Literature DB >> 17125405

Pregnane X receptor and natural products: beyond drug-drug interactions.

Jeff L Staudinger1, Xunshan Ding, Kristin Lichti.   

Abstract

The pregnane X receptor (PXR, NR1I2) is a member of the nuclear receptor superfamily that is activated by a myriad of compounds and natural products in clinical use. Activation of PXR represents the basis for several clinically important drug-drug interactions. Although PXR activation has undesirable effects in patients on combination therapy, it also mediates the hepatoprotective effects exhibited by some herbal remedies. This review focuses on PXR activation by natural products and the potential therapeutic opportunities presented. In particular, the biological effects of St. John's Wort, gugulipid, kava kava, Coleus forskolii, Hypoxis, Sutherlandia, qing hao, wu wei zi, gan cao and other natural products are discussed. The impact of these natural products on drug metabolism and hepatoprotection is highlighted in the context of activation and antagonism of PXR.

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Year:  2006        PMID： 17125405      PMCID： PMC2978027          DOI： 10.1517/17425255.2.6.847

Source DB:  PubMed          Journal:  Expert Opin Drug Metab Toxicol        ISSN： 1742-5255            Impact factor:   4.481


  69 in total

Review 1.  Forskolin: from an ayurvedic remedy to a modern agent.

Authors:  H P Ammon; A B Müller
Journal:  Planta Med       Date:  1985-12       Impact factor: 3.352

2.  Comparison of rifampicin with phenobarbitone for treatment of pruritus in biliary cirrhosis.

Authors:  L Bachs; A Parés; M Elena; C Piera; J Rodés
Journal:  Lancet       Date:  1989-03-18       Impact factor: 79.321

3.  Guggulsterone activates multiple nuclear receptors and induces CYP3A gene expression through the pregnane X receptor.

Authors:  Dan E Brobst; Xunshan Ding; Katrina L Creech; Bryan Goodwin; Brian Kelley; Jeff L Staudinger
Journal:  J Pharmacol Exp Ther       Date:  2004-04-01       Impact factor: 4.030

4.  Stimulation of low density lipoprotein receptor activity in liver membrane of guggulsterone treated rats.

Authors:  V Singh; S Kaul; R Chander; N K Kapoor
Journal:  Pharmacol Res       Date:  1990 Jan-Feb       Impact factor: 7.658

5.  Desmethoxyyangonin and dihydromethysticin are two major pharmacological kavalactones with marked activity on the induction of CYP3A23.

Authors:  Yuzhong Ma; Karuna Sachdeva; Jirong Liu; Michael Ford; Dongfang Yang; Ikhlas A Khan; Clinton O Chichester; Bingfang Yan
Journal:  Drug Metab Dispos       Date:  2004-07-28       Impact factor: 3.922

6.  Effect of gugulipid on bioavailability of diltiazem and propranolol.

Authors:  S S Dalvi; V K Nayak; S M Pohujani; N K Desai; N A Kshirsagar; K C Gupta
Journal:  J Assoc Physicians India       Date:  1994-06

7.  Forskolin-mediated induction of CYP3A1 mRNA expression in primary rat hepatocytes is independent of elevated intracellular cyclic AMP.

Authors:  J S Sidhu; C J Omiecinski
Journal:  J Pharmacol Exp Ther       Date:  1996-01       Impact factor: 4.030

8.  Multiple dose pharmacokinetics of oral artemisinin and comparison of its efficacy with that of oral artesunate in falciparum malaria patients.

Authors:  M Hassan Alin; M Ashton; C M Kihamia; G J Mtey; A Björkman
Journal:  Trans R Soc Trop Med Hyg       Date:  1996 Jan-Feb       Impact factor: 2.184

9.  Forskolin: unique diterpene activator of adenylate cyclase in membranes and in intact cells.

Authors:  K B Seamon; W Padgett; J W Daly
Journal:  Proc Natl Acad Sci U S A       Date:  1981-06       Impact factor: 11.205

Review 10.  The nuclear receptor superfamily: the second decade.

Authors:  D J Mangelsdorf; C Thummel; M Beato; P Herrlich; G Schütz; K Umesono; B Blumberg; P Kastner; M Mark; P Chambon; R M Evans
Journal:  Cell       Date:  1995-12-15       Impact factor: 41.582
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  27 in total

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Authors:  Steven A Kliewer
Journal:  J Clin Invest       Date:  2015-04-01       Impact factor: 14.808

2.  Nuclear Receptors in Drug Metabolism, Drug Response and Drug Interactions.

Authors:  Chandra Prakash; Baltazar Zuniga; Chung Seog Song; Shoulei Jiang; Jodie Cropper; Sulgi Park; Bandana Chatterjee
Journal:  Nucl Receptor Res       Date:  2015

3.  Endocrine disruptors provoke differential modulatory responses on androgen receptor and pregnane and xenobiotic receptor: potential implications in metabolic disorders.

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Journal:  Mol Cell Biochem       Date:  2010-09-10       Impact factor: 3.396

4.  Potential Toxicity of Complex Mixtures in Surface Waters from a Nationwide Survey of United States Streams: Identifying in Vitro Bioactivities and Causative Chemicals.

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Review 5.  Post-translational and post-transcriptional modifications of pregnane X receptor (PXR) in regulation of the cytochrome P450 superfamily.

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6.  Pregnane X Receptor Activation Attenuates Inflammation-Associated Intestinal Epithelial Barrier Dysfunction by Inhibiting Cytokine-Induced Myosin Light-Chain Kinase Expression and c-Jun N-Terminal Kinase 1/2 Activation.

Authors:  Aditya Garg; Angela Zhao; Sarah L Erickson; Subhajit Mukherjee; Aik Jiang Lau; Laurie Alston; Thomas K H Chang; Sridhar Mani; Simon A Hirota
Journal:  J Pharmacol Exp Ther       Date:  2016-07-20       Impact factor: 4.030

Review 7.  The pregnane X receptor: from bench to bedside.

Authors:  Xiaochao Ma; Jeffrey R Idle; Frank J Gonzalez
Journal:  Expert Opin Drug Metab Toxicol       Date:  2008-07       Impact factor: 4.481

8.  The traditional Chinese herbal remedy tian xian activates pregnane X receptor and induces CYP3A gene expression in hepatocytes.

Authors:  Kristin Lichti-Kaiser; Jeff L Staudinger
Journal:  Drug Metab Dispos       Date:  2008-05-12       Impact factor: 3.922

9.  Differential regulation of CYP3A4 promoter activity by a new class of natural product derivatives binding to pregnane X receptor.

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Review 10.  Activation of pregnane X receptor (PXR) and constitutive androstane receptor (CAR) by herbal medicines.

Authors:  Thomas K H Chang
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