AIMS: The aim of this study was to determine if the bio-battery signal can predict myocardial lesion formation and depth. METHODS: Fresh bovine ventricular myocardium was immersed in a temperature-controlled bath of circulating blood. RF energy was delivered with a custom generator to a catheter electrode. RF energy, electrode temperature, bio-battery signal and tissue impedance were displayed and recorded. A copper return plate was placed in the bath. RESULTS: When 50 volts of constant RF energy was terminated at a 20, 40, or 60% decline from the maximum bio-battery signal, the lesion depth was 4 +/- 0.4 mm. When RF energy application was terminated later, at a point characterized by a brief change of slope of the bio-battery signal, the lesions measured 7.8 +/- 1.4 mm in depth. This "bump" occurred before a rapid impedance rise. CONCLUSION: The depth of lesions created at the "bump" point was almost two-fold deeper than those at the termination points of 20, 40 and 60% bio-battery decrease (p = 0.0001). When RF energy was terminated at the rapid impedance rise the lesions were similar in depth, 8.2 +/- 0.9 mm, to those obtained when RF energy was stopped at the "bump" (p = 0.28). The bio-battery signal provides a unique marker that might be useful to obtain maximum lesion depth while avoiding rapid impedance rise.
AIMS: The aim of this study was to determine if the bio-battery signal can predict myocardial lesion formation and depth. METHODS: Fresh bovine ventricular myocardium was immersed in a temperature-controlled bath of circulating blood. RF energy was delivered with a custom generator to a catheter electrode. RF energy, electrode temperature, bio-battery signal and tissue impedance were displayed and recorded. A copper return plate was placed in the bath. RESULTS: When 50 volts of constant RF energy was terminated at a 20, 40, or 60% decline from the maximum bio-battery signal, the lesion depth was 4 +/- 0.4 mm. When RF energy application was terminated later, at a point characterized by a brief change of slope of the bio-battery signal, the lesions measured 7.8 +/- 1.4 mm in depth. This "bump" occurred before a rapid impedance rise. CONCLUSION: The depth of lesions created at the "bump" point was almost two-fold deeper than those at the termination points of 20, 40 and 60% bio-battery decrease (p = 0.0001). When RF energy was terminated at the rapid impedance rise the lesions were similar in depth, 8.2 +/- 0.9 mm, to those obtained when RF energy was stopped at the "bump" (p = 0.28). The bio-battery signal provides a unique marker that might be useful to obtain maximum lesion depth while avoiding rapid impedance rise.
Authors: H Calkins; J Sousa; R el-Atassi; S Rosenheck; M de Buitleir; W H Kou; A H Kadish; J J Langberg; F Morady Journal: N Engl J Med Date: 1991-06-06 Impact factor: 91.245
Authors: M R Jazayeri; S L Hempe; J S Sra; A A Dhala; Z Blanck; S S Deshpande; B Avitall; D P Krum; C J Gilbert; M Akhtar Journal: Circulation Date: 1992-04 Impact factor: 29.690
Authors: M D Lesh; G F Van Hare; D J Schamp; W Chien; M A Lee; J C Griffin; J J Langberg; T J Cohen; K G Lurie; M M Scheinman Journal: J Am Coll Cardiol Date: 1992-05 Impact factor: 24.094
Authors: G Hindricks; W Haverkamp; H Gülker; U Rissel; T Budde; K D Richter; M Borggrefe; G Breithardt Journal: Eur Heart J Date: 1989-11 Impact factor: 29.983
Authors: H Nakagawa; K J Beckman; J H McClelland; X Wang; M Arruda; I Santoro; H A Hazlitt; I Abdalla; A Singh; H Gossinger Journal: Circulation Date: 1993-12 Impact factor: 29.690