PURPOSE: To investigate the agreement between two noninvasive methods, magnetic resonance (MR) velocity mapping and first-pass radionuclide angiography, to quantify the pulmonary-to-systemic blood flow ratio (QP/QS) in adults, adolescents, and children with left-to-right cardiac shunts. MATERIALS AND METHODS: The accuracy and precision of MR velocity mapping were studied in 12 control subjects (six men, six women) and in a phantom. MR velocity mapping and radionuclide angiography were performed on the same day in 24 patients (16 adults, two adolescents, six children; five male patients, 19 female patients). RESULTS: The mean error in QP/QS at MR velocity mapping in phantom experiments was -1% +/- 1 (mean +/- SD). In control subjects, QP/QS at MR velocity mapping was 1.03 +/- 0.03, and the cardiac index was 3.1 L/min/m2 +/- 0.2 and 3.2 L/min/m2 +/- 0.3 for women and men, respectively. In patients, QP/QS at radionuclide angiography was 14% +/- 13, higher than at MR velocity mapping. Interobserver variability was four times higher for radionuclide angiography compared with MR velocity mapping, 0% + 16 versus 0% +/- 4 (n = 12). The difference between repeated MR flow measurements in the same vessel was -1% +/- 5 (n = 36). CONCLUSION: The data suggest that MR velocity mapping is accurate and precise for measurements of shunt size over the whole range of possible QP/QS values.
PURPOSE: To investigate the agreement between two noninvasive methods, magnetic resonance (MR) velocity mapping and first-pass radionuclide angiography, to quantify the pulmonary-to-systemic blood flow ratio (QP/QS) in adults, adolescents, and children with left-to-right cardiac shunts. MATERIALS AND METHODS: The accuracy and precision of MR velocity mapping were studied in 12 control subjects (six men, six women) and in a phantom. MR velocity mapping and radionuclide angiography were performed on the same day in 24 patients (16 adults, two adolescents, six children; five male patients, 19 female patients). RESULTS: The mean error in QP/QS at MR velocity mapping in phantom experiments was -1% +/- 1 (mean +/- SD). In control subjects, QP/QS at MR velocity mapping was 1.03 +/- 0.03, and the cardiac index was 3.1 L/min/m2 +/- 0.2 and 3.2 L/min/m2 +/- 0.3 for women and men, respectively. In patients, QP/QS at radionuclide angiography was 14% +/- 13, higher than at MR velocity mapping. Interobserver variability was four times higher for radionuclide angiography compared with MR velocity mapping, 0% + 16 versus 0% +/- 4 (n = 12). The difference between repeated MR flow measurements in the same vessel was -1% +/- 5 (n = 36). CONCLUSION: The data suggest that MR velocity mapping is accurate and precise for measurements of shunt size over the whole range of possible QP/QS values.
Authors: Steffen E Petersen; Thomas Voigtländer; Karl-Friedrich Kreitner; Peter Kalden; Thomas Wittlinger; Jürgen Scharhag; Georg Horstick; Dietmar Becker; Gerhard Hommel; Manfred Thelen; Jürgen Meyer Journal: Int J Cardiovasc Imaging Date: 2002-02 Impact factor: 2.357
Authors: Elizabeth J Nett; Kevin M Johnson; Alex Frydrychowicz; Alejandro Munoz Del Rio; Eric Schrauben; Christopher J Francois; Oliver Wieben Journal: J Magn Reson Imaging Date: 2012-01-26 Impact factor: 4.813
Authors: Guido E Pieles; Gergely Szantho; Jonathan C L Rodrigues; Christopher B Lawton; A Graham Stuart; Chiara Bucciarelli-Ducci; Mark S Turner; Craig A Williams; Robert M R Tulloh; Mark C K Hamilton Journal: Eur J Appl Physiol Date: 2014-02-07 Impact factor: 3.078
Authors: Matthias Götberg; Goran K Olivecrona; Henrik Engblom; Martin Ugander; Jesper van der Pals; Einar Heiberg; Håkan Arheden; David Erlinge Journal: BMC Cardiovasc Disord Date: 2008-04-10 Impact factor: 2.298