Literature DB >> 10203703

Phosphorylcholine: friend or foe of the immune system?

W Harnett1, M M Harnett.   

Abstract

Phosphorylcholine (PC) is a structural component of a variety of prokaryotic and eukaryotic pathogens. In some cases, PC in infectious agents can benefit the infected host due to its targeting by both the innate and adaptive immune responses. However, as discussed here, PC exhibits a surprising range of immunomodulatory properties that might be to the detriment of the host.

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Year:  1999        PMID： 10203703     DOI： 10.1016/s0167-5699(98)01419-4

Source DB:  PubMed          Journal:  Immunol Today        ISSN： 0167-5699


  45 in total

Review 1.  Immune recognition of OxLDL in atherosclerosis.

Authors:  J F Kearney
Journal:  J Clin Invest       Date:  2000-06       Impact factor: 14.808

2.  Opsonization of Actinobacillus actinomycetemcomitans by immunoglobulin G antibody reactive with phosphorylcholine.

Authors:  Donald Purkall; John G Tew; Harvey A Schenkein
Journal:  Infect Immun       Date:  2002-11       Impact factor: 3.441

3.  19 A solution structure of the filarial nematode immunomodulatory protein, ES-62.

Authors:  Claire J Ackerman; Margaret M Harnett; William Harnett; Sharon M Kelly; Dmitri I Svergun; Olwyn Byron
Journal:  Biophys J       Date:  2003-01       Impact factor: 4.033

Review 4.  C-reactive protein: a critical update.

Authors:  Mark B Pepys; Gideon M Hirschfield
Journal:  J Clin Invest       Date:  2003-06       Impact factor: 14.808

5.  IL-5 links adaptive and natural immunity specific for epitopes of oxidized LDL and protects from atherosclerosis.

Authors:  Christoph J Binder; Karsten Hartvigsen; Mi-Kyung Chang; Marina Miller; David Broide; Wulf Palinski; Linda K Curtiss; Maripat Corr; Joseph L Witztum
Journal:  J Clin Invest       Date:  2004-08       Impact factor: 14.808

6.  Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregation.

Authors:  Christopher J Kuckleburg; Shaadi F Elswaifi; Thomas J Inzana; Charles J Czuprynski
Journal:  Infect Immun       Date:  2006-11-21       Impact factor: 3.441

7.  In vivo exposure of murine dendritic cell and macrophage bone marrow progenitors to the phosphorylcholine-containing filarial nematode glycoprotein ES-62 polarizes their differentiation to an anti-inflammatory phenotype.

Authors:  Helen S Goodridge; Fraser A Marshall; Emma H Wilson; Katrina M Houston; Foo Y Liew; Margaret M Harnett; William Harnett
Journal:  Immunology       Date:  2004-12       Impact factor: 7.397

Review 8.  Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62.

Authors:  Helen S Goodridge; Gillian Stepek; William Harnett; Margaret M Harnett
Journal:  Immunology       Date:  2005-07       Impact factor: 7.397

9.  Both free-living and parasitic nematodes induce a characteristic Th2 response that is dependent on the presence of intact glycans.

Authors:  Salah Tawill; Laetitia Le Goff; Fahimeda Ali; Mark Blaxter; Judith E Allen
Journal:  Infect Immun       Date:  2004-01       Impact factor: 3.441

10.  Detection and site localization of phosphorylcholine-modified peptides by NanoLC-ESI-MS/MS using precursor ion scanning and multiple reaction monitoring experiments.

Authors:  Thomas Timm; Christof Lenz; Dietrich Merkel; Christian Sadiffo; Julia Grabitzki; Jochen Klein; Guenter Lochnit
Journal:  J Am Soc Mass Spectrom       Date:  2014-12-09       Impact factor: 3.109
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