Literature DB >> 26542451

Targeting voltage-gated calcium channels in neurological and psychiatric diseases.

Gerald W Zamponi1.   

Abstract

Voltage-gated calcium channels are important regulators of brain, heart and muscle functions, and their dysfunction can give rise to pathophysiological conditions ranging from cardiovascular disorders to neurological and psychiatric conditions such as epilepsy, pain and autism. In the nervous system, calcium channel blockers have been used successfully to treat absence seizures, and are emerging as potential therapeutic avenues for pathologies such as pain, Parkinson disease, addiction and anxiety. This Review provides an overview of calcium channels as drug targets for nervous system disorders, and discusses potential challenges and opportunities for the development of new clinically effective calcium channel inhibitors.

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Year:  2015        PMID： 26542451     DOI： 10.1038/nrd.2015.5

Source DB:  PubMed          Journal:  Nat Rev Drug Discov        ISSN： 1474-1776            Impact factor:   84.694


  242 in total

1.  Ablation of P/Q-type Ca(2+) channel currents, altered synaptic transmission, and progressive ataxia in mice lacking the alpha(1A)-subunit.

Authors:  K Jun; E S Piedras-Rentería; S M Smith; D B Wheeler; S B Lee; T G Lee; H Chin; M E Adams; R H Scheller; R W Tsien; H S Shin
Journal:  Proc Natl Acad Sci U S A       Date:  1999-12-21       Impact factor: 11.205

2.  Signaling to the nucleus by an L-type calcium channel-calmodulin complex through the MAP kinase pathway.

Authors:  R E Dolmetsch; U Pajvani; K Fife; J M Spotts; M E Greenberg
Journal:  Science       Date:  2001-10-12       Impact factor: 47.728

3.  Lack of the burst firing of thalamocortical relay neurons and resistance to absence seizures in mice lacking alpha(1G) T-type Ca(2+) channels.

Authors:  D Kim; I Song; S Keum; T Lee; M J Jeong; S S Kim; M W McEnery; H S Shin
Journal:  Neuron       Date:  2001-07-19       Impact factor: 17.173

4.  Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cells.

Authors:  M Göttlicher; S Minucci; P Zhu; O H Krämer; A Schimpf; S Giavara; J P Sleeman; F Lo Coco; C Nervi; P G Pelicci; T Heinzel
Journal:  EMBO J       Date:  2001-12-17       Impact factor: 11.598

5.  Genetic enhancement of thalamocortical network activity by elevating alpha 1g-mediated low-voltage-activated calcium current induces pure absence epilepsy.

Authors:  Wayne L Ernst; Yi Zhang; Jong W Yoo; Sara J Ernst; Jeffrey L Noebels
Journal:  J Neurosci       Date:  2009-02-11       Impact factor: 6.167

6.  Differential role of N-type calcium channel splice isoforms in pain.

Authors:  Christophe Altier; Camila S Dale; Alexandra E Kisilevsky; Kevin Chapman; Andrew J Castiglioni; Elizabeth A Matthews; Rhian M Evans; Anthony H Dickenson; Diane Lipscombe; Nathalie Vergnolle; Gerald W Zamponi
Journal:  J Neurosci       Date:  2007-06-13       Impact factor: 6.167

7.  Upregulation of the T-type calcium current in small rat sensory neurons after chronic constrictive injury of the sciatic nerve.

Authors:  Miljen M Jagodic; Sriyani Pathirathna; Pavle M Joksovic; WooYong Lee; Michael T Nelson; Ajit K Naik; Peihan Su; Vesna Jevtovic-Todorovic; Slobodan M Todorovic
Journal:  J Neurophysiol       Date:  2008-04-16       Impact factor: 2.714

8.  Rebound burst firing in the reticular thalamus is not essential for pharmacological absence seizures in mice.

Authors:  Seung Eun Lee; Jaekwang Lee; Charles Latchoumane; Boyoung Lee; Soo-Jin Oh; Zahangir Alam Saud; Cheongdahm Park; Ning Sun; Eunji Cheong; Chien-Chang Chen; Eui-Ju Choi; C Justin Lee; Hee-Sup Shin
Journal:  Proc Natl Acad Sci U S A       Date:  2014-07-28       Impact factor: 11.205

9.  Effects of nimodipine and other calcium channel antagonists in alcohol-preferring AA rats.

Authors:  R De Beun; R Schneider; A Klein; A Lohmann; J De Vry
Journal:  Alcohol       Date:  1996 May-Jun       Impact factor: 2.405

10.  Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary α2δ-1 subunits.

