Literature DB >> 10581236

Mre11 is essential for the maintenance of chromosomal DNA in vertebrate cells.

Y Yamaguchi-Iwai1, E Sonoda, M S Sasaki, C Morrison, T Haraguchi, Y Hiraoka, Y M Yamashita, T Yagi, M Takata, C Price, N Kakazu, S Takeda.   

Abstract

Yeast Mre11 functions with Rad50 and Xrs2 in a complex that has pivotal roles in homologous recombination (HR) and non-homologous end-joining (NHEJ) DNA double-strand break (DSB) repair pathways. Vertebrate Mre11 is essential. Conditionally, MRE11 null chicken DT40 cells accumulate chromosome breaks and die upon Mre11 repression, showing frequent centrosome amplification. Mre11 deficiency also causes increased radiosensitivity and strongly reduced targeted integration frequencies. Mre11 is, therefore, crucial for HR and essential in mitosis through its role in chromosome maintenance by recombinational repair. Surprisingly perhaps, given the role of Mre11 in yeast NHEJ, disruption of NHEJ by deletion of KU70 greatly exacerbates the effects of MRE11 deficiency, revealing a significant Mre11-independent component of metazoan NHEJ.

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Year:  1999        PMID： 10581236      PMCID： PMC1171725          DOI： 10.1093/emboj/18.23.6619

Source DB:  PubMed          Journal:  EMBO J        ISSN： 0261-4189            Impact factor:   11.598


  99 in total

1.  A functional interaction of Ku with Werner exonuclease facilitates digestion of damaged DNA.

Authors:  D K Orren; A Machwe; P Karmakar; J Piotrowski; M P Cooper; V A Bohr
Journal:  Nucleic Acids Res       Date:  2001-05-01       Impact factor: 16.971

2.  Ku recruits the XRCC4-ligase IV complex to DNA ends.

Authors:  S A Nick McElhinny; C M Snowden; J McCarville; D A Ramsden
Journal:  Mol Cell Biol       Date:  2000-05       Impact factor: 4.272

Review 3.  Reverse genetic studies of homologous DNA recombination using the chicken B-lymphocyte line, DT40.

Authors:  E Sonoda; C Morrison; Y M Yamashita; M Takata; S Takeda
Journal:  Philos Trans R Soc Lond B Biol Sci       Date:  2001-01-29       Impact factor: 6.237

4.  Reconstitution of the mammalian DNA double-strand break end-joining reaction reveals a requirement for an Mre11/Rad50/NBS1-containing fraction.

Authors:  Juren Huang; William S Dynan
Journal:  Nucleic Acids Res       Date:  2002-02-01       Impact factor: 16.971

Review 5.  Homologous DNA recombination in vertebrate cells.

Authors:  E Sonoda; M Takata; Y M Yamashita; C Morrison; S Takeda
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

Review 6.  Rescue of arrested replication forks by homologous recombination.

Authors:  B Michel; M J Flores; E Viguera; G Grompone; M Seigneur; V Bidnenko
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

Review 7.  Manipulating the mammalian genome by homologous recombination.

Authors:  K M Vasquez; K Marburger; Z Intody; J H Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  2001-07-17       Impact factor: 11.205

8.  Brca2 (XRCC11) deficiency results in radioresistant DNA synthesis and a higher frequency of spontaneous deletions.

Authors:  Maria Kraakman-van der Zwet; Wilhelmina J I Overkamp; Rebecca E E van Lange; Jeroen Essers; Annemarie van Duijn-Goedhart; Ingrid Wiggers; Srividya Swaminathan; Paul P W van Buul; Abdellatif Errami; Raoul T L Tan; Nicolaas G J Jaspers; Shyam K Sharan; Roland Kanaar; Malgorzata Z Zdzienicka
Journal:  Mol Cell Biol       Date:  2002-01       Impact factor: 4.272

9.  Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis.

Authors:  R S Maser; O K Mirzoeva; J Wells; H Olivares; B R Williams; R A Zinkel; P J Farnham; J H Petrini
Journal:  Mol Cell Biol       Date:  2001-09       Impact factor: 4.272

10.  Direct DNA binding by Brca1.

Authors:  T T Paull; D Cortez; B Bowers; S J Elledge; M Gellert
Journal:  Proc Natl Acad Sci U S A       Date:  2001-05-15       Impact factor: 11.205
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