Literature DB >> 1054844

X-ray crystallographic visualization of drug-nucleic acid intercalative binding: structure of an ethidium-dinucleoside monophosphate crystalline complex, Ethidium: 5-iodouridylyl (3'-5') adenosine.

C C Tsai, S C Jain, H M Sobell.   

Abstract

We have cocrystallized the drug ethidium bromide with the dinucleoside monophosphate 5-iodouridylyl(3'-5')adenosine and have solved the three-dimensional structure to atomic resolution by x-ray crystallography. This has allowed the direct visualization of intercalative binding by this drug to a fragment of a nucleic acid double helix.

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Year:  1975        PMID： 1054844      PMCID： PMC432367          DOI： 10.1073/pnas.72.2.628

Source DB:  PubMed          Journal:  Proc Natl Acad Sci U S A        ISSN： 0027-8424            Impact factor:   11.205


  23 in total

1.  COMPLEX FORMATION WITH DNA AND INHIBITION OF ESCHERICHIA COLI RNA POLYMERASE BY ETHIDIUM BROMIDE.

Authors:  M J WARING
Journal:  Biochim Biophys Acta       Date:  1964-06-22

Review 2.  MECHANISMS OF ACTION OF PHENANTHRIDINE AND AMINOQUINALDINE TRYPANOCIDES.

Authors:  B A NEWTON
Journal:  Adv Chemother       Date:  1964

3.  The structure of the DNA-acridine complex.

Authors:  L S LERMAN
Journal:  Proc Natl Acad Sci U S A       Date:  1963-01-15       Impact factor: 11.205

4.  Structural considerations in the interaction of DNA and acridines.

Authors:  L S LERMAN
Journal:  J Mol Biol       Date:  1961-02       Impact factor: 5.469

5.  THE EFFECT OF ACRIDINE DYES ON MATING TYPE FACTORS IN ESCHERICHIA COLI.

Authors:  Y Hirota
Journal:  Proc Natl Acad Sci U S A       Date:  1960-01       Impact factor: 11.205

6.  Angular alteration of the DNA helix by E. coli RNA polymerase.

Authors:  J M Saucier; J C Wang
Journal:  Nat New Biol       Date:  1972-10-11

7.  Stereochemistry of actinomycin binding to DNA. II. Detailed molecular model of actinomycin-DNA complex and its implications.

Authors:  H M Sobell; S C Jain
Journal:  J Mol Biol       Date:  1972-07-14       Impact factor: 5.469

8.  Stereochemistry of intercalation: interaction of daunomycin with DNA.

Authors:  W J Pigram; W Fuller; L D Hamilton
Journal:  Nat New Biol       Date:  1972-01-05

9.  Electron microscopic study of the ethidium bromide-DNA complex.

Authors:  D Freifelder
Journal:  J Mol Biol       Date:  1971-09-14       Impact factor: 5.469

10.  The synthesis and enzymatic polymerization of nucleotides containing mercury: potential tools for nucleic acid sequencing and structural analysis.

Authors:  R M Dale; D C Livingston; D C Ward
Journal:  Proc Natl Acad Sci U S A       Date:  1973-08       Impact factor: 11.205
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  34 in total

1.  X-ray fiber diffraction evidence for neighbor exclusion binding of a platinum metallointercalation reagent to DNA.

Authors:  P J Bond; R Langridge; K W Jennette; S J Lippard
Journal:  Proc Natl Acad Sci U S A       Date:  1975-12       Impact factor: 11.205

2.  Organization of DNA in chromatin.

Authors:  H M Sobell; C C Tsai; S G Gilbert; S C Jain; T D Sakore
Journal:  Proc Natl Acad Sci U S A       Date:  1976-09       Impact factor: 11.205

3.  The action of ionizing radiation on DNA in the presence of quinacrine. III. E.S.R. study: spin transfer in gamma-irradiated lyophilized DNA-quinacrine complexes.

Authors:  A Hissung; K F Weibezahn
Journal:  Radiat Environ Biophys       Date:  1976-07-30       Impact factor: 1.925

4.  The interaction of plant alkaloids with DNA. II. Berberinium chloride.

Authors:  M W Davidson; I Lopp; S Alexander; W D Wilson
Journal:  Nucleic Acids Res       Date:  1977-08       Impact factor: 16.971

5.  Interaction of ethidium bromide with DNA: effect of LiCl and ethylene glycol.

Authors:  J S Balcerski; E S Pysh
Journal:  Nucleic Acids Res       Date:  1976-10       Impact factor: 16.971

6.  A reexamination of the problem of resonance energy transfer between DNA intercalated chromophores using bisintercalating compounds.

Authors:  M Le Bret; J B Le Pecq; J Barbet; B P Roques
Journal:  Nucleic Acids Res       Date:  1977       Impact factor: 16.971

7.  A mechanism for the entrapment of DNA at an air-water interface.

Authors:  T H Eickbush; E N Moudrianakis
Journal:  Biophys J       Date:  1977-06       Impact factor: 4.033

8.  Comparative studies on membrane-associated, folded chromosomes from Escherichia coli.

Authors:  P Dworsky
Journal:  J Bacteriol       Date:  1976-04       Impact factor: 3.490

9.  Stereochemical model for proflavin intercalation in A-DNA.

Authors:  C J Alden; S Arnott
Journal:  Nucleic Acids Res       Date:  1977-11       Impact factor: 16.971

10.  Daunomycin inhibits the B leads to Z transition in poly d(G-C).

Authors:  J B Chaires
Journal:  Nucleic Acids Res       Date:  1983-12-10       Impact factor: 16.971
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