Literature DB >> 105727

The exocellular DD-carboxypeptidase-endopeptidase of Streptomyces albus G. Interaction with beta-lactam antibiotics.

J M Frère, F Geurts, J M Ghuysen.   

Abstract

Kinetically, the three-step model proposed for the interaction between beta-lactam antibiotics and the exocellular DD-carboxypeptidases-transpeptidases of Streptomyces R61 and Actinomadura R39 [Frère, Ghuysen & Iwatsubo (1975) Eur. J. Biochem. 57, 343--357; Fuad, Frère, Ghuysen, Duez & Iwatsubo (1976) Biochem. J. 155, 623--629] applies to the interaction between the much less penicillin-sensitive exocellular DD-carboxypeptidase-endopeptidase of Streptomyces albus G and at least phenoxymethylpenicillin, cephalothin and cephalosporin C. The penicillin resistance of the albus G enzyme is mainly due to the low efficiency with which the first reversible complex formed with the antibiotic (complex EI) undergoes transformation into a second more stable complex EI*. Analysis of the ternary interaction between enzyme, NalphaNepsilon-diacetyl-L-lysyl-D-alanyl-D-alanine (Ac2-L-Lys-D-Ala-D-Ala) and cephalosporin C indicates a non-competitive mechanism.

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Year:  1978        PMID： 105727      PMCID： PMC1186140          DOI： 10.1042/bj1750801

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  11 in total

1.  Kinetics of interaction between the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R61 and beta-lactam antibiotics. A choice of models.

Authors:  J M Frère; J M Ghuysen; M Iwatsubo
Journal:  Eur J Biochem       Date:  1975-09-15

2.  On the mechanism of action of antibiotics which act as irreversible enzyme inhibitors.

Authors:  R R Rando
Journal:  Biochem Pharmacol       Date:  1975-06-15       Impact factor: 5.858

3.  Fragmentation of benzylpenicillin after interaction with the exocellular DD-carboxypeptidase-transpeptidases of Streptomyces R61 and R39.

Authors:  J Frere; J Ghuysen; J Degelaen; A Loffet; H R Perkins
Journal:  Nature       Date:  1975-11-13       Impact factor: 49.962

4.  Exocellular DD-carboxypeptidases-transpeptidases from Streptomyces.

Authors:  J M Frére; M Leyh-Bouille; J M Ghuysen; M Nieto; H R Perkins
Journal:  Methods Enzymol       Date:  1976       Impact factor: 1.600

5.  On the Streptomyces albus G DD carboxypeptidase mechanism of action of penicillin, vancomycin, and ristocetin.

Authors:  M Leyh-Bouille; J M Ghuysen; M Nieto; H R Perkins; K H Schleifer; O Kandler
Journal:  Biochemistry       Date:  1970-07-21       Impact factor: 3.162

6.  Fate of thiazolidine ring during fragmentation of penicillin by exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R61.

Authors:  J Frere; J Ghuysen; H Vanderhaeghe; P Adriaens; J Degelaen; J De Graeve
Journal:  Nature       Date:  1976-04-01       Impact factor: 49.962

7.  The exocellular DD-carboxypeptidase-endopeptidase from Streptomyces albus G. Purification and chemical properties.

Authors:  C Duez; J M Frère; F Geurts; J M Ghuysen; L Dierickx; L Delcambe
Journal:  Biochem J       Date:  1978-12-01       Impact factor: 3.857

8.  Purification of the membrane-bound DD-carboxypeptidase of the unstable spheroplast L-form of Proteus mirabilis by affinity chromatography. Non-competitive inhibition of the enzyme by penicillins and low stability of the enzyme-inhibitor complex.

Authors:  H H Martin; W Schilf; C Maskos
Journal:  Eur J Biochem       Date:  1976-12-11

9.  Interaction between penicillin and the DD-carboxypeptidase of the unstable L-form of Proteus mirabilis strain 19.

Authors:  W Schilf; P Frère; J M Frère; H H Martin; J M Ghuysen; P Adriaens; B Meesschaert
Journal:  Eur J Biochem       Date:  1978-04-17

10.  Stability of D-5,5-dimethyl-delta2-thiazoline-4-carboxylic acid in relation to its possible occurrence as a degradation product of penicillin by the exocellular DD-carboxypeptidase-transpeptidase from Streptomyces R61 and the membrane-bound dd-carboxypeptidase from Bacillus stearothermophilus.

Authors:  P Adriaens; B Meesschaert; J M Frère; H Vanderhaeghe; J Degelaen; J M Ghuysen; H Eyssen
Journal:  J Biol Chem       Date:  1978-05-25       Impact factor: 5.157
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  5 in total

1.  The exocellular DD-carboxypeptidase-endopeptidase from Streptomyces albus G. Purification and chemical properties.

Authors:  C Duez; J M Frère; F Geurts; J M Ghuysen; L Dierickx; L Delcambe
Journal:  Biochem J       Date:  1978-12-01       Impact factor: 3.857

2.  Interactions between non-classical beta-lactam compounds and the beta-lactamases of Actinomadura R39 and Streptomyces albus G.

Authors:  J A Kelly; J M Frère; C Duez; J M Ghuysen
Journal:  Biochem J       Date:  1981-10-01       Impact factor: 3.857

3.  The exocellular beta-lactamase of Streptomyces albus G. Purification, properties and comparison with the exocellular DD-carboxypeptidase.

Authors:  C Duez; J M Frère; D Klein; M Noël; J M Ghuysen; L Delcambe; L Dierickx
Journal:  Biochem J       Date:  1981-01-01       Impact factor: 3.857

4.  Active-site-directed inactivators of the Zn2+-containing D-alanyl-D-alanine-cleaving carboxypeptidase of Streptomyces albus G.

Authors:  P Charlier; O Dideberg; J C Jamoulle; J M Frère; J M Ghuysen; G Dive; J Lamotte-Brasseur
Journal:  Biochem J       Date:  1984-05-01       Impact factor: 3.857

5.  Interaction between non-classical beta-lactam compounds and the Zn2+-containing G and serine R61 and R39 D-alanyl-D-alanine peptidases.

Authors:  J A Kelly; J M Frère; D Klein; J M Ghuysen
Journal:  Biochem J       Date:  1981-10-01       Impact factor: 3.857
  5 in total

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