Literature DB >> 813108

Fine genetic structure of the 2D3-2F5 region of the X-chromosome of Drosophila melanogaster.

V A Gvozdev, S A Gostimsky, T I Gerasimova, E S Dubrovskaya, O Y Braslavskaya.   

Abstract

97 lethal and semilethal mutations were induced by ethyl methanesulfonate, nitrosomethyl urea and gamma-irradiation in the 2D3-F5 region of the X-chromosome of D. melanogaster. Approximately 1 per cent of the tested X-chromosomes carried a lethal in the 2D3-2F5 region. The mutation frequencies per band or DNA content in the region and the whole X-chromosome are equal. Complementation analysis revealed at least 10 functionally independent essential loci in this region including about 10 bands. The data presented in this study support the one band--one gene hypothesis. The Pgd locus coding for 6-phosphogluconate dehydrogenase (6PGD) is mapped in the 2D3 (OR 2D4) band. Isolation of 11 lethal or semilethal point mutations with null or reduced 6PGD activity shows that the Pgd locus is a vital one.

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Year:  1975        PMID： 813108     DOI： 10.1007/BF00341805

Source DB:  PubMed          Journal:  Mol Gen Genet        ISSN： 0026-8925


  15 in total

Review 1.  Organization, transcription, and regulation in the animal genome.

Authors:  E H Davidson; R J Britten
Journal:  Q Rev Biol       Date:  1973-12       Impact factor: 4.875

2.  Cytogenetic and complementation analyses of recessive lethal mutations induced in the X chromosome of Drosophila by three alkylating agents.

Authors:  J K Lim; L A Snyder
Journal:  Genet Res       Date:  1974-08       Impact factor: 1.588

Review 3.  Chromomeres and genes.

Authors:  W Beermann
Journal:  Results Probl Cell Differ       Date:  1972

4.  On the structural organization of operon and the regulation of RNA synthesis in animal cells.

Authors:  G P Georgiev
Journal:  J Theor Biol       Date:  1969-12       Impact factor: 2.691

5.  Dosage compensation of sex-linked genes in Drosophila melanogaster. The activities of glucose-6-phosphate dehydrogenase and 6-phosphogluconate dehydrogenase in flies with normal and disturbed genetic balance.

Authors:  L Z Faizullin; V A Gvozdev
Journal:  Mol Gen Genet       Date:  1973-11-12

6.  Inactivation of 6-phosphogluconate dehydrogenase structural gene of Drosophila melanogaster caused by translocation to heterochromatin.

Authors:  V A Gvozdev; T I Gerasimova; V J Birstein
Journal:  Mol Gen Genet       Date:  1974-05-31

7.  The anatomy and function of a segment of the X chromosome of Drosophila melanogaster.

Authors:  B H Judd; M W Shen; T C Kaufman
Journal:  Genetics       Date:  1972-05       Impact factor: 4.562

8.  General model for the chromosomes of higher organisms.

Authors:  F Crick
Journal:  Nature       Date:  1971-11-05       Impact factor: 49.962

9.  A proposal for the structure of the Drosophila genome.

Authors:  J Bonner; J R Wu
Journal:  Proc Natl Acad Sci U S A       Date:  1973-02       Impact factor: 11.205

10.  Dosage compensation for enzyme activities in Drosophila melanogaster.

Authors:  R L Seecof; W D Kaplan; D G Futch
Journal:  Proc Natl Acad Sci U S A       Date:  1969-02       Impact factor: 11.205
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  12 in total

1.  The size and internal structure of a heterochromatic block determine its ability to induce position effect variegation in Drosophila melanogaster.

Authors:  E V Tolchkov; V I Rasheva; S Bonaccorsi; T Westphal; V A Gvozdev
Journal:  Genetics       Date:  2000-04       Impact factor: 4.562

2.  The genetics of a small autosomal region of Drosophila melanogaster containing the structural gene for alcohol dehydrogenase. II. Lethal mutations in the region.

Authors:  R C Woodruff; M Ashburner
Journal:  Genetics       Date:  1979-05       Impact factor: 4.562

3.  Dietary rescue of a lethal "null" activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster.

Authors:  M B Hughes; J C Lucchesi
Journal:  Biochem Genet       Date:  1978-06       Impact factor: 1.890

4.  A genetic and molecular analysis of P-induced mutations at the glucose-6-phosphate dehydrogenase locus in Drosophila melanogaster.

Authors:  D Nero; N Bowditch; S Pickert; R J MacIntyre
Journal:  Mol Gen Genet       Date:  1989-11

5.  Studies of the genetic organization of the vestigial microregion of Drosophila melanogaster.

Authors:  P F Lasko; M L Pardue
Journal:  Genetics       Date:  1988-10       Impact factor: 4.562

6.  Fine cytogenetical analysis of the band 10A1-2 and the adjoining regions in the Drosophila melanogaster X chromosome. II. Genetical analysis.

Authors:  I F Zhimulev; G V Pokholkova; A V Bgatov; V F Semeshin; E S Belyaeva
Journal:  Chromosoma       Date:  1981       Impact factor: 4.316

7.  The distribution of randomly recovered X-ray-induced sex-linked genetic effects in Drosophila melanogaster.

Authors:  G Lefevre
Journal:  Genetics       Date:  1981 Nov-Dec       Impact factor: 4.562

8.  Ontogeny, cell distribution, and the physiological role of NADP-malic enxyme in Drosophila melanogaster.

Authors:  B W Geer; D Krochko; J H Williamson
Journal:  Biochem Genet       Date:  1979-10       Impact factor: 1.890

9.  Investigations on the organization of genetic loci in Drosophila melanogaster: lethal mutations affecting 6-phosphogluconate dehydrogenase and their suppression.

Authors:  V A Gvozdev; T I Gerasimova; G L Kogan; J M Rosovsky
Journal:  Mol Gen Genet       Date:  1977-06-08

10.  Polyhomeotic: a gene of Drosophila melanogaster required for correct expression of segmental identity.

Authors:  J M Dura; H W Brock; P Santamaria
Journal:  Mol Gen Genet       Date:  1985
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