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Literature DB >> 15946247

Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62.

Helen S Goodridge¹, Gillian Stepek, William Harnett, Margaret M Harnett.

Abstract

Secretion of immunomodulatory molecules is a key strategy employed by pathogens to enable their survival in host organisms. For example, arthropod-transmitted filarial nematodes, which achieve longevity within the infected host by suppressing and modulating the host immune response, produce excretory-secretory (ES) products that have been demonstrated to possess immunomodulatory properties. In this review we discuss the immunomodulatory effects of the phosphorylcholine-containing filarial nematode-secreted glycoprotein ES-62 and describe the intracellular signal transduction pathways it targets to achieve these effects.

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Year: 2005 PMID： 15946247 PMCID： PMC1782160 DOI： 10.1111/j.1365-2567.2005.02167.x

Source DB: PubMed Journal: Immunology ISSN： 0019-2805 Impact factor: 7.397

64 in total

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