Literature DB >> 10419844

The development and therapeutic potential of protein kinase inhibitors.

P Cohen1.   

Abstract

A number of small cell-permeant protein kinase inhibitors have been developed that have the potential for treating a variety of diseases. The basis for the specificity of several of these drugs has been elucidated and a number are undergoing human clinical trials.

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Year:  1999        PMID： 10419844     DOI： 10.1016/S1367-5931(99)80067-2

Source DB:  PubMed          Journal:  Curr Opin Chem Biol        ISSN： 1367-5931            Impact factor:   8.822


  34 in total

Review 1.  Signaling cascades regulating NMDA receptor sensitivity to ethanol.

Authors:  Dorit Ron
Journal:  Neuroscientist       Date:  2004-08       Impact factor: 7.519

2.  Biochemical characterization of the tobacco 42-kD protein kinase activated by osmotic stress.

Authors:  Anna Kelner; Izabela Pekala; Szymon Kaczanowski; Grazyna Muszynska; D Grahame Hardie; Grazyna Dobrowolska
Journal:  Plant Physiol       Date:  2004-10-01       Impact factor: 8.340

3.  Novel PKCs activate ERK through PKD1 in MCF-7 cells.

Authors:  Claudia Torricelli; Giuseppe Valacchi; Emanuela Maioli
Journal:  In Vitro Cell Dev Biol Anim       Date:  2010-11-13       Impact factor: 2.416

Review 4.  Chemotherapy and signaling: How can targeted therapies supercharge cytotoxic agents?

Authors:  Tetyana V Bagnyukova; Ilya G Serebriiskii; Yan Zhou; Elizabeth A Hopper-Borge; Erica A Golemis; Igor Astsaturov
Journal:  Cancer Biol Ther       Date:  2010-11-01       Impact factor: 4.742

Review 5.  Solution NMR Spectroscopy for the Study of Enzyme Allostery.

Authors:  George P Lisi; J Patrick Loria
Journal:  Chem Rev       Date:  2016-01-06       Impact factor: 60.622

6.  Mechanisms of gamma-glutamylcysteine ligase regulation.

Authors:  Dikran Toroser; Connie S Yarian; William C Orr; Rajindar S Sohal
Journal:  Biochim Biophys Acta       Date:  2005-11-17

7.  Programming with models: modularity and abstraction provide powerful capabilities for systems biology.

Authors:  Aneil Mallavarapu; Matthew Thomson; Benjamin Ullian; Jeremy Gunawardena
Journal:  J R Soc Interface       Date:  2009-03-06       Impact factor: 4.118

8.  Specificity and mechanism of action of some commonly used protein kinase inhibitors.

Authors:  S P Davies; H Reddy; M Caivano; P Cohen
Journal:  Biochem J       Date:  2000-10-01       Impact factor: 3.857

9.  Structural features underlying selective inhibition of protein kinase CK2 by ATP site-directed tetrabromo-2-benzotriazole.

Authors:  R Battistutta; E De Moliner; S Sarno; G Zanotti; L A Pinna
Journal:  Protein Sci       Date:  2001-11       Impact factor: 6.725

Review 10.  The Role of PI3K/Akt and ERK in Neurodegenerative Disorders.

Authors:  Sachchida Nand Rai; Hagera Dilnashin; Hareram Birla; Saumitra Sen Singh; Walia Zahra; Aaina Singh Rathore; Brijesh Kumar Singh; Surya Pratap Singh
Journal:  Neurotox Res       Date:  2019-02-01       Impact factor: 3.911
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