Literature DB >> 10196353

Novel role for E4 region genes in protection of adenovirus vectors from lysis by cytotoxic T lymphocytes.

J M Kaplan1, D Armentano, A Scaria, L A Woodworth, S E Pennington, S C Wadsworth, A E Smith, R J Gregory.   

Abstract

Target cells infected with adenovirus (Ad) vectors containing intact E3 and E4 regions were found to be relatively resistant to lysis by Ad-specific cytotoxic T lymphocytes. Elements from both the E3 and the E4 regions were required for this effect, leading to the identification of a previously undescribed role for E4 gene products in resistance to cytolysis.

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Year:  1999        PMID： 10196353      PMCID： PMC104342     

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  23 in total

1.  Ablation of E2A in recombinant adenoviruses improves transgene persistence and decreases inflammatory response in mouse liver.

Authors:  J F Engelhardt; X Ye; B Doranz; J M Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1994-06-21       Impact factor: 11.205

2.  Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung.

Authors:  K Jooss; Y Yang; J M Wilson
Journal:  Hum Gene Ther       Date:  1996-08-20       Impact factor: 5.695

3.  Immune responses to viral antigens versus transgene product in the elimination of recombinant adenovirus-infected hepatocytes in vivo.

Authors:  Y Yang; K U Jooss; Q Su; H C Ertl; J M Wilson
Journal:  Gene Ther       Date:  1996-02       Impact factor: 5.250

4.  The adenovirus early region 4 open reading frame 6/7 protein regulates the DNA binding activity of the cellular transcription factor, E2F, through a direct complex.

Authors:  M M Huang; P Hearing
Journal:  Genes Dev       Date:  1989-11       Impact factor: 11.361

5.  Development and analysis of recombinant adenoviruses for gene therapy of cystic fibrosis.

Authors:  D P Rich; L A Couture; L M Cardoza; V M Guiggio; D Armentano; P C Espino; K Hehir; M J Welsh; A E Smith; R J Gregory
Journal:  Hum Gene Ther       Date:  1993-08       Impact factor: 5.695

6.  Adenovirus E4orf4 protein binds to protein phosphatase 2A, and the complex down regulates E1A-enhanced junB transcription.

Authors:  T Kleinberger; T Shenk
Journal:  J Virol       Date:  1993-12       Impact factor: 5.103

7.  Characterization of an adenovirus gene transfer vector containing an E4 deletion.

Authors:  D Armentano; C C Sookdeo; K M Hehir; R J Gregory; J A St George; G A Prince; S C Wadsworth; A E Smith
Journal:  Hum Gene Ther       Date:  1995-10       Impact factor: 5.695

8.  Specificity of the mouse cytotoxic T lymphocyte response to adenovirus 5. E1A is immunodominant in H-2b, but not in H-2d or H-2k mice.

Authors:  F C Rawle; B B Knowles; R P Ricciardi; V Brahmacheri; P Duerksen-Hughes; W S Wold; L R Gooding
Journal:  J Immunol       Date:  1991-06-01       Impact factor: 5.422

9.  Upregulation of class I major histocompatibility complex antigens by interferon gamma is necessary for T-cell-mediated elimination of recombinant adenovirus-infected hepatocytes in vivo.

Authors:  Y Yang; Z Xiang; H C Ertl; J M Wilson
Journal:  Proc Natl Acad Sci U S A       Date:  1995-08-01       Impact factor: 11.205

10.  The 10,400- and 14,500-dalton proteins encoded by region E3 of adenovirus function together to protect many but not all mouse cell lines against lysis by tumor necrosis factor.

Authors:  L R Gooding; T S Ranheim; A E Tollefson; L Aquino; P Duerksen-Hughes; T M Horton; W S Wold
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103
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  3 in total

1.  E4ORF3 requirement for achieving long-term transgene expression from the cytomegalovirus promoter in adenovirus vectors.

Authors:  D Armentano; M P Smith; C C Sookdeo; J Zabner; M A Perricone; J A St George; S C Wadsworth; R J Gregory
Journal:  J Virol       Date:  1999-08       Impact factor: 5.103

2.  Adenoviruses activate human dendritic cells without polarization toward a T-helper type 1-inducing subset.

Authors:  D Rea; F H Schagen; R C Hoeben; M Mehtali; M J Havenga; R E Toes; C J Melief; R Offringa
Journal:  J Virol       Date:  1999-12       Impact factor: 5.103

3.  Effects of the deletion of early region 4 (E4) open reading frame 1 (orf1), orf1-2, orf1-3 and orf1-4 on virus-host cell interaction, transgene expression, and immunogenicity of replicating adenovirus HIV vaccine vectors.

Authors:  Michael A Thomas; Rui Song; Thorsten Demberg; Diego A Vargas-Inchaustegui; David Venzon; Marjorie Robert-Guroff
Journal:  PLoS One       Date:  2013-10-15       Impact factor: 3.240
  3 in total

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