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Literature DB >> 14984364

Intracerebroventricular leptin regulates hepatic cholesterol metabolism.

Sonya Vanpatten¹, George B Karkanias, Luciano Rossetti, David E Cohen.

Abstract

To elucidate the control of hepatic cholesterol metabolism by leptin, rats were administered IV (intravenous) leptin, ICV (intracerebroventricular) leptin or saline. A single low dose of ICV leptin was as effective as a continuous IV infusion of high-dose leptin at decreasing the activities of 3-hydroxy-3-methylglutaryl-CoA reductase and cholesterol 7alpha-hydroxylase. These results indicate that the hepatic response to leptin is transduced via the central nervous system.

Entities: Chemical Gene Species

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Year: 2004 PMID： 14984364 PMCID： PMC1224095 DOI： 10.1042/BJ20040134

Source DB: PubMed Journal: Biochem J ISSN： 0264-6021 Impact factor: 3.857

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