Literature DB >> 10406653

Synthesis and antibacterial properties of beta-diketone acrylate bioisosteres of pseudomonic acid A.

I Bennett1, N J Broom, R Cassels, J S Elder, N D Masson, P J O'Hanlon.   

Abstract

A series of beta-diketone acrylate bioisosteres 4 of pseudomonic acid A 1 have been synthesized and evaluated for their ability to inhibit bacterial isoleucyl-tRNA synthetase and act as antibacterial agents. A number of analogues have excellent antibacterial activity. Selected examples were shown to afford good blood levels and to be effective in a murine infection model.

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Year:  1999        PMID： 10406653     DOI： 10.1016/s0960-894x(99)00296-6

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  7 in total

Review 1.  Prospects for aminoacyl-tRNA synthetase inhibitors as new antimicrobial agents.

Authors:  Julian Gregston Hurdle; Alexander John O'Neill; Ian Chopra
Journal:  Antimicrob Agents Chemother       Date:  2005-12       Impact factor: 5.191

Review 2.  Resistance to and synthesis of the antibiotic mupirocin.

Authors:  Christopher M Thomas; Joanne Hothersall; Christine L Willis; Thomas J Simpson
Journal:  Nat Rev Microbiol       Date:  2010-03-01       Impact factor: 60.633

3.  Analogs of natural aminoacyl-tRNA synthetase inhibitors clear malaria in vivo.

Authors:  Eva Maria Novoa; Noelia Camacho; Anna Tor; Barrie Wilkinson; Steven Moss; Patricia Marín-García; Isabel G Azcárate; José M Bautista; Adam C Mirando; Christopher S Francklyn; Sònia Varon; Miriam Royo; Alfred Cortés; Lluís Ribas de Pouplana
Journal:  Proc Natl Acad Sci U S A       Date:  2014-12-08       Impact factor: 11.205

4.  [2-(2-Meth-oxy-1-naphtho-yl)phen-yl](1-naphth-yl)methanone.

Authors:  G Jagadeesan; K Sethusankar; R Sivasakthikumaran; Arasambattu K Mohanakrishnan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-10-29

5.  [2-(4-Methylbenzoyl)phenyl](4-methylphenyl)methanone.

Authors:  P Narayanan; K Sethusankar; Meganathan Nandakumar; Arasambattu K Mohanakrishnan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-07-23

6.  (Biphenyl-4-yl)[2-(4-methyl-benzo-yl)phen-yl]methanone.

Authors:  V Silambarasan; T Srinivasan; S Sivasakthikumaran; A K Mohanakrishnan; D Velmurugan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-11-12

7.  (2-Benzoyl-phen-yl)(2-meth-oxy-1-naphth-yl)methanone.

Authors:  G Jagadeesan; K Sethusankar; R Sivasakthikumaran; Arasambattu K Mohanakrishnan
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2011-09-30
  7 in total

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