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Literature DB >> 17118985

Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregation.

Christopher J Kuckleburg¹, Shaadi F Elswaifi, Thomas J Inzana, Charles J Czuprynski.

Abstract

Histophilus somni-induced platelet aggregation was inhibited by antagonists of the platelet-activating factor (PAF) receptor but not inhibitors of PAF synthesis. In addition, H. somni cells expressing phosphorylcholine (ChoP) induced aggregation, while ChoP(-) H. somni cells did not. This suggests that H. somni ChoP may induce platelet aggregation via interactions with the PAF receptor.

Entities: Chemical Disease Species

Mesh：

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Year: 2006 PMID： 17118985 PMCID： PMC1828531 DOI： 10.1128/IAI.01177-06

Source DB: PubMed Journal: Infect Immun ISSN： 0019-9567 Impact factor: 3.441

33 in total

1. Evidence for a role for phospholipase C, but not phospholipase A2, in platelet activation in response to low concentrations of collagen.

Authors: L K Lockhart; C Pampolina; B R Nickolaychuk; A McNicol
Journal: Thromb Haemost Date: 2001-05 Impact factor: 5.249

2. The Adhesion of Rabbit Platelets to Bacteria.

Authors: R B Houlihan; A L Copley
Journal: J Bacteriol Date: 1946-10 Impact factor: 3.490

3. Antigenic diversity of Haemophilus somnus lipooligosaccharide: phase-variable accessibility of the phosphorylcholine epitope.

Authors: M D Howard; A D Cox; J N Weiser; G G Schurig; T J Inzana
Journal: J Clin Microbiol Date: 2000-12 Impact factor: 5.948

4. Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology.

Authors: Sophie Fillon; Konstantinos Soulis; Surender Rajasekaran; Heather Benedict-Hamilton; Jana N Radin; Carlos J Orihuela; Karim C El Kasmi; Gopal Murti; Deepak Kaushal; M Waleed Gaber; Joerg R Weber; Peter J Murray; Elaine I Tuomanen
Journal: J Immunol Date: 2006-11-01 Impact factor: 5.422

Expression of phosphorylcholine by Histophilus somni induces bovine platelet aggregation.

1. Evidence for a role for phospholipase C, but not phospholipase A2, in platelet activation in response to low concentrations of collagen.

2. The Adhesion of Rabbit Platelets to Bacteria.

3. Antigenic diversity of Haemophilus somnus lipooligosaccharide: phase-variable accessibility of the phosphorylcholine epitope.

4. Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology.

5. Platelet interaction with bacteria. VI. contrasting the role of fibrinogen and fibronectin.

6. Phosphorylcholine: friend or foe of the immune system?

7. Microscopic lesions associated with the isolation of Haemophilus somnus from pneumonic bovine lungs.

8. Structural analysis of the phase-variable lipooligosaccharide from Haemophilus somnus strain 738.

9. Comparison of the actions of some platelet-activating factor antagonists on platelets and aortic smooth muscles.

10. Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway.

1. The role of lipooligosaccharide phosphorylcholine in colonization and pathogenesis of Histophilus somni in cattle.

2. Histophilus somni causes extracellular trap formation by bovine neutrophils and macrophages.