Literature DB >> 10230055

Synthesis and evaluation of antimycobacterial activity of 4-phenyl-1,8-naphthyridine derivatives.

P L Ferrarini1, C Manera, C Mori, M Badawneh, G Saccomanni.   

Abstract

Some 4-phenyl-1,8-naphthyridine derivatives with a piperazino group in the 2- and/or 7-position have been synthesized and evaluated for their tuberculostatic activity. The compounds 1, 6, 10, 17b,c and 19i showed a marked activity against Mycobacterium tuberculosis H37Rv. For this series of compounds, submitted to biological screening, no structure-activity relationship can be deduced.

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Year:  1998        PMID： 10230055     DOI： 10.1016/s0014-827x(98)00094-9

Source DB:  PubMed          Journal:  Farmaco        ISSN： 0014-827X


  6 in total

1.  2,7-Bis-(trichloro-meth-yl)-1,8-naphthyridine.

Authors:  Hoong-Kun Fun; Suchada Chantrapromma; Annada C Maity; Shyamaprosad Goswami
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-02-13

2.  Unilamellar vesicles as potential capreomycin sulfate carriers: preparation and physicochemical characterization.

Authors:  Stefano Giovagnoli; Paolo Blasi; Claudia Vescovi; Giuseppe Fardella; Ione Chiappini; Luana Perioli; Maurizio Ricci; Carlo Rossi
Journal:  AAPS PharmSciTech       Date:  2004-12-31       Impact factor: 3.246

3.  An efficient Synthesis and Photophysical Properties of 1H-pyrazolo-[3,4-b]pyridine and pyrazolo[3,4-b][1,8]naphthyridines.

Authors:  Raviraj Deore; Kunal Dingore; Madhukar Jachak
Journal:  J Fluoresc       Date:  2015-09-28       Impact factor: 2.217

4.  Effects of anti-inflammatory [1, 2, 4]triazolo[4, 3-a] [1, 8]naphthyridine derivatives on human stimulated PMN and endothelial cells: an in vitro study.

Authors:  Chiara Dianzani; Massimo Collino; Margherita Gallicchio; Mario Di Braccio; Giorgio Roma; Roberto Fantozzi
Journal:  J Inflamm (Lond)       Date:  2006-03-28       Impact factor: 4.981

5.  Crystal structures of the dioxane hemisolvates of N-(7-bromo-methyl-1,8-naphthyridin-2-yl)acetamide and bis-[N-(7-di-bromo-methyl-1,8-naphthyridin-2-yl)acetamide].

Authors:  Robert Rosin; Wilhelm Seichter; Monika Mazik
Journal:  Acta Crystallogr E Crystallogr Commun       Date:  2017-09-05

6.  General pathway for a convenient one-pot synthesis of trifluoromethyl-containing 2-amino-7-alkyl(aryl/heteroaryl)-1,8-naphthyridines and fused cycloalkane analogues.

Authors:  Helio G Bonacorso; Rosália Andrighetto; Nícolas Krüger; Nilo Zanatta; Marcos A P Martins
Journal:  Molecules       Date:  2011-03-30       Impact factor: 4.411
  6 in total

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