Literature DB >> 805081

Lethal effects of low and "null" activity alleles of 6-phosphogluconate dehydrogenase in Drosophila melanogaster.

G C Bewley, J G Lucchesi.   

Abstract

EMS-induced "null" and low activity alleles for 6-phosphogluconate dehydrogenase were characterized with respect to enzymatic activity, relative viability, fertility, and the effective lethal phase. It was determined that flies hemizygous and homozygous for the low activity allele, Pgd minus, possessed a depressed development rate, diminished viability, and loss of female female fertility. Heterozygotes for Pgd minus and a deficiency for Pgd+ were lethal. The "null" activity allele demonstrated a lethal phenotype in both the hemizygous and homozygous condition. The effective lethal phase for the "null" allele occurs during late embryonic development (20-22 hr).

Entities:  

Mesh：

Substances：

Year:  1975        PMID： 805081      PMCID： PMC1213284     

Source DB:  PubMed          Journal:  Genetics        ISSN： 0016-6731            Impact factor:   4.562


  9 in total

1.  Protein measurement with the Folin phenol reagent.

Authors:  O H LOWRY; N J ROSEBROUGH; A L FARR; R J RANDALL
Journal:  J Biol Chem       Date:  1951-11       Impact factor: 5.157

2.  On estimating functional gene number in eukaryotes.

Authors:  S J O'Brien
Journal:  Nat New Biol       Date:  1973-03-14

3.  The recovery, penetrance, and pleiotropy of X-linked, cold sensitive mutants in Drosophila.

Authors:  T R Wright
Journal:  Mol Gen Genet       Date:  1973-04-12

4.  Time of expression of genes controlling specific enzymes in Drosophila embryos.

Authors:  D A Wright; C R Shaw
Journal:  Biochem Genet       Date:  1970-06       Impact factor: 1.890

5.  X-linked electrophoretic variation in 6-phosphogluconate dehydrogenase in Drosophila melanogaster.

Authors:  W J Young
Journal:  J Hered       Date:  1966 Mar-Apr       Impact factor: 2.645

6.  Molecular size studies on 6-phosphogluconate dehydrogenase.

Authors:  H H Kazazian
Journal:  Nature       Date:  1966-10-08       Impact factor: 49.962

7.  X-linked 6-phosphogluconate dehydrogenase in drosophila: subunit associations.

Authors:  H H Kazazian; W J Young; B Childs
Journal:  Science       Date:  1965-12-17       Impact factor: 47.728

8.  The -glycerophosphate in Drosophila melanogaster. II. Genetic aspects.

Authors:  S J O'Brien; R J Macintyre
Journal:  Genetics       Date:  1972-05       Impact factor: 4.562

9.  Dosage compensation for enzyme activities in Drosophila melanogaster.

Authors:  R L Seecof; W D Kaplan; D G Futch
Journal:  Proc Natl Acad Sci U S A       Date:  1969-02       Impact factor: 11.205
  9 in total
  16 in total

1.  Dietary rescue of a lethal "null" activity allele of 6-phosphogluconate dehydrogenase in Drosophila melanogaster.

Authors:  M B Hughes; J C Lucchesi
Journal:  Biochem Genet       Date:  1978-06       Impact factor: 1.890

2.  Enzyme null alleles in natural populations of Drosophila melanogaster: Frequencies in a North Carolina population.

Authors:  R A Voelker; C H Langley; A J Brown; S Ohnishi; B Dickson; E Montgomery; S C Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1980-02       Impact factor: 11.205

3.  A genetic and molecular analysis of P-induced mutations at the glucose-6-phosphate dehydrogenase locus in Drosophila melanogaster.

Authors:  D Nero; N Bowditch; S Pickert; R J MacIntyre
Journal:  Mol Gen Genet       Date:  1989-11

4.  IN VIVO Function of Rare G6pd Variants from Natural Populations of DROSOPHILA MELANOGASTER.

Authors:  W F Eanes; J Hey
Journal:  Genetics       Date:  1986-07       Impact factor: 4.562

5.  Genetic control of soluble NAD-dependent sorbitol dehydrogenase in Drosophila melanogaster.

Authors:  W L Bischoff
Journal:  Biochem Genet       Date:  1976-12       Impact factor: 1.890

6.  Developmental rate and viability of rainbow trout with a null allele at a lactate dehydrogenase locus.

Authors:  M M Ferguson; K L Knudsen; R G Danzmann; F W Allendorf
Journal:  Biochem Genet       Date:  1988-02       Impact factor: 1.890

7.  6-phosphogluconate dehydrogenase in the housefly, Musca domestica L.:evidence for inheritable 6PGD polymorphism.

Authors:  G Gasperi; A Malacrida; R Milani
Journal:  Biochem Genet       Date:  1979-10       Impact factor: 1.890

8.  Enzyme patterns in D. melanogaster imaginal discs: distribution of glucose-6-phosphate and 6-phosphogluconate dehydrogenase.

Authors:  G N Cunningham; N M Smith; M K Makowski; D T Kuhn
Journal:  Mol Gen Genet       Date:  1983

9.  Investigations on the organization of genetic loci in Drosophila melanogaster: lethal mutations affecting 6-phosphogluconate dehydrogenase and their suppression.

Authors:  V A Gvozdev; T I Gerasimova; G L Kogan; J M Rosovsky
Journal:  Mol Gen Genet       Date:  1977-06-08

10.  The isolation and characterization of mutant alleles at a new X-linked locus, mex, affecting NADP(+)-dependent enzymes in Drosophila melanogaster.

Authors:  A R Gromnicki; M M Bentley
Journal:  Biochem Genet       Date:  1991-04       Impact factor: 1.890
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.