BACKGROUND: We examined the possible predictive role of preoperative C-reactive protein (CRP) levels for postoperative infections in patients who have cardiac operations. METHODS: CRP levels were determined on the day before the operation and on postoperative days 1 to 4 and 6 in 593 consecutive patients. Furthermore, we documented infectious disease-related data. RESULTS: Patients in whom an infection developed during the postoperative course (n = 87) had significantly higher CRP levels on the day before operation (17.8+/-3.9 mg/L compared with 7.7+/-0.7 mg/L; p<0.001) and on postoperative days 4 and 6. The incidence of postoperative infections was significantly higher in patients with increased preoperative CRP levels than in those with normal preoperative CRP levels (25.3% versus 11.2%, respectively; p<0.001). Furthermore, patients with higher preoperative CRP levels had a significantly longer postoperative hospital stay than those with normal preoperative CRP levels (10.8+/-1.2 days versus 7.8+/-0.3 days; p<0.001). Multivariate analysis, including classic risk factors and increased preoperative CRP levels, demonstrated that higher preoperative CRP was the most important variable predicting postoperative infection (odds ratio = 2.7; 95% confidence interval = 1.7 to 4.3; p<0.001). CONCLUSIONS: Patients with higher preoperative CRP levels are at increased risk for postoperative infections. Therefore, preoperative measurement of CRP might be a useful, predictive marker in risk stratification for postoperative infections in patients scheduled for cardiac operations.
BACKGROUND: We examined the possible predictive role of preoperative C-reactive protein (CRP) levels for postoperative infections in patients who have cardiac operations. METHODS:CRP levels were determined on the day before the operation and on postoperative days 1 to 4 and 6 in 593 consecutive patients. Furthermore, we documented infectious disease-related data. RESULTS:Patients in whom an infection developed during the postoperative course (n = 87) had significantly higher CRP levels on the day before operation (17.8+/-3.9 mg/L compared with 7.7+/-0.7 mg/L; p<0.001) and on postoperative days 4 and 6. The incidence of postoperative infections was significantly higher in patients with increased preoperative CRP levels than in those with normal preoperative CRP levels (25.3% versus 11.2%, respectively; p<0.001). Furthermore, patients with higher preoperative CRP levels had a significantly longer postoperative hospital stay than those with normal preoperative CRP levels (10.8+/-1.2 days versus 7.8+/-0.3 days; p<0.001). Multivariate analysis, including classic risk factors and increased preoperative CRP levels, demonstrated that higher preoperative CRP was the most important variable predicting postoperative infection (odds ratio = 2.7; 95% confidence interval = 1.7 to 4.3; p<0.001). CONCLUSIONS:Patients with higher preoperative CRP levels are at increased risk for postoperative infections. Therefore, preoperative measurement of CRP might be a useful, predictive marker in risk stratification for postoperative infections in patients scheduled for cardiac operations.
Authors: Veysel Sahin; Mehmet Besir Akpinar; Erol Sevim; Ihsan Sami Uyar; Ahmet Feyzi Abacilar; Halil Uc; Funda Tetik; Ertan Damar; Faik Fevzi Okur; Emin Alp Alayunt Journal: Int J Clin Exp Med Date: 2015-03-15
Authors: William K Oelsner; Stephen M Engstrom; Michael A Benvenuti; Thomas J An; Richard A Jacobson; Gregory G Polkowski; Jonathan G Schoenecker Journal: J Arthroplasty Date: 2016-07-15 Impact factor: 4.757
Authors: Kenneth J Mukamal; Jennifer K Pai; Ellen S O'Meara; Russell P Tracy; Bruce M Psaty; Lewis H Kuller; Anne B Newman; Sachin Yende; Gary C Curhan; David S Siscovick; Eric B Rimm Journal: Respirology Date: 2009-11-23 Impact factor: 6.424