Authors:  John S Cassidy; Laurent Ferron; Ivan Kadurin; Wendy S Pratt; Annette C Dolphin
Journal:  Proc Natl Acad Sci U S A       Date:  2014-06-02       Impact factor: 11.205
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  114 in total

1.  Cryo-EM structures of apo and antagonist-bound human Cav3.1.

Authors:  Yanyu Zhao; Gaoxingyu Huang; Qiurong Wu; Kun Wu; Ruiqi Li; Jianlin Lei; Xiaojing Pan; Nieng Yan
Journal:  Nature       Date:  2019-11-25       Impact factor: 49.962

2.  Impaired chromaffin cell excitability and exocytosis in autistic Timothy syndrome TS2-neo mouse rescued by L-type calcium channel blockers.

Authors:  Chiara Calorio; Daniela Gavello; Laura Guarina; Chiara Salio; Marco Sassoè-Pognetto; Chiara Riganti; Federico Tommaso Bianchi; Nadja T Hofer; Petronel Tuluc; Gerald J Obermair; Paola Defilippi; Fiorella Balzac; Emilia Turco; Glenna C Bett; Randall L Rasmusson; Emilio Carbone
Journal:  J Physiol       Date:  2019-01-28       Impact factor: 5.182

3.  Deletion of Voltage-Gated Calcium Channels in Astrocytes during Demyelination Reduces Brain Inflammation and Promotes Myelin Regeneration in Mice.

Authors:  Norma N Zamora; Veronica T Cheli; Diara A Santiago González; Rensheng Wan; Pablo M Paez
Journal:  J Neurosci       Date:  2020-03-13       Impact factor: 6.167

4.  Upconversion Nanoparticle-Mediated Optogenetics.

Authors:  Zhigao Yi; Angelo H All; Xiaogang Liu
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 5.  Recent advances in the development of T-type calcium channel blockers for pain intervention.

Authors:  Terrance P Snutch; Gerald W Zamponi
Journal:  Br J Pharmacol       Date:  2017-07-12       Impact factor: 8.739

Review 6.  Breaking barriers to novel analgesic drug development.

Authors:  Ajay S Yekkirala; David P Roberson; Bruce P Bean; Clifford J Woolf
Journal:  Nat Rev Drug Discov       Date:  2017-06-09       Impact factor: 84.694

7.  Effects of the T-type calcium channel antagonist Z944 on paired associates learning and locomotor activity in rats treated with the NMDA receptor antagonist MK-801.

Authors:  Andrew J Roebuck; Wendie N Marks; Max C Liu; Nimra B Tahir; Nadine K Zabder; Terrance P Snutch; John G Howland
Journal:  Psychopharmacology (Berl)       Date:  2018-09-24       Impact factor: 4.530

8.  Genome-wide meta-analysis identifies a novel susceptibility signal at CACNA2D3 for nicotine dependence.

Authors:  Xianyong Yin; Chris Bizon; Jeffrey Tilson; Yuan Lin; Ian R Gizer; Cindy L Ehlers; Kirk C Wilhelmsen
Journal:  Am J Med Genet B Neuropsychiatr Genet       Date:  2017-04-25       Impact factor: 3.568

9.  Surfen is a broad-spectrum calcium channel inhibitor with analgesic properties in mouse models of acute and chronic inflammatory pain.

Authors:  Paula Rivas-Ramirez; Vinicius M Gadotti; Gerald W Zamponi; Norbert Weiss
Journal:  Pflugers Arch       Date:  2017-06-30       Impact factor: 3.657

10.  The HOOK region of β subunits controls gating of voltage-gated Ca2+ channels by electrostatically interacting with plasma membrane.

Authors:  Cheon-Gyu Park; Byung-Chang Suh
Journal:  Channels (Austin)       Date:  2017-06-01       Impact factor: 2.581
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