Literature DB >> 10559294

Oncogenic role of Epstein-Barr virus-encoded RNAs in Burkitt's lymphoma cell line Akata.

J Komano1, S Maruo, K Kurozumi, T Oda, K Takada.   

Abstract

Our previous reports indicated that Epstein-Barr virus (EBV) contributes to the malignant phenotype and resistance to apoptosis in Burkitt's lymphoma (BL) cell line Akata (N. Shimizu, A. Tanabe-Tochikura, Y. Kuroiwa, and K. Takada, J. Virol. 68:6069-6073, 1994; J. Komano, M. Sugiura, and K. Takada, J. Virol. 72:9150-9156, 1998). Here we report that the EBV-encoded small RNAs (EBERs) are responsible for these phenotypes. Transfection of the EBER genes into EBV-negative Akata clones restored the capacity for growth in soft agar, tumorigenicity in SCID mice, resistance to apoptotic inducers, and upregulated expression of bcl-2 oncoprotein that were originally retained in parental EBV-positive Akata cells and lost in EBV-negative subclones. This is the first report which provides evidence that virus-encoded RNAs (EBERs) have oncogenic functions in BL cells.

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Year:  1999        PMID： 10559294      PMCID： PMC113031     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  32 in total

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Journal:  Mol Cell Biol       Date:  1991-01       Impact factor: 4.272

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Journal:  Science       Date:  1983-11-18       Impact factor: 47.728

5.  Epstein-barr virus regulates c-MYC, apoptosis, and tumorigenicity in Burkitt lymphoma.

Authors:  I K Ruf; P W Rhyne; H Yang; C M Borza; L M Hutt-Fletcher; J L Cleveland; J T Sample
Journal:  Mol Cell Biol       Date:  1999-03       Impact factor: 4.272

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Journal:  Nature       Date:  1988-09-29       Impact factor: 49.962

Review 7.  Translocations t(14;18) and t(8;14) with rearranged bcl-2 and c-myc in a case presenting as B-ALL (L3).

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Journal:  Leukemia       Date:  1991-01       Impact factor: 11.528

8.  Two small RNAs encoded by Epstein-Barr virus and complexed with protein are precipitated by antibodies from patients with systemic lupus erythematosus.

Authors:  M R Lerner; N C Andrews; G Miller; J A Steitz
Journal:  Proc Natl Acad Sci U S A       Date:  1981-02       Impact factor: 11.205

9.  Differences in B cell growth phenotype reflect novel patterns of Epstein-Barr virus latent gene expression in Burkitt's lymphoma cells.

Authors:  M Rowe; D T Rowe; C D Gregory; L S Young; P J Farrell; H Rupani; A B Rickinson
Journal:  EMBO J       Date:  1987-09       Impact factor: 11.598

10.  EAP, a highly conserved cellular protein associated with Epstein-Barr virus small RNAs (EBERs).

Authors:  D P Toczyski; J A Steitz
Journal:  EMBO J       Date:  1991-02       Impact factor: 11.598
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  80 in total

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Authors:  J Komano; K Takada
Journal:  J Virol       Date:  2001-02       Impact factor: 5.103

2.  Themed issue: the biology and pathology of the Epstein-Barr virus.

Authors:  P G Murray; L S Young
Journal:  Mol Pathol       Date:  2000-10

3.  Latent membrane protein 2A-mediated effects on the phosphatidylinositol 3-Kinase/Akt pathway.

Authors:  R Swart; I K Ruf; J Sample; R Longnecker
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4.  Variant chromatin structure of the oriP region of Epstein-Barr virus and regulation of EBER1 expression by upstream sequences and oriP.

Authors:  B Wensing; A Stühler; P Jenkins; M Hollyoake; C E Karstegl; P J Farrell
Journal:  J Virol       Date:  2001-07       Impact factor: 5.103

5.  Epstein-Barr virus small RNAs potentiate tumorigenicity of Burkitt lymphoma cells independently of an effect on apoptosis.

Authors:  I K Ruf; P W Rhyne; C Yang; J L Cleveland; J T Sample
Journal:  J Virol       Date:  2000-11       Impact factor: 5.103

Review 6.  Noncoding RNPs of viral origin.

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Journal:  Cold Spring Harb Perspect Biol       Date:  2011-03-01       Impact factor: 10.005

Review 7.  Epstein-Barr Virus-associated lymphoproliferative disorders: experimental and clinical developments.

Authors:  Lingyun Geng; Xin Wang
Journal:  Int J Clin Exp Med       Date:  2015-09-15

8.  EB virus-encoded RNAs are recognized by RIG-I and activate signaling to induce type I IFN.

Authors:  Mrinal Samanta; Dai Iwakiri; Teru Kanda; Tadaatsu Imaizumi; Kenzo Takada
Journal:  EMBO J       Date:  2006-08-31       Impact factor: 11.598

9.  Critical role of Epstein-Barr Virus (EBV)-encoded RNA in efficient EBV-induced B-lymphocyte growth transformation.

Authors:  Misako Yajima; Teru Kanda; Kenzo Takada
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103

10.  Sequences adjacent to oriP improve the persistence of Epstein-Barr virus-based episomes in B cells.

Authors:  R E White; R Wade-Martins; M R James
Journal:  J Virol       Date:  2001-11       Impact factor: 5.103
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