Literature DB >> 10136825

Management of coeliac disease: a changing diagnostic approach but what value in follow up?

M Acalovschi1, V Jayanthi, C S Probert, J F Mayberry.   

Abstract

OBJECTIVE: To assess the management of patients with coeliac disease in relation to a change in diagnostic method from jejunal suction biopsy to endoscopic biopsy.
DESIGN: 16 item questionnaire survey of consultant members of the British Society of Gastroenterology.
SUBJECTS: 359 consultant physician and gastroenterologist members of the society. MAIN MEASURES: Type of routine biopsy; repeat biopsy after gluten withdrawal; gluten rechallenge; follow up measurements; screening for malignancy; and methods of follow up, including special clinics.
RESULTS: 270(70%) members replied; 216(80%) diagnosed coeliac disease routinely by endoscopic duodenal biopsy, 30(11%) by jejunal capsule biopsy, and the remainder by either method. Only 156(58%) repeated the biopsy after gluten withdrawal, though more did so for duodenal than jejunal biopsies (134/216, 62% v 13/30, 43%; p < 0.02). Follow up biopsies featured more duodenal than jejunal biopsies (133/156, 82% v 23/156, 15%; p < 0.02). Regular follow up included assessments of weight (259, 96%) and full blood count (238, 88%) but limited assessment of serum B-12 and folate (120, 44%) and calcium (105, 39%) concentrations. Routine screening for malignancy is not performed, and there are few specialist clinics. 171(63%) respondents thought that patients should be followed up by a hospital specialist and 58(21%) by family doctors.
CONCLUSIONS: The practice of diagnosing coeliac disease varies appreciably from that in many standard texts. Many patients could be effectively cared for by their family doctor. IMPLICATIONS: The British Society of Gastroenterology should support such management by family doctors by providing clear guidelines for them.

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Mesh:

Year:  1992        PMID: 10136825      PMCID: PMC1056802          DOI: 10.1136/qshc.1.1.26

Source DB:  PubMed          Journal:  Qual Health Care        ISSN: 0963-8172


  12 in total

1.  Small bowel biopsy for malabsorption: comparison of the diagnostic adequacy of endoscopic forceps and capsule biopsy specimens.

Authors:  A S Mee; M Burke; A G Vallon; J Newman; P B Cotton
Journal:  Br Med J (Clin Res Ed)       Date:  1985-09-21

2.  Haemangioma of the cord: further cause of raised maternal serum and liquor alpha-fetoprotein.

Authors:  A J Barson; P Donnai; A Ferguson; D Donnai; A P Read
Journal:  Br Med J       Date:  1980-11-08

3.  Controlled, randomised trial of the effect of dietary fat on blood pressure.

Authors:  P Puska; J M Iacono; A Nissinen; H J Korhonen; E Vartianinen; P Pietinen; R Dougherty; U Leino; M Mutanen; S Moisio; J Huttunen
Journal:  Lancet       Date:  1983-01-01       Impact factor: 79.321

4.  Changes in clinical features of coeliac disease in adults in Edinburgh and the Lothians 1960-79.

Authors:  R F Logan; G Tucker; E A Rifkind; R C Heading; A Ferguson
Journal:  Br Med J (Clin Res Ed)       Date:  1983-01-08

5.  Malignancy in coeliac disease--effect of a gluten free diet.

Authors:  G K Holmes; P Prior; M R Lane; D Pope; R N Allan
Journal:  Gut       Date:  1989-03       Impact factor: 23.059

6.  Reintroduction of gluten in adults and children with treated coeliac disease.

Authors:  P J Kumar; D P O'Donoghue; K Stenson; A M Dawson
Journal:  Gut       Date:  1979-09       Impact factor: 23.059

7.  Endoscopic demonstration of loss of duodenal folds in the diagnosis of celiac disease.

Authors:  E Brocchi; G R Corazza; G Caletti; E A Treggiari; L Barbara; G Gasbarrini
Journal:  N Engl J Med       Date:  1988-09-22       Impact factor: 91.245

8.  Atypical coeliac disease found with serologic screening.

Authors:  P Collin; O Hällström; M Mäki; M Viander; O Keyriläinen
Journal:  Scand J Gastroenterol       Date:  1990-03       Impact factor: 2.423

9.  Prevalence and "incidence" of celiac disease in Edinburgh and the Lothian region of Scotland.

Authors:  R F Logan; E A Rifkind; A Busuttil; H M Gilmour; A Ferguson
Journal:  Gastroenterology       Date:  1986-02       Impact factor: 22.682

10.  Rectal gluten challenge and diagnosis of coeliac disease.

Authors:  D E Loft; M N Marsh; P T Crowe
Journal:  Lancet       Date:  1990-06-02       Impact factor: 79.321

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  1 in total

Review 1.  Celiac disease: risk assessment, diagnosis, and monitoring.

Authors:  Mala Setty; Leonardo Hormaza; Stefano Guandalini
Journal:  Mol Diagn Ther       Date:  2008       Impact factor: 4.074

  1 in total

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