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Literature DB >> 10322132

Activation by locus control regions?

Abstract

On the basis of homologous recombination experiments to delete the murine beta-globin locus control region (LCR) in embryonic stem cells, it was recently suggested that the LCR is not required for the activation of the murine beta-globin locus. This conclusion is in direct contradiction to the findings and conclusions that have been obtained with the human beta-globin LCR; thus the murine and human LCR may functionally be different or there may be a different interpretation of the results.

Entities: Gene Species

Mesh：

Substances：
Globins

Year: 1999 PMID： 10322132 DOI： 10.1016/S0959-437X(99)80023-9

Source DB: PubMed Journal: Curr Opin Genet Dev ISSN： 0959-437X Impact factor: 5.578

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Cited

31 in total

1. Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of chromatin assembly.

Authors: K M Leach; K Nightingale; K Igarashi; P P Levings; J D Engel; P B Becker; J Bungert
Journal: Mol Cell Biol Date: 2001-04 Impact factor: 4.272

2. Position effects are influenced by the orientation of a transgene with respect to flanking chromatin.

Authors: Y Q Feng; M C Lorincz; S Fiering; J M Greally; E E Bouhassira
Journal: Mol Cell Biol Date: 2001-01 Impact factor: 4.272

3. Mammalian linker-histone subtypes differentially affect gene expression in vivo.

Authors: Raouf Alami; Yuhong Fan; Stephanie Pack; Timothy M Sonbuchner; Arnaud Besse; Qingcong Lin; John M Greally; Arthur I Skoultchi; Eric E Bouhassira
Journal: Proc Natl Acad Sci U S A Date: 2003-04-28 Impact factor: 11.205

Review 4. Locus control regions.

Authors: Qiliang Li; Kenneth R Peterson; Xiangdong Fang; George Stamatoyannopoulos
Journal: Blood Date: 2002-11-01 Impact factor: 22.113

Activation by locus control regions?

1. Reconstitution of human beta-globin locus control region hypersensitive sites in the absence of chromatin assembly.

2. Position effects are influenced by the orientation of a transgene with respect to flanking chromatin.

3. Mammalian linker-histone subtypes differentially affect gene expression in vivo.

Review 4. Locus control regions.

Review 5. Macrophage-specific gene expression: current paradigms and future challenges.

6. Chromosomal elements regulate gene activity and chromatin structure of the human serpin gene cluster at 14q32.1.

7. Recruitment of transcription complexes to the beta-globin gene locus in vivo and in vitro.

Review 8. Control of globin gene expression during development and erythroid differentiation.

9. The human beta-globin locus control region can silence as well as activate gene expression.

10. Identification of C. elegans DAF-12-binding sites, response elements, and target genes.