Literature DB >> 10400804

E4ORF3 requirement for achieving long-term transgene expression from the cytomegalovirus promoter in adenovirus vectors.

D Armentano1, M P Smith, C C Sookdeo, J Zabner, M A Perricone, J A St George, S C Wadsworth, R J Gregory.   

Abstract

Analysis of transgene expression under the control of the cytomegalovirus (CMV) promoter from adenovirus vectors in which the E4 region was modified indicated that E4ORF3 is required for long-term expression in the murine lung. CMV promoter truncation led to the persistence of expression in the absence of E4, thus eliminating the ORF3 requirement.

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Year:  1999        PMID： 10400804      PMCID： PMC112791     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  21 in total

1.  Novel role for E4 region genes in protection of adenovirus vectors from lysis by cytotoxic T lymphocytes.

Authors:  J M Kaplan; D Armentano; A Scaria; L A Woodworth; S E Pennington; S C Wadsworth; A E Smith; R J Gregory
Journal:  J Virol       Date:  1999-05       Impact factor: 5.103

2.  Formation of several specific nucleoprotein complexes on the human cytomegalovirus immediate early enhancer.

Authors:  H H Niller; L Hennighausen
Journal:  Nucleic Acids Res       Date:  1991-07-11       Impact factor: 16.971

3.  The cytomegalovirus enhancer: a pan-active control element in transgenic mice.

Authors:  E V Schmidt; G Christoph; R Zeller; P Leder
Journal:  Mol Cell Biol       Date:  1990-08       Impact factor: 4.272

4.  Redundant control of adenovirus late gene expression by early region 4.

Authors:  E Bridge; G Ketner
Journal:  J Virol       Date:  1989-02       Impact factor: 5.103

5.  Human adenovirus encodes two proteins which have opposite effects on accumulation of alternatively spliced mRNAs.

Authors:  K Nordqvist; K Ohman; G Akusjärvi
Journal:  Mol Cell Biol       Date:  1994-01       Impact factor: 4.272

6.  A very strong enhancer is located upstream of an immediate early gene of human cytomegalovirus.

Authors:  M Boshart; F Weber; G Jahn; K Dorsch-Häsler; B Fleckenstein; W Schaffner
Journal:  Cell       Date:  1985-06       Impact factor: 41.582

7.  Adenovirus early region 4 encodes two gene products with redundant effects in lytic infection.

Authors:  M M Huang; P Hearing
Journal:  J Virol       Date:  1989-06       Impact factor: 5.103

8.  Inactivation of E2a in recombinant adenoviruses improves the prospect for gene therapy in cystic fibrosis.

Authors:  Y Yang; F A Nunes; K Berencsi; E Gönczöl; J F Engelhardt; J M Wilson
Journal:  Nat Genet       Date:  1994-07       Impact factor: 38.330

9.  Targeting of adenovirus E1A and E4-ORF3 proteins to nuclear matrix-associated PML bodies.

Authors:  T Carvalho; J S Seeler; K Ohman; P Jordan; U Pettersson; G Akusjärvi; M Carmo-Fonseca; A Dejean
Journal:  J Cell Biol       Date:  1995-10       Impact factor: 10.539

10.  The transcription factor YY1 binds to negative regulatory elements in the human cytomegalovirus major immediate early enhancer/promoter and mediates repression in non-permissive cells.

Authors:  R Liu; J Baillie; J G Sissons; J H Sinclair
Journal:  Nucleic Acids Res       Date:  1994-07-11       Impact factor: 16.971
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  5 in total

1.  Diverse roles for E4orf3 at late times of infection revealed in an E1B 55-kilodalton protein mutant background.

Authors:  Robin N Shepard; David A Ornelles
Journal:  J Virol       Date:  2004-09       Impact factor: 5.103

2.  Development and characterization of novel empty adenovirus capsids and their impact on cellular gene expression.

Authors:  Jackie L Stilwell; Douglas M McCarty; Atsuko Negishi; Richard Superfine; R Jude Samulski
Journal:  J Virol       Date:  2003-12       Impact factor: 5.103

3.  Variables affecting in vivo performance of high-capacity adenovirus vectors.

Authors:  Gudrun Schiedner; Sabine Hertel; Marion Johnston; Volker Biermann; Volker Dries; Stefan Kochanek
Journal:  J Virol       Date:  2002-02       Impact factor: 5.103

4.  Viral and cellular factors that target the promyelocytic leukemia oncogenic domains strongly activate a glucocorticoid-responsive promoter.

Authors:  S Wienzek; M Dobbelstein
Journal:  J Virol       Date:  2001-06       Impact factor: 5.103

5.  Suppression of leaky expression of adenovirus genes by insertion of microRNA-targeted sequences in the replication-incompetent adenovirus vector genome.

Authors:  Kahori Shimizu; Fuminori Sakurai; Kyoko Tomita; Yasuhito Nagamoto; Shin-Ichiro Nakamura; Kazufumi Katayama; Masashi Tachibana; Kenji Kawabata; Hiroyuki Mizuguchi
Journal:  Mol Ther Methods Clin Dev       Date:  2014-09-03       Impact factor: 6.698
  5 in total

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