Literature DB >> 104708

Dietary rescue of a lethal "null" activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster.

M B Hughes, J C Lucchesi.   

Abstract

The genetic rescue of Pgdn lethal alleles, accomplished by combining them with mutations lacking glucose-6-phosphate dehydrogenase activity, has led to the hypothesis that Pgdn lethality may be due to the accumulation of 6-phosphogluconate. In this article we report the rescue of Pgdn/Y males by dietary supplements (fructose and linolenate) designed to minimize 6-phosphogluconate production.

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Year:  1978        PMID： 104708     DOI： 10.1007/bf00484212

Source DB:  PubMed          Journal:  Biochem Genet        ISSN： 0006-2928            Impact factor:   1.890


  7 in total

1.  The utilization of sugars and other substances by Drosophila.

Authors:  C C HASSETT
Journal:  Biol Bull       Date:  1948-08       Impact factor: 1.818

2.  Regulation of the oxidative NADP-enzyme tissue levels in Drosophila melanogaster. I. Modulation by dietary carbohydrate and lipid.

Authors:  B W Geer; S N Kamiak; K R Kidd; R A Nishimura; S J Yemm
Journal:  J Exp Zool       Date:  1976-01

3.  Role of the pentose phosphate pathway in metabolism of Drosophila melanogaster elucidated by mutations affecting glucose 6-phosphate and 6-phosphogluconate dehydrogenases.

Authors:  V A Gvozdev; T I Gerasimova; G L Kogan
Journal:  FEBS Lett       Date:  1976-04-15       Impact factor: 4.124

4.  The pentose shunt in wild-type and glucose-6-phosphate dehydrogenase deficient Drosophila melanogaster.

Authors:  B W Geer; J T Bowman; J R Simmons
Journal:  J Exp Zool       Date:  1974-01

5.  Fine genetic structure of the 2D3-2F5 region of the X-chromosome of Drosophila melanogaster.

Authors:  V A Gvozdev; S A Gostimsky; T I Gerasimova; E S Dubrovskaya; O Y Braslavskaya
Journal:  Mol Gen Genet       Date:  1975-12-01

6.  Lethal effects of low and "null" activity alleles of 6-phosphogluconate dehydrogenase in Drosophila melanogaster.

Authors:  G C Bewley; J G Lucchesi
Journal:  Genetics       Date:  1975-03       Impact factor: 4.562

7.  Genetic rescue of a lethal "null" activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster.

Authors:  M B Hughes; J C Lucchesi
Journal:  Science       Date:  1977-06-03       Impact factor: 47.728
  7 in total
  9 in total

1.  A hierarchical Bayesian model for a novel sparse partial diallel crossing design.

Authors:  Anthony J Greenberg; Sean R Hackett; Lawrence G Harshman; Andrew G Clark
Journal:  Genetics       Date:  2010-02-15       Impact factor: 4.562

2.  A genetic and molecular analysis of P-induced mutations at the glucose-6-phosphate dehydrogenase locus in Drosophila melanogaster.

Authors:  D Nero; N Bowditch; S Pickert; R J MacIntyre
Journal:  Mol Gen Genet       Date:  1989-11

3.  Genetic and cytogenetic studies of malic enzyme in Drosophila melanogaster.

Authors:  R A Voelker; S Ohnishi; C H Langley; J Gausz; H Gyurkovics
Journal:  Biochem Genet       Date:  1981-06       Impact factor: 1.890

4.  Relationship of the oxidative pentose shunt pathway to lipid synthesis in Drosophila melanogaster.

Authors:  B W Geer; D L Lindel; D M Lindel
Journal:  Biochem Genet       Date:  1979-10       Impact factor: 1.890

5.  Enzyme patterns in D. melanogaster imaginal discs: distribution of glucose-6-phosphate and 6-phosphogluconate dehydrogenase.

Authors:  G N Cunningham; N M Smith; M K Makowski; D T Kuhn
Journal:  Mol Gen Genet       Date:  1983

6.  Regulation of enzyme activities in Drosophila: genetic variation affecting induction of glucose 6-phosphate and 6-phosphogluconate dehydrogenase in larvae.

Authors:  B J Cochrane; J C Lucchesi; C C Laurie-Ahlberg
Journal:  Genetics       Date:  1983-11       Impact factor: 4.562

7.  Polymorphism at the G6pd and 6Pgd loci in Drosophila melanogaster. IV. Genetic factors modifying enzyme activity.

Authors:  R Bijlsma
Journal:  Biochem Genet       Date:  1980-08       Impact factor: 1.890

8.  Genetics of male-specific glucose oxidase and the identification of other unusual hexose enzymes in Drosophila melanogaster.

Authors:  D R Cavener
Journal:  Biochem Genet       Date:  1980-10       Impact factor: 1.890

9.  The effect of DDT on the polymorphism at the G6pd and Pgd loci in Drosophila melanogaster.

Authors:  R Bijlsma; J W Kerver
Journal:  Genetics       Date:  1983-03       Impact factor: 4.562
  9 in total

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