Literature DB >> 11486038

Mre11 complex and DNA replication: linkage to E2F and sites of DNA synthesis.

R S Maser1, O K Mirzoeva, J Wells, H Olivares, B R Williams, R A Zinkel, P J Farnham, J H Petrini.   

Abstract

We show that the Mre11 complex associates with E2F family members via the Nbs1 N terminus. This association and Nbs1 phosphorylation are correlated with S-phase checkpoint proficiency, whereas neither is sufficient individually for checkpoint activation. The Nbs1 E2F interaction occurred near the Epstein-Barr virus origin of replication as well as near a chromosomal replication origin in the c-myc promoter region and was restricted to S-phase cells. The Mre11 complex colocalized with PCNA at replication forks throughout S phase, both prior to and coincident with the appearance of nascent DNA. These data suggest that the Mre11 complex suppresses genomic instability through its influence on both the regulation and progression of DNA replication.

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Year:  2001        PMID： 11486038      PMCID： PMC87318          DOI： 10.1128/MCB.21.17.6006-6016.2001

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  74 in total

Review 1.  The mammalian Mre11-Rad50-nbs1 protein complex: integration of functions in the cellular DNA-damage response.

Authors:  J H Petrini
Journal:  Am J Hum Genet       Date:  1999-05       Impact factor: 11.025

2.  Nbs1 potentiates ATP-driven DNA unwinding and endonuclease cleavage by the Mre11/Rad50 complex.

Authors:  T T Paull; M Gellert
Journal:  Genes Dev       Date:  1999-05-15       Impact factor: 11.361

3.  Conditional gene targeted deletion by Cre recombinase demonstrates the requirement for the double-strand break repair Mre11 protein in murine embryonic stem cells.

Authors:  Y Xiao; D T Weaver
Journal:  Nucleic Acids Res       Date:  1997-08-01       Impact factor: 16.971

4.  Holliday junctions accumulate in replication mutants via a RecA homolog-independent mechanism.

Authors:  H Zou; R Rothstein
Journal:  Cell       Date:  1997-07-11       Impact factor: 41.582

Review 5.  The effects of ionizing radiation on DNA synthesis in eukaryotic cells.

Authors:  R Rowley; E N Phillips; A L Schroeder
Journal:  Int J Radiat Biol       Date:  1999-03       Impact factor: 2.694

6.  The BRCT domain of the S. cerevisiae checkpoint protein Rad9 mediates a Rad9-Rad9 interaction after DNA damage.

Authors:  J Soulier; N F Lowndes
Journal:  Curr Biol       Date:  1999-05-20       Impact factor: 10.834

7.  The Mre11-Rad50-Xrs2 protein complex facilitates homologous recombination-based double-strand break repair in Saccharomyces cerevisiae.

Authors:  D A Bressan; B K Baxter; J H Petrini
Journal:  Mol Cell Biol       Date:  1999-11       Impact factor: 4.272

8.  Disruption of mRad50 causes embryonic stem cell lethality, abnormal embryonic development, and sensitivity to ionizing radiation.

Authors:  G Luo; M S Yao; C F Bender; M Mills; A R Bladl; A Bradley; J H Petrini
Journal:  Proc Natl Acad Sci U S A       Date:  1999-06-22       Impact factor: 11.205

9.  Embryonic lethality and radiation hypersensitivity mediated by Rad51 in mice lacking Brca2.

Authors:  S K Sharan; M Morimatsu; U Albrecht; D S Lim; E Regel; C Dinh; A Sands; G Eichele; P Hasty; A Bradley
Journal:  Nature       Date:  1997-04-24       Impact factor: 49.962

10.  The timing of the formation and usage of replicase clusters in S-phase nuclei of human diploid fibroblasts.

Authors:  I R Kill; J M Bridger; K H Campbell; G Maldonado-Codina; C J Hutchison
Journal:  J Cell Sci       Date:  1991-12       Impact factor: 5.285
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  96 in total

1.  Genomic instability in mice lacking histone H2AX.

Authors:  Arkady Celeste; Simone Petersen; Peter J Romanienko; Oscar Fernandez-Capetillo; Hua Tang Chen; Olga A Sedelnikova; Bernardo Reina-San-Martin; Vincenzo Coppola; Eric Meffre; Michael J Difilippantonio; Christophe Redon; Duane R Pilch; Alexandru Olaru; Michael Eckhaus; R Daniel Camerini-Otero; Lino Tessarollo; Ferenc Livak; Katia Manova; William M Bonner; Michel C Nussenzweig; André Nussenzweig
Journal:  Science       Date:  2002-04-04       Impact factor: 47.728

2.  SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint.

Authors:  Parvin T Yazdi; Yi Wang; Song Zhao; Nimitt Patel; Eva Y-H P Lee; Jun Qin
Journal:  Genes Dev       Date:  2002-03-01       Impact factor: 11.361

3.  Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells.

Authors:  Rachid Drissi; Jing Wu; Yafang Hu; Carol Bockhold; Jeffrey S Dome
Journal:  Cancer Prev Res (Phila)       Date:  2011-09-19

4.  S-phase checkpoint genes safeguard high-fidelity sister chromatid cohesion.

Authors:  Cheryl D Warren; D Mark Eckley; Marina S Lee; Joseph S Hanna; Adam Hughes; Brian Peyser; Chunfa Jie; Rafael Irizarry; Forrest A Spencer
Journal:  Mol Biol Cell       Date:  2004-01-23       Impact factor: 4.138

5.  MlaA, a hexameric ATPase linked to the Mre11 complex in archaeal genomes.

Authors:  Angelo Manzan; Günter Pfeiffer; Melissa L Hefferin; Cara E Lang; James P Carney; Karl-Peter Hopfner
Journal:  EMBO Rep       Date:  2004-01       Impact factor: 8.807

Review 6.  DNA replication: a complex matter.

Authors:  Isabelle Frouin; Alessandra Montecucco; Silvio Spadari; Giovanni Maga
Journal:  EMBO Rep       Date:  2003-07       Impact factor: 8.807

7.  Transcription factor binding and induced transcription alter chromosomal c-myc replicator activity.

Authors:  M Ghosh; G Liu; G Randall; J Bevington; M Leffak
Journal:  Mol Cell Biol       Date:  2004-12       Impact factor: 4.272

8.  Nuclear phosphoinositide 3-kinase beta controls double-strand break DNA repair.

Authors:  Amit Kumar; Oscar Fernandez-Capetillo; Oscar Fernadez-Capetillo; Ana C Carrera
Journal:  Proc Natl Acad Sci U S A       Date:  2010-04-05       Impact factor: 11.205

9.  Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation.

Authors:  Erik S Zimmerman; Junjie Chen; Joshua L Andersen; Orly Ardon; Jason L Dehart; Jana Blackett; Shailesh K Choudhary; David Camerini; Paul Nghiem; Vicente Planelles
Journal:  Mol Cell Biol       Date:  2004-11       Impact factor: 4.272

10.  Activation of DNA damage repair pathways by murine polyomavirus.

Authors:  Katie Heiser; Catherine Nicholas; Robert L Garcea
Journal:  Virology       Date:  2016-08-16       Impact factor: 3.616
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