OBJECTIVE: This study investigated prefrontal cortex function in the manic state of bipolar disorder. METHOD: High-sensitivity [15O]H2O positron emission tomography and a word generation activation paradigm were used to study regional cerebral blood flow in five manic and six euthymic individuals with bipolar disorder and in five healthy individuals. RESULTS: Decreased right rostral and orbital prefrontal cortex activation during word generation and decreased orbitofrontal activity during rest were associated with mania. CONCLUSIONS: The data support the presence of rostral and orbital prefrontal dysfunction in primary mania. These findings, when seen in the context of the human brain lesion and the behavioral neuroanatomic literatures, may help to explain some of the neurobehavioral abnormalities characteristic of the manic state.
OBJECTIVE: This study investigated prefrontal cortex function in the manic state of bipolar disorder. METHOD: High-sensitivity [15O]H2O positron emission tomography and a word generation activation paradigm were used to study regional cerebral blood flow in five manic and six euthymic individuals with bipolar disorder and in five healthy individuals. RESULTS: Decreased right rostral and orbital prefrontal cortex activation during word generation and decreased orbitofrontal activity during rest were associated with mania. CONCLUSIONS: The data support the presence of rostral and orbital prefrontal dysfunction in primary mania. These findings, when seen in the context of the humanbrain lesion and the behavioral neuroanatomic literatures, may help to explain some of the neurobehavioral abnormalities characteristic of the manic state.
Authors: Harry B M Uylings; Ernesto J Sanz-Arigita; Koos de Vos; Chris W Pool; Paul Evers; Grazyna Rajkowska Journal: Psychiatry Res Date: 2010-06-09 Impact factor: 3.222
Authors: M T Keener; J C Fournier; B C Mullin; D Kronhaus; S B Perlman; E LaBarbara; J C Almeida; M L Phillips Journal: Psychol Med Date: 2012-01-25 Impact factor: 7.723
Authors: Hilary P Blumberg; Nelson H Donegan; Charles A Sanislow; Susan Collins; Cheryl Lacadie; Pawel Skudlarski; Ralitza Gueorguieva; Robert K Fulbright; Thomas H McGlashan; John C Gore; John H Krystal Journal: Psychopharmacology (Berl) Date: 2005-10-26 Impact factor: 4.530
Authors: Gonçalo Cotovio; Daniel Talmasov; J Bernardo Barahona-Corrêa; Joey Hsu; Suhan Senova; Ricardo Ribeiro; Louis Soussand; Ana Velosa; Vera Cruz E Silva; Natalia Rost; Ona Wu; Alexander L Cohen; Albino J Oliveira-Maia; Michael D Fox Journal: J Clin Invest Date: 2020-10-01 Impact factor: 14.808