Literature DB >> 1055418

Immunological relationship between acetylcholine receptor and thymus: a possible significance in myasthenia gravis.

A Aharonov, R Tarrab-Hazdai, O Abramsky, S Fuchs.   

Abstract

A defined immunological cross-reaction was observed between acetylcholine receptor fraction from the electric eel, Electrophorus electricus, and two calf thymus fractions. The cross-reaction was demonstrated on the cellular level by means of the lymphocyte transformation technique, and on the humoral level, by means of the microcomplement fixation assay. In the human disease myasthenia gravis both acetylcholine receptor at the neuromuscular junction and the thymus are affected, probably by an autoimmune mechanism. The immunological cross-reaction between acetylcholine receptor and thymic components may explain the association between endplate and thymus disorders in myasthenia gravis.

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Year:  1975        PMID： 1055418      PMCID： PMC432554          DOI： 10.1073/pnas.72.4.1456

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  32 in total

1.  Basic encephalitogenic protein: A simplified purification on sulphoethyl-sephadex.

Authors:  H Hirshfeld; D Teitelbaum; R Arnon; M Sela
Journal:  FEBS Lett       Date:  1970-05-01       Impact factor: 4.124

Review 2.  Thymic hormones and the immune response.

Authors:  N Trainin
Journal:  Physiol Rev       Date:  1974-04       Impact factor: 37.312

3.  Experimental myasthenia gravis.

Authors:  G Goldstein; W W Hofmann
Journal:  Res Publ Assoc Res Nerv Ment Dis       Date:  1971

4.  Studies on experimental autoimmune thymitis in guinea-pigs.

Authors:  J R Kalden; W G Williamson; R J Johnston; W J Irvine
Journal:  Clin Exp Immunol       Date:  1969-10       Impact factor: 4.330

5.  Neuromuscular junction in myasthenia gravis: decreased acetylcholine receptors.

Authors:  D M Fambrough; D B Drachman; S Satyamurti
Journal:  Science       Date:  1973-10-19       Impact factor: 47.728

6.  Antiglobulin consumption test with sera from patients with myasthenia gravis.

Authors:  J A Aarli; O Tönder
Journal:  Clin Exp Immunol       Date:  1970-07       Impact factor: 4.330

7.  Myasthenia gravis. Immunological relationship between striated muscle and thymus.

Authors:  H W van der Geld; A J Strauss
Journal:  Lancet       Date:  1966-01-08       Impact factor: 79.321

8.  Cell proliferation and antibody production in the secondary response in vitro towards a defined hapten.

Authors:  R Tarrab; A Sulica; J Haimovich; M Sela
Journal:  Eur J Immunol       Date:  1971-08       Impact factor: 5.532

Review 9.  Studies in myasthenia gravis: biologic aspects.

Authors:  A H Rule; P Kornfeld
Journal:  Mt Sinai J Med       Date:  1971 Nov-Dec

10.  Studies in myasthenia gravis: effects of thymectomy. Results on 185 patients with nonthymomatous and thymomatous myasthenia gravis, 1941-1969.

Authors:  A E Papatestas; L I Alpert; K E Osserman; R S Osserman; A E Kark
Journal:  Am J Med       Date:  1971-04       Impact factor: 4.965
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  11 in total

Review 1.  Neurochemistry and behavior in man.

Authors:  G S Omenn
Journal:  West J Med       Date:  1976-12

Review 2.  Desensitization of the nicotinic acetylcholine receptor: molecular mechanisms and effect of modulators.

Authors:  E L Ochoa; A Chattopadhyay; M G McNamee
Journal:  Cell Mol Neurobiol       Date:  1989-06       Impact factor: 5.046

3.  Antibodies against low-density lipoprotein receptor-related protein 4 induce myasthenia gravis.

Authors:  Chengyong Shen; Yisheng Lu; Bin Zhang; Dwight Figueiredo; Jonathan Bean; Jiung Jung; Haitao Wu; Arnab Barik; Dong-Min Yin; Wen-Cheng Xiong; Lin Mei
Journal:  J Clin Invest       Date:  2013-11-08       Impact factor: 14.808

4.  Assessment of cellular and humoral immunity of myasthenics.

Authors:  S W Huang; J W Rose; R F Mayer
Journal:  J Neurol Neurosurg Psychiatry       Date:  1977-11       Impact factor: 10.154

5.  Receptor dysfunctions in human disease.

Authors:  L H Block; W Tenschert; R Locher; W Siegenthaler; W Vetter
Journal:  Klin Wochenschr       Date:  1981-04-15

6.  Acetylcholine receptor-specific suppressive T-cell factor from a retrovirally transformed T-cell line.

Authors:  F Sinigaglia; C Gotti; R Castagnoli; F Clementi
Journal:  Proc Natl Acad Sci U S A       Date:  1984-12       Impact factor: 11.205

7.  Acetylcholine receptor in rabbit thymus: antigenic similarity between acetylcholine receptors of muscle and thymus.

Authors:  S Ueno; K Wada; M Takahashi; S Tarui
Journal:  Clin Exp Immunol       Date:  1980-12       Impact factor: 4.330

8.  [Demonstration of acetylcholine receptor antibodies in the serum of myasthenia gravis patients applying affinity chromatographically purified human acetylcholine receptor preparations (author's transl)].

Authors:  I Kalies; J R Kalden; F Heinz; R W Janzen; L Lachenmayer
Journal:  Klin Wochenschr       Date:  1979-09-03

9.  A modified assay for antibody against the nicotinic acetylcholine receptor in myasthenia gravis.

Authors:  D S Dwyer; R J Bradley; S J Oh; G E Kemp
Journal:  Clin Exp Immunol       Date:  1979-09       Impact factor: 4.330

10.  Passive transfer of experimental autoimmune myasthenia by lymph node cells in inbred guinea pigs.

Authors:  R Tarrab-Hazdi; A Aharonov; O Abramsky; I Yaar; S Fuchs
Journal:  J Exp Med       Date:  1975-09-01       Impact factor: 14.307
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