Literature DB >> 10103203

Development of resistance during antimicrobial therapy caused by insertion sequence interruption of porin genes.

S Hernández-Allés1, V J Benedí, L Martínez-Martínez, A Pascual, A Aguilar, J M Tomás, S Albertí.   

Abstract

We have demonstrated by using an in vitro approach that interruption of the OmpK36 porin gene by insertion sequences (ISs) is a common type of mutation that causes loss of porin expression and increased resistance to cefoxitin in Klebsiella pneumoniae. This mechanism also operates in vivo: of 13 porin-deficient cefoxitin-resistant clinical isolates of K. pneumoniae, 4 presented ISs in their ompK36 gene.

Entities:  

Mesh：

Substances：

Year:  1999        PMID： 10103203      PMCID： PMC89229     

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  18 in total

1.  Loss of OmpC porin in a strain of Salmonella typhimurium causes increased resistance to cephalosporins during therapy.

Authors:  A A Medeiros; T F O'Brien; E Y Rosenberg; H Nikaido
Journal:  J Infect Dis       Date:  1987-11       Impact factor: 5.226

2.  Porin expression in clinical isolates of Klebsiella pneumoniae.

Authors:  Santiago Hernández-Allés; Sebastián Albertí; Dolores Álvarez; Antonio Doménech-Sánchez; Luis Martínez-Martínez; José Gil; Juan M Tomás; Vicente J Benedí
Journal:  Microbiology       Date:  1999-03       Impact factor: 2.777

Review 3.  The evolutionary implications of mobile genetic elements.

Authors:  M Syvanen
Journal:  Annu Rev Genet       Date:  1984       Impact factor: 16.830

4.  Insertion of IS2 creates a novel ampC promoter in Escherichia coli.

Authors:  B Jaurin; S Normark
Journal:  Cell       Date:  1983-03       Impact factor: 41.582

5.  Solubilization of the cytoplasmic membrane of Escherichia coli by the ionic detergent sodium-lauryl sarcosinate.

Authors:  C Filip; G Fletcher; J L Wulff; C F Earhart
Journal:  J Bacteriol       Date:  1973-09       Impact factor: 3.490

6.  In vivo selection of porin-deficient mutants of Klebsiella pneumoniae with increased resistance to cefoxitin and expanded-spectrum-cephalosporins.

Authors:  L Martínez-Martínez; S Hernández-Allés; S Albertí; J M Tomás; V J Benedi; G A Jacoby
Journal:  Antimicrob Agents Chemother       Date:  1996-02       Impact factor: 5.191

7.  Reduced expression of outer-membrane proteins in beta-lactam-resistant mutants of Enterobacter cloacae.

Authors:  R Aggeler; R L Then; R Ghosh
Journal:  J Gen Microbiol       Date:  1987-12

8.  Emergence of bacterial resistance to cefamandole in vivo due to outer membrane protein deficiency.

Authors:  J A van de Klundert; M H van Gestel; G Meerdink; S de Marie
Journal:  Eur J Clin Microbiol Infect Dis       Date:  1988-12       Impact factor: 3.267

9.  Outer membrane profiles of clonally related Klebsiella pneumoniae isolates from clinical samples and activities of cephalosporins and carbapenems.

Authors:  C Ardanuy; J Liñares; M A Domínguez; S Hernández-Allés; V J Benedí; L Martínez-Martínez
Journal:  Antimicrob Agents Chemother       Date:  1998-07       Impact factor: 5.191

10.  A porin from Klebsiella pneumoniae: sequence homology, three-dimensional model, and complement binding.

Authors:  S Albertí; F Rodríquez-Quiñones; T Schirmer; G Rummel; J M Tomás; J P Rosenbusch; V J Benedí
Journal:  Infect Immun       Date:  1995-03       Impact factor: 3.441
View more
  28 in total

1.  Antibiotic resistance rates and phenotypes among isolates of Enterobacteriaceae in French extra-hospital practice.

Authors:  C Quentin; C Arpin; V Dubois; C André; I Lagrange; I Fischer; J-P Brochet; F Grobost; J Jullin; B Dutilh; G Larribet; P Noury
Journal:  Eur J Clin Microbiol Infect Dis       Date:  2004-02-19       Impact factor: 3.267

2.  Wide dissemination of a carbapenemase plasmid among gram-negative bacteria: implications of the variable phenotype.

Authors:  Björn Espedido; Jonathan Iredell; Lee Thomas; Anna Zelynski
Journal:  J Clin Microbiol       Date:  2005-09       Impact factor: 5.948

Review 3.  Modes and modulations of antibiotic resistance gene expression.

Authors:  Florence Depardieu; Isabelle Podglajen; Roland Leclercq; Ekkehard Collatz; Patrice Courvalin
Journal:  Clin Microbiol Rev       Date:  2007-01       Impact factor: 26.132

4.  Outbreak of meropenem-resistant Serratia marcescens comediated by chromosomal AmpC beta-lactamase overproduction and outer membrane protein loss.

Authors:  Borum Suh; Il Kwon Bae; Juwon Kim; Seok Hoon Jeong; Dongeun Yong; Kyungwon Lee
Journal:  Antimicrob Agents Chemother       Date:  2010-09-27       Impact factor: 5.191

Review 5.  The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteria.

Authors:  Xian-Zhi Li; Patrick Plésiat; Hiroshi Nikaido
Journal:  Clin Microbiol Rev       Date:  2015-04       Impact factor: 26.132

6.  Characterization of a large outbreak by CTX-M-1-producing Klebsiella pneumoniae and mechanisms leading to in vivo carbapenem resistance development.

Authors:  Ana Mena; Virginia Plasencia; Laura García; Olga Hidalgo; José Ignacio Ayestarán; Sebastián Alberti; Nuria Borrell; José L Pérez; Antonio Oliver
Journal:  J Clin Microbiol       Date:  2006-08       Impact factor: 5.948

7.  Enhanced expression of the multidrug efflux pumps AcrAB and AcrEF associated with insertion element transposition in Escherichia coli mutants Selected with a fluoroquinolone.

Authors:  A S Jellen-Ritter; W V Kern
Journal:  Antimicrob Agents Chemother       Date:  2001-05       Impact factor: 5.191

8.  IS26-mediated amplification of blaOXA-1 and blaCTX-M-15 with concurrent outer membrane porin disruption associated with de novo carbapenem resistance in a recurrent bacteraemia cohort.

Authors:  William C Shropshire; Samuel L Aitken; Reed Pifer; Jiwoong Kim; Micah M Bhatti; Xiqi Li; Awdhesh Kalia; Jessica Galloway-Peña; Pranoti Sahasrabhojane; Cesar A Arias; David E Greenberg; Blake M Hanson; Samuel A Shelburne
Journal:  J Antimicrob Chemother       Date:  2021-01-19       Impact factor: 5.790

9.  Identification and characterization of a new porin gene of Klebsiella pneumoniae: its role in beta-lactam antibiotic resistance.

Authors:  A Doménech-Sánchez; S Hernández-Allés; L Martínez-Martínez; V J Benedí; S Albertí
Journal:  J Bacteriol       Date:  1999-05       Impact factor: 3.490

Review 10.  Dead bugs don't mutate: susceptibility issues in the emergence of bacterial resistance.

Authors:  Charles W Stratton
Journal:  Emerg Infect Dis       Date:  2003-01       Impact factor: 6.883
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.