Literature DB >> 593890

Stereochemical model for proflavin intercalation in A-DNA.

C J Alden, S Arnott.   

Abstract

Linked-atom molecular modelling was employed to determine the steric and torsional requirements for intercalation of proflavine into a double-stranded region of DNA compatible with adjacent regions of cohelical A-DNA. The optimum intercalation conformation is characterized by the dihedral angles xi and psi becoming trans, with all sugars retaining the characteristics C3'-endo pucker. This extended conformation results in virtually no helical unwinding, suggesting it may be an appropriate model for an intercalative intermediary in mutagenesis by virtue of its similarity to standard helical DNA.

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Year:  1977        PMID： 593890      PMCID： PMC343205          DOI： 10.1093/nar/4.11.3855

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  18 in total

1.  The structure of the DNA-acridine complex.

Authors:  L S LERMAN
Journal:  Proc Natl Acad Sci U S A       Date:  1963-01-15       Impact factor: 11.205

2.  Structural considerations in the interaction of DNA and acridines.

Authors:  L S LERMAN
Journal:  J Mol Biol       Date:  1961-02       Impact factor: 5.469

3.  Induced circular dichroism of acridine orange bound to double-stranded RNA and transfer RNA.

Authors:  M Zama; S Ichimura
Journal:  Biopolymers       Date:  1976-09       Impact factor: 2.505

4.  Stereochemistry of actinomycin binding to DNA. I. Refinement and further structural details of the actinomycin-deoxyguanosine crystalline complex.

Authors:  S C Jain; H M Sobell
Journal:  J Mol Biol       Date:  1972-07-14       Impact factor: 5.469

5.  Studies of the binding of actinomycin and related compounds to DNA.

Authors:  W Müller; D M Crothers
Journal:  J Mol Biol       Date:  1968-07-28       Impact factor: 5.469

6.  Supercoiling of polyoma virus DNA measured by its interaction with ethidium bromide.

Authors:  L V Crawford; M J Waring
Journal:  J Mol Biol       Date:  1967-04-14       Impact factor: 5.469

7.  Drugs which affect the structure and function of DNA.

Authors:  M J Waring
Journal:  Nature       Date:  1968-09-28       Impact factor: 49.962

8.  Interactions of aromatic residues of proteins with nucleic acids. I. Proton magnetic resonance studies of the binding of tryptophan-containing peptides to poly(adenylic acid) and deoxyribonucleic acid.

Authors:  J L Dimicoli; C Hélène
Journal:  Biochemistry       Date:  1974-02-12       Impact factor: 3.162

9.  Visualization of planar drug intercalations in B-DNA.

Authors:  C J Alden; S Arnott
Journal:  Nucleic Acids Res       Date:  1975-10       Impact factor: 16.971

10.  Sequence specificity of mutagen-nucleic acid complexes in solution: intercalation and mutagen-base pair overlap geometries for proflavine binding to dC-dC-dG-dG and dG-dG-dC-dC self-complementary duplexes.

Authors:  D J Patel; L L Canuel
Journal:  Proc Natl Acad Sci U S A       Date:  1977-07       Impact factor: 11.205
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  11 in total

1.  Fluorescein as a topical fluorescent contrast agent for quantitative microendoscopic inspection of colorectal epithelium.

Authors:  Sandra P Prieto; Keith K Lai; Jonathan A Laryea; Jason S Mizell; William C Mustain; Timothy J Muldoon
Journal:  Biomed Opt Express       Date:  2017-03-24       Impact factor: 3.732

2.  Drug-nucleic acid interactions: conformational flexibility at the intercalation site.

Authors:  H M Berman; S Neidle; R K Stodola
Journal:  Proc Natl Acad Sci U S A       Date:  1978-02       Impact factor: 11.205

3.  A molecular model for proflavine-DNA intercalation.

Authors:  S Neidle; L H Pearl; P Herzyk; H M Berman
Journal:  Nucleic Acids Res       Date:  1988-09-26       Impact factor: 16.971

4.  The influence of terminal 3', 5' phosphates on conformations of dApdA.

Authors:  S Broyde; B Hingerty
Journal:  Nucleic Acids Res       Date:  1979       Impact factor: 16.971

5.  Molecular mechanical studies of proflavine and acridine orange intercalation.

Authors:  A Dearing; P Weiner; P A Kollman
Journal:  Nucleic Acids Res       Date:  1981-03-25       Impact factor: 16.971

6.  In vivo white light and contrast-enhanced vital-dye fluorescence imaging of Barrett's-related neoplasia in a single-endoscopic insertion.

Authors:  Yubo Tang; Jennifer Carns; Alexandros D Polydorides; Sharmila Anandasabapathy; Rebecca R Richards-Kortum
Journal:  J Biomed Opt       Date:  2016-08-01       Impact factor: 3.170

7.  Molecular mechanical simulations on double intercalation of 9-amino acridine into d(CGCGCGC) X d(GCGCGCG): analysis of the physical basis for the neighbor-exclusion principle.

Authors:  S N Rao; P A Kollman
Journal:  Proc Natl Acad Sci U S A       Date:  1987-08       Impact factor: 11.205

8.  The structure of drug-deoxydinucleoside phosphate complex; generalized conformational behavior of intercalation complexes with RNA and DNA fragments.

Authors:  H S Shieh; H M Berman; M Dabrow; S Neidle
Journal:  Nucleic Acids Res       Date:  1980-01-11       Impact factor: 16.971

9.  Sugar pucker geometries at the intercalation site of propidium diiodide into miniature RNA and DNA duplexes in solution.

Authors:  D J Patel; C Shen
Journal:  Proc Natl Acad Sci U S A       Date:  1978-06       Impact factor: 11.205

10.  Nucleic acid binding drugs. Part XIII. Molecular motion in a drug-nucleic acid model system: thermal motion analysis of a proflavine-dinucleoside crystal structure.

Authors:  A K Aggarwal; S Neidle
Journal:  Nucleic Acids Res       Date:  1985-08-12       Impact factor: 16.971
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