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Literature DB >> 304474

Assessment of cellular and humoral immunity of myasthenics.

Abstract

A close association of autoimmune diseases or autoimmune phenomena in myasthenia gravis is well known. A comprehensive immunological study of 22 patients with myasthenia gravis showed that changes in the immune system mainly involve the thymus-derived lymphocytes (T cells). Anti-thymus antibody was present in 90% of the patients, and it paralleled the frequency of thymic abnormality in myasthenia gravis. It is postulated that in myasthenia gravis the altered T cell functions caused by anti-thymus antibody result in the formation of an array of autoantibodies including the factor which blocks the neuromuscular transmission.

Entities: Disease Species

Mesh：

Substances：

Year: 1977 PMID： 304474 PMCID： PMC492902 DOI： 10.1136/jnnp.40.11.1053

Source DB: PubMed Journal: J Neurol Neurosurg Psychiatry ISSN： 0022-3050 Impact factor: 10.154

39 in total

1. Studies on autoantibodies in myasthenia gravis.

Authors: E H BEUTNER; E WITEBSKY; D RICKEN; R H ADLER
Journal: JAMA Date: 1962-10-06 Impact factor: 56.272

2. Changes in serum complement activity in patients with myasthenia gravis.

Authors: W L NASTUK; O J PLESCIA; K E OSSERMAN
Journal: Proc Soc Exp Biol Med Date: 1960-10

3. Immune imbalance in dysgammaglobulinaemia type IV.

Authors: J R Hobbs
Journal: Lancet Date: 1968-01-20 Impact factor: 79.321

4. Lymphocyte sensitisation in myasthenia gravis: function of the adult thymus gland.

Authors: E J Field; D Bates; D A Shaw; S G Griffin; B K Shenton; K Smith
Journal: Lancet Date: 1973-09-22 Impact factor: 79.321

5. Destruction of cultured thymus cells by autologous lymphocytes from a patient with myasthenia gravis.

Authors: R Mori; S Kawanami
Journal: Lancet Date: 1973-01-27 Impact factor: 79.321

6. Anaphylactoid transfusion reactions associated with anti-IgA.

Authors: G N Vyas; H A Perkins; H H Fudenberg
Journal: Lancet Date: 1968-08-10 Impact factor: 79.321

7. Thymic muscle cells bear acetylcholine receptors: possible relation to myasthenia gravis.

Authors: I Kao; D B Drachman
Journal: Science Date: 1977-01-07 Impact factor: 47.728

8. Intrathymic pathogenesis and dual genetic control of myasthenia gravis.

Authors: H Wekerle; U P Ketelsen
Journal: Lancet Date: 1977-03-26 Impact factor: 79.321

9. Serum immunoglobulin E levels in patients with neoplastic disease.

Authors: T A Waldmann; J M Bull; R M Bruce; S Broder; M C Jost; S T Balestra; M E Suer
Journal: J Immunol Date: 1974-07 Impact factor: 5.422

10. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.

Authors: M Jondal; G Holm; H Wigzell
Journal: J Exp Med Date: 1972-08-01 Impact factor: 14.307

5 in total

Assessment of cellular and humoral immunity of myasthenics.

1. Studies on autoantibodies in myasthenia gravis.

2. Changes in serum complement activity in patients with myasthenia gravis.

3. Immune imbalance in dysgammaglobulinaemia type IV.

4. Lymphocyte sensitisation in myasthenia gravis: function of the adult thymus gland.

5. Destruction of cultured thymus cells by autologous lymphocytes from a patient with myasthenia gravis.

6. Anaphylactoid transfusion reactions associated with anti-IgA.

7. Thymic muscle cells bear acetylcholine receptors: possible relation to myasthenia gravis.

8. Intrathymic pathogenesis and dual genetic control of myasthenia gravis.

9. Serum immunoglobulin E levels in patients with neoplastic disease.

10. Surface markers on human T and B lymphocytes. I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells.

Review 1. Phenotypic and functional analysis of lymphocytes in myasthenia gravis.

2. Clinical and immunological associations in myasthenia gravis. 2. Cell-mediated immunity.

3. Clinical and immunological associations in myasthenia gravis. 1: Autoantibodies.

4. Lymphocyte subpopulations and surface membrane immunoglobulins in myasthenia gravis.

5. Evaluation of T cell subsets in myasthenia gravis using anti-T cell monoclonal antibodies.