PURPOSE: The present study was designed to evaluate the relationship between the preoperative C-reactive protein levels and the incidence of postoperative infectious complications in patients undergoing colorectal surgery. METHODS: This study was a retrospective cohort study of a consecutive series of 464 patients who underwent elective colorectal resection between April 2010 and March 2012. We evaluated the patients' preoperative conditions, including the preoperative C-reactive protein levels, surgical content, and incidence of postoperative infectious complications. RESULTS: Postoperative infectious complications occurred in 133 patients (28.7 %). In the univariate analysis, male gender, rectal surgery, open surgery, elevated preoperative white blood cell counts, elevated preoperative C-reactive protein levels, extended operative times, large amounts of blood loss during surgery, and ostomy formation were found to be significantly associated with the incidence of postoperative infectious complications. In the multivariate analysis, elevated preoperative C-reactive protein levels (OR per mg/dl = 1.17, 95 % CI = 1.02-1.37, P = 0.02) and large amounts of blood loss during surgery (OR per 100 g = 1.13, 95 % CI = 1.06-1.23, P < 0.01) were found to be independently associated with the incidence of postoperative infectious complications. CONCLUSIONS: This study provides evidence of an association between the preoperative C-reactive protein level and the incidence of postoperative infectious complications following colorectal surgery, which should be further confirmed in prospective and appropriately designed studies.
PURPOSE: The present study was designed to evaluate the relationship between the preoperative C-reactive protein levels and the incidence of postoperative infectious complications in patients undergoing colorectal surgery. METHODS: This study was a retrospective cohort study of a consecutive series of 464 patients who underwent elective colorectal resection between April 2010 and March 2012. We evaluated the patients' preoperative conditions, including the preoperative C-reactive protein levels, surgical content, and incidence of postoperative infectious complications. RESULTS:Postoperative infectious complications occurred in 133 patients (28.7 %). In the univariate analysis, male gender, rectal surgery, open surgery, elevated preoperative white blood cell counts, elevated preoperative C-reactive protein levels, extended operative times, large amounts of blood loss during surgery, and ostomy formation were found to be significantly associated with the incidence of postoperative infectious complications. In the multivariate analysis, elevated preoperative C-reactive protein levels (OR per mg/dl = 1.17, 95 % CI = 1.02-1.37, P = 0.02) and large amounts of blood loss during surgery (OR per 100 g = 1.13, 95 % CI = 1.06-1.23, P < 0.01) were found to be independently associated with the incidence of postoperative infectious complications. CONCLUSIONS: This study provides evidence of an association between the preoperative C-reactive protein level and the incidence of postoperative infectious complications following colorectal surgery, which should be further confirmed in prospective and appropriately designed studies.
Authors: F Rovera; G Dionigi; L Boni; C Piscopo; P Masciocchi; M G Alberio; G Carcano; M Diurni; R Dionigi Journal: Surg Oncol Date: 2007-11-26 Impact factor: 3.279
Authors: Rene Warschkow; Ulrich Beutner; Thomas Steffen; Sascha A Müller; Bruno M Schmied; Ulrich Güller; Ignazio Tarantino Journal: Ann Surg Date: 2012-08 Impact factor: 12.969
Authors: Robert L Smith; Jamie K Bohl; Shannon T McElearney; Charles M Friel; Margaret M Barclay; Robert G Sawyer; Eugene F Foley Journal: Ann Surg Date: 2004-05 Impact factor: 12.969
Authors: T Welsch; S A Müller; A Ulrich; A Kischlat; U Hinz; P Kienle; M W Büchler; J Schmidt; B M Schmied Journal: Int J Colorectal Dis Date: 2007-07-17 Impact factor: 2.571
Authors: Luigi De Magistris; Brice Paquette; David Orry; Olivier Facy; Giovanni Di Giacomo; Patrick Rat; Christine Binquet; Pablo Ortega-Deballon Journal: Int J Colorectal Dis Date: 2016-06-29 Impact factor: 2.571
Authors: Vincent T Hoek; Cloë L Sparreboom; Albert M Wolthuis; Anand G Menon; Gert-Jan Kleinrensink; André D'Hoore; Niels Komen; Johan F Lange Journal: Colorectal Dis Date: 2021-11-07 Impact factor: 3.917
Authors: Sarah L Gans; Jasper J Atema; Susan van Dieren; Bas Groot Koerkamp; Marja A Boermeester Journal: Int J Colorectal Dis Date: 2015-05-03 Impact factor: 2.571
Authors: Marcin Zeman; Marek Czarnecki; Andrzej Chmielarz; Adam Idasiak; Maciej Grajek; Agnieszka Czarniecka Journal: World J Surg Oncol Date: 2020-08-14 Impact factor: 2.754