Literature DB >> 10478457

Natural antioxidant, chlorogenic acid, protects against DNA breakage caused by monochloramine.

H Shibata1, Y Sakamoto, M Oka, Y Kono.   

Abstract

Chlorogenic acid prevented a stepwise conversion of plasmid pUC18 DNA, from I-->form II-->form III, induced by 3 mM monochloramine with a half inhibition of 67.4 microM. Chlorogenic acid reacted with monochloramine in a time-dependent manner, and the reaction rate increased with decreasing pH. These results suggest that chlorogenic acid prevents genotoxicity of monochloramine in gastric mucosa.

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Year:  1999        PMID： 10478457     DOI： 10.1271/bbb.63.1295

Source DB:  PubMed          Journal:  Biosci Biotechnol Biochem        ISSN： 0916-8451            Impact factor:   2.043


  16 in total

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Journal:  Pharmacognosy Res       Date:  2014-01
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