Literature DB >> 1059082

Aspartic acid racemization in tooth enamel from living humans.

P M Helfman, J L Bada.   

Abstract

The aspartic acid in human tooth enamel shows increasing racemization with age. This increase is not seen in the metabolically active protein hemoglobin. The rate constant for the racemization reaction of aspartic acid in human tooth enamel was found to be 8.29 X 10(-4) yr-1. This rate constant suggests that in any protein with a long in vivo lifetime, D-aspartic acid will accumulate with age (about 8% of total aspartic acid in enamel will be the D-enantiomer after 60 years). Thus, racemization may play some role in the aging process affecting metabolically stable tissues in long-lived homeotherms. Aspartic acid racemization in toogh enamel also provides a biochronological tool for assessing the age of living mammals.

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Year:  1975        PMID： 1059082      PMCID： PMC432884          DOI： 10.1073/pnas.72.8.2891

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  17 in total

1.  Metabolically inert proteins of the central and peripheral nervous system, muscle and tendon.

Authors:  A N DAVISON
Journal:  Biochem J       Date:  1961-02       Impact factor: 3.857

2.  Studies of the composition of teeth. III. The amino acid composition of human dentinal protein.

Authors:  G C BATTISTONE; G W BURNETT
Journal:  J Dent Res       Date:  1956-04       Impact factor: 6.116

3.  Studies of metabolic turnover with tritium as a tracer. V. The predominantly non-dynamic state of body constituents in the rat.

Authors:  J E BALLOU; R C THOMPSON
Journal:  J Biol Chem       Date:  1956-12       Impact factor: 5.157

4.  On the origin of bile pigment in normal man.

Authors:  I M LONDON; R WEST; D SHEMIN; D RITTENBERG
Journal:  J Biol Chem       Date:  1950-05       Impact factor: 5.157

5.  Caucasus and Altay longevity: a biological or social problem?

Authors:  Z A Medvedev
Journal:  Gerontologist       Date:  1974-10

6.  Kinetics of racemization of amino acids as a function of pH.

Authors:  J L Bada
Journal:  J Am Chem Soc       Date:  1972-02-23       Impact factor: 15.419

7.  Determination of D- and L-amino acids by ion exchange chromatography as L-D and L-L dipeptides.

Authors:  J M Manning; S Moore
Journal:  J Biol Chem       Date:  1968-11-10       Impact factor: 5.157

8.  Marine sediments: dating by the racemization of amino acids.

Authors:  J L Bada; B P Luyendyk; J B Maynard
Journal:  Science       Date:  1970-11-13       Impact factor: 47.728

9.  Concordance of collagen-based radiocarbon and aspartic-acid racemization ages.

Authors:  J L Bada; R A Schroeder; R Protsch; R Berger
Journal:  Proc Natl Acad Sci U S A       Date:  1974-03       Impact factor: 11.205

10.  Racemization of amino acids in marine sediments.

Authors:  J Wehmiller; P E Hare
Journal:  Science       Date:  1971-09-03       Impact factor: 47.728
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  46 in total

1.  Differences in the D/L aspartic acid ratios in dentin among different types of teeth from the same individual and estimated age.

Authors:  S Ohtani; R Ito; T Yamamoto
Journal:  Int J Legal Med       Date:  2003-03-21       Impact factor: 2.686

2.  Age estimation based on aspartic acid racemization in human sclera.

Authors:  Karolin Klumb; Christian Matzenauer; Alexandra Reckert; Klaus Lehmann; Stefanie Ritz-Timme
Journal:  Int J Legal Med       Date:  2015-08-25       Impact factor: 2.686

3.  Age-dependent deamidation of glutamine residues in human γS crystallin: deamidation and unstructured regions.

Authors:  Michelle Yu Sung Hooi; Mark J Raftery; Roger John Willis Truscott
Journal:  Protein Sci       Date:  2012-06-11       Impact factor: 6.725

4.  Racemization in enamel among different types of teeth from the same individual.

Authors:  Susumu Ohtani; Rei Ito; Szilvia Arany; Toshiharu Yamamoto
Journal:  Int J Legal Med       Date:  2005-01-12       Impact factor: 2.686

5.  Amino Acid recycling in relation to protein turnover.

Authors:  D D Davies; T J Humphrey
Journal:  Plant Physiol       Date:  1978-01       Impact factor: 8.340

6.  Racemization of two proteins over our lifespan: deamidation of asparagine 76 in γS crystallin is greater in cataract than in normal lenses across the age range.

Authors:  Michelle Yu Sung Hooi; Mark J Raftery; Roger John Willis Truscott
Journal:  Invest Ophthalmol Vis Sci       Date:  2012-06-14       Impact factor: 4.799

Review 7.  Protein homeostasis: live long, won't prosper.

Authors:  Brandon H Toyama; Martin W Hetzer
Journal:  Nat Rev Mol Cell Biol       Date:  2013-01       Impact factor: 94.444

8.  Methylation at D-aspartyl residues in erythrocytes: possible step in the repair of aged membrane proteins.

Authors:  P N McFadden; S Clarke
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

9.  Age estimation in forensic sciences: application of combined aspartic acid racemization and radiocarbon analysis.

Authors:  Kanar Alkass; Bruce A Buchholz; Susumu Ohtani; Toshiharu Yamamoto; Henrik Druid; Kirsty L Spalding
Journal:  Mol Cell Proteomics       Date:  2009-12-04       Impact factor: 5.911

10.  Racemized and Isomerized Proteins in Aging Rat Teeth and Eye Lens.

Authors:  Rebeccah A Warmack; Eduardo Mansilla; Rodolfo G Goya; Steven G Clarke
Journal:  Rejuvenation Res       Date:  2016-02-26       Impact factor: 4.663
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