextrins in the treatment of Niemann-Pick type C disease.

Authors:  Benny Liu
Journal:  Clin Lipidol       Date:  2012-06

5.  Activation of liver X receptors and retinoid X receptors prevents bacterial-induced macrophage apoptosis.

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6.  Nutritional factors and progenitor cell differentiation.

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Review 7.  The Farnesoid X Receptor (FXR) as modulator of bile acid metabolism.

Authors:  Folkert Kuipers; Thierry Claudel; Ekkehard Sturm; Bart Staels
Journal:  Rev Endocr Metab Disord       Date:  2004-12       Impact factor: 6.514

8.  Bioavailability and hypoglycemic activity of the semisynthetic bile acid salt, sodium 3alpha,7alpha-dihydroxy-12-oxo-5beta-cholanate, in healthy and diabetic rats.

Authors:  M Mikov; N S Boni; H Al-Salami; K Kuhajda; S Kevresan; S Golocorbin-Kon; J P Fawcett
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2007 Jan-Mar       Impact factor: 2.441

9.  Androgen deprivation by activating the liver X receptor.

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10.  Cyclodextrin overcomes the transport defect in nearly every organ of NPC1 mice leading to excretion of sequestered cholesterol as bile acid.

Authors:  Benny Liu; Charina M Ramirez; Anna M Miller; Joyce J Repa; Stephen D Turley; John M Dietschy
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