Long-term survival after permanent pacemaker implantation in young adults: 30 year experience.

The goal of the present study was to determine the etiology of conduction disease and long-term outcome for young adults who undergo permanent pacemaker implantation. Permanent pacing was performed in 232 patients aged 21-50 years, 135 males and 97 females, from 1965 through 1995. One hundred and twenty-six subjects (54%) had evidence of structural heart disease, while idiopathic conduction disease accounted for 46%. About half (54%) of 106 patients with structural heart disease had surgically induced heart block. Pacing mode at primary implantation was single chamber in 65% and dual chamber in 35%. Follow-up ranged from 12-387 months, with a mean of 104-months. At the last follow-up, 133 of 232 patients (57%) were alive, 40 (17%) had died, 30 (13%) were lost to follow-up, 26 (11%) were transferred elsewhere, and 3 (1%) explanted. Patients with sick sinus syndrome had similar outcomes to those with AV block. There was a sharp decline in survival during the first six months; 7.5% of the sample died within the first year following their first pacemaker operation. After the first year, the decline in survival slowed and 70% of the patients could be expected to survive beyond 20 years. The overall survival of young patients without structural heart disease who received a permanent pacemaker was comparable to an age- and sex-matched control population, while patients with structural heart disease performed significantly worse than the control population.