Literature DB >> 11386407

Overcoming of radioresistance in human gliomas by p21WAF1/CIP1 antisense oligonucleotide.

T Kokunai1, S Urui, H Tomita, N Tamaki.   

Abstract

Malignant gliomas are highly resistant tumors against gamma-irradiation and contained overexpression of p21WAF1/CIP1 (p21). Overexpression of p21 enhanced clonogenic survival and suppressed apoptosis after gamma-irradiation in human brain tumor cell lines with or without p53 protein deficiency. The effect of antisense oligonucleotide to p21 against the gamma-irradiation-induced apoptosis and cytotoxicity in malignant glioma cell lines was examined. Antennapedia homeodomain internalization peptide was used as an insertion vector. The high transfection efficiency of Antennapedia homeodomain internalization peptide joined with antisense oligonucleotide was observed. The pretreatment with antisense oligonucleotide enhanced the gamma-irradiation-induced apoptosis and cytotoxicity in radioresistant glioma cells. p21 may represent an important new target for radiosensitization protocols, possibly involving antisense oligonucleotide directed against p21.

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Year:  2001        PMID： 11386407     DOI： 10.1023/a:1010645205169

Source DB:  PubMed          Journal:  J Neurooncol        ISSN： 0167-594X            Impact factor:   4.130


  32 in total

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Journal:  Mol Cell Biol       Date:  1996-04       Impact factor: 4.272

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Journal:  Int J Cancer       Date:  1998-02-09       Impact factor: 7.396

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Journal:  Oncogene       Date:  1998-02-12       Impact factor: 9.867

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Journal:  J Biol Chem       Date:  1994-04-08       Impact factor: 5.157

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Journal:  Cancer Res       Date:  1995-10-15       Impact factor: 12.701

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Journal:  Cancer Res       Date:  1994-12-15       Impact factor: 12.701

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Journal:  J Cell Biol       Date:  1995-03       Impact factor: 10.539
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  7 in total

Review 1.  Multiple functions of p21 in cancer radiotherapy.

Authors:  Yanbei Kuang; Jian Kang; Hongbin Li; Bingtao Liu; Xueshan Zhao; Linying Li; Xiaodong Jin; Qiang Li
Journal:  J Cancer Res Clin Oncol       Date:  2021-02-05       Impact factor: 4.553

Review 2.  Reversion of the ErbB malignant phenotype and the DNA damage response.

Authors:  E Aaron Runkle; Hongtao Zhang; Zheng Cai; Zhiqiang Zhu; Barry L Karger; Shiaw-Lin Wu; Donald M O'Rourke; Zhaocai Zhou; Qiang Wang; Mark I Greene
Journal:  Exp Mol Pathol       Date:  2012-09-27       Impact factor: 3.362

Review 3.  Apoptosis in gliomas: molecular mechanisms and therapeutic implications.

Authors:  Joachim P Steinbach; Michael Weller
Journal:  J Neurooncol       Date:  2004-11       Impact factor: 4.130

Review 4.  Mechanisms of apoptosis in central nervous system tumors: application to theory.

Authors:  Joachim P Steinbach; Michael Weller
Journal:  Curr Neurol Neurosci Rep       Date:  2002-05       Impact factor: 5.081

5.  Radiation therapy causes loss of dermal lymphatic vessels and interferes with lymphatic function by TGF-beta1-mediated tissue fibrosis.

Authors:  Tomer Avraham; Alan Yan; Jamie C Zampell; Sanjay V Daluvoy; Adriana Haimovitz-Friedman; Andrew P Cordeiro; Babak J Mehrara
Journal:  Am J Physiol Cell Physiol       Date:  2010-06-02       Impact factor: 4.249

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Authors:  Nina-Naomi Kreis; Frank Louwen; Juping Yuan
Journal:  Cancers (Basel)       Date:  2019-08-21       Impact factor: 6.639

7.  RNA sequencing of long-term label-retaining colon cancer stem cells identifies novel regulators of quiescence.

Authors:  Joseph L Regan; Dirk Schumacher; Stephanie Staudte; Andreas Steffen; Ralf Lesche; Joern Toedling; Thibaud Jourdan; Johannes Haybaeck; Dominik Mumberg; David Henderson; Balázs Győrffy; Christian R A Regenbrecht; Ulrich Keilholz; Reinhold Schäfer; Martin Lange
Journal:  iScience       Date:  2021-05-24
  7 in total

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