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Literature DB >> 10429656

Relationship between expression of p21WAF1/CIP1 and radioresistance in human gliomas.

Abstract

The role of p21WAF1/CIP1 (p21) in DNA repair and apoptosis following gamma-irradiation remains controversial. In this study the influence of p21 on the radiosensitivity of human brain tumors was investigated. Resected tumors were stained immunohistochemically for p21. Expression of p21 in astrocytic tumors was high, but it was low in medulloblastomas, germinomas, and primary malignant lymphomas. Glioma and medulloblastoma cell lines were transfected with pcDNA/p21 to cause p21 overexpression, then tumor-cell colony formation and apoptosis were assessed following gamma-irradiation of the transfected and nontransfected cells. Overexpression of p21 enhanced clonogenic survival and suppressed apoptosis after gamma-irradiation in human brain tumor cell lines with or without p53 protein deficiency. Radioresistance was acquired when p21 was overproduced in the glioma cell lines irrespective of p53 status.

Entities: CellLine Chemical Disease Gene Species

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Year: 1999 PMID： 10429656 PMCID： PMC5926117 DOI： 10.1111/j.1349-7006.1999.tb00795.x

Source DB: PubMed Journal: Jpn J Cancer Res ISSN： 0910-5050

44 in total

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Journal: Mol Cell Biol Date: 1996-04 Impact factor: 4.272

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Authors: J Shim; H Lee; J Park; H Kim; E J Choi
Journal: Nature Date: 1996-06-27 Impact factor: 49.962

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Journal: Oncogene Date: 1998-02-12 Impact factor: 9.867

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Journal: Cancer Res Date: 1996-05-15 Impact factor: 12.701

6. The apoptotic and transcriptional transactivation activities of p53 can be dissociated.

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Journal: Biochem Cell Biol Date: 1997 Impact factor: 3.626

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Journal: Nature Date: 1995-05-11 Impact factor: 49.962

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Journal: Cancer Res Date: 1995-10-15 Impact factor: 12.701

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Journal: Oncogene Date: 1998-08-27 Impact factor: 9.867

10. WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.

Authors: W S el-Deiry; J W Harper; P M O'Connor; V E Velculescu; C E Canman; J Jackman; J A Pietenpol; M Burrell; D E Hill; Y Wang
Journal: Cancer Res Date: 1994-03-01 Impact factor: 12.701

10 in total

Review 1. Multiple functions of p21 in cancer radiotherapy.

Authors: Yanbei Kuang; Jian Kang; Hongbin Li; Bingtao Liu; Xueshan Zhao; Linying Li; Xiaodong Jin; Qiang Li
Journal: J Cancer Res Clin Oncol Date: 2021-02-05 Impact factor: 4.553

Review 2. Cip/Kip cell-cycle inhibitors: a neuro-oncological perspective.

Authors: T G Mainprize; M D Taylor; J T Rutka; P B Dirks
Journal: J Neurooncol Date: 2001-02 Impact factor: 4.130

Review 3. Clinical Relevance of Steroid Use in Neuro-Oncology.

Authors: K Ina Ly; Patrick Y Wen
Journal: Curr Neurol Neurosci Rep Date: 2017-01 Impact factor: 5.081

4. Overcoming of radioresistance in human gliomas by p21WAF1/CIP1 antisense oligonucleotide.

Authors: T Kokunai; S Urui; H Tomita; N Tamaki
Journal: J Neurooncol Date: 2001-01 Impact factor: 4.130

5. Impact of postoperative dexamethasone on survival, steroid dependency, and infections in newly diagnosed glioblastoma patients.

Authors: Akshitkumar M Mistry; Sumeeth V Jonathan; Meredith A Monsour; Bret C Mobley; Stephen W Clark; Paul L Moots
Journal: Neurooncol Pract Date: 2021-06-23

6. Corticosteroids compromise survival in glioblastoma.

Authors: Kenneth L Pitter; Ilaria Tamagno; Kristina Alikhanyan; Amira Hosni-Ahmed; Siobhan S Pattwell; Shannon Donnola; Charles Dai; Tatsuya Ozawa; Maria Chang; Timothy A Chan; Kathryn Beal; Andrew J Bishop; Christopher A Barker; Terreia S Jones; Bettina Hentschel; Thierry Gorlia; Uwe Schlegel; Roger Stupp; Michael Weller; Eric C Holland; Dolores Hambardzumyan
Journal: Brain Date: 2016-03-28 Impact factor: 13.501