Literature DB >> 10508345

Interaction of Qinghaosu (Artemisinin) with Cysteine Sulfhydryl Mediated by Traces of Non-Heme Iron.

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Abstract

The antimalarial action of 1,2,4-trioxanes such as qinghaosu (QHS) may take place through the mechanism shown schematically: In the presence of cysteine traces of non-heme iron (FeSO(4)) may cleave the peroxy bond of QHS rapidly, and the transient carbon-centered radical can attack the sulfur ligand to form a covalent bond.

Entities:  

Year:  1999        PMID： 10508345     DOI： 10.1002/(sici)1521-3773(19990903)38:17<2580::aid-anie2580>3.0.co;2-j

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  7 in total

1.  Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.

Authors:  Hanafy M Ismail; Victoria Barton; Matthew Phanchana; Sitthivut Charoensutthivarakul; Michael H L Wong; Janet Hemingway; Giancarlo A Biagini; Paul M O'Neill; Stephen A Ward
Journal:  Proc Natl Acad Sci U S A       Date:  2016-02-08       Impact factor: 11.205

Review 2.  Qinghaosu (artemisinin): chemistry and pharmacology.

Authors:  Ying Li
Journal:  Acta Pharmacol Sin       Date:  2012-08-27       Impact factor: 6.150

3.  Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells.

Authors:  Kodihalli C Ravindra; Wanxing Eugene Ho; Chang Cheng; Luiz C Godoy; John S Wishnok; Choon Nam Ong; W S Fred Wong; Gerald N Wogan; Steven R Tannenbaum
Journal:  Chem Res Toxicol       Date:  2015-09-21       Impact factor: 3.739

4.  Schistosoma japonicum: In vitro effects of artemether combined with haemin depend on cultivation media and appraisal of artemether products appearing in the media.

Authors:  Shu-Hua Xiao; Yu-Lin Wu; Marcel Tanner; Wen-Min Wu; Jürg Utzinger; Jin-Yan Mei; Bernard Scorneaux; Jacques Chollet; Zili Zhai
Journal:  Parasitol Res       Date:  2003-01-10       Impact factor: 2.289

5.  Alkylating ability of artemisinin after Cu(I)-induced activation.

Authors:  Fatima Bousejra-El Garah; Marguerite Pitié; Laure Vendier; Bernard Meunier; Anne Robert
Journal:  J Biol Inorg Chem       Date:  2009-02-07       Impact factor: 3.358

6.  Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

Authors:  Douglas B Kell
Journal:  BMC Med Genomics       Date:  2009-01-08       Impact factor: 3.063

7.  FINO2 initiates ferroptosis through GPX4 inactivation and iron oxidation.

Authors:  Michael M Gaschler; Alexander A Andia; Hengrui Liu; Joleen M Csuka; Brisa Hurlocker; Christopher A Vaiana; Daniel W Heindel; Dylan S Zuckerman; Pieter H Bos; Eduard Reznik; Ling F Ye; Yulia Y Tyurina; Annie J Lin; Mikhail S Shchepinov; Amy Y Chan; Eveliz Peguero-Pereira; Maksim A Fomich; Jacob D Daniels; Andrei V Bekish; Vadim V Shmanai; Valerian E Kagan; Lara K Mahal; K A Woerpel; Brent R Stockwell
Journal:  Nat Chem Biol       Date:  2018-04-02       Impact factor: 15.040
  7 in total

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