Literature DB >> 10085222

Identification of a Leu-lle internalization motif within the cytoplasmic domain of the leukaemia inhibitory factor receptor.

S Thiel1, I Behrmann, A Timmermann, H Dahmen, G Müller-Newen, F Schaper, J Tavernier, V Pitard, P C Heinrich, L Graeve.   

Abstract

Leukaemia inhibitory factor (LIF) signals via a heterodimeric receptor complex comprised of the LIF receptor (LIFR) and the interleukin (IL)-6 signal transducer gp130. Upon binding to its cognate receptor LIF is internalized. In this study, we show that the LIFR is endocytosed independently of gp130. By using a heterochimaeric receptor system we identified a dileucine-based internalization motif within the cytoplasmic domain of the LIFR. Our findings suggest that a heterodimeric LIFR/gp130 complex and homodimeric gp130/gp130 complex are endocytosed via distinct internalization signals.

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Year:  1999        PMID： 10085222      PMCID： PMC1220122     

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  22 in total

Review 1.  Leukemia inhibitory factor--a puzzling polyfunctional regulator.

Authors:  D Metcalf
Journal:  Growth Factors       Date:  1992       Impact factor: 2.511

2.  Identification of a region within the cytoplasmic domain of the interleukin-6 (IL-6) signal transducer gp130 important for ligand-induced endocytosis of the IL-6 receptor.

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Journal:  J Biol Chem       Date:  1994-07-22       Impact factor: 5.157

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Journal:  Gene       Date:  1994-11-18       Impact factor: 3.688

4.  Expression of human and murine interleukin-5 in eukaryotic systems.

Authors:  J Tavernier; R Devos; J Van der Heyden; G Hauquier; R Bauden; I Fache; E Kawashima; J Vandekerckhove; R Contreras; W Fiers
Journal:  DNA       Date:  1989-09

Review 5.  LIF: lots of interesting functions.

Authors:  D J Hilton
Journal:  Trends Biochem Sci       Date:  1992-02       Impact factor: 13.807

Review 6.  Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway.

Authors:  P C Heinrich; I Behrmann; G Müller-Newen; F Schaper; L Graeve
Journal:  Biochem J       Date:  1998-09-01       Impact factor: 3.857

7.  Proliferative responses and binding properties of hematopoietic cells transfected with low-affinity receptors for leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor.

Authors:  D P Gearing; S F Ziegler; M R Comeau; D Friend; B Thoma; D Cosman; L Park; B Mosley
Journal:  Proc Natl Acad Sci U S A       Date:  1994-02-01       Impact factor: 11.205

8.  Interleukin-6 signal transducer gp130 has specific binding sites for different cytokines as determined by antagonistic and agonistic anti-gp130 monoclonal antibodies.

Authors:  J Wijdenes; P C Heinrich; G Müller-Newen; C Roche; Z J Gu; C Clément; B Klein
Journal:  Eur J Immunol       Date:  1995-12       Impact factor: 5.532

9.  Specific binding of leukemia inhibitory factor to murine myoblasts in culture.

Authors:  J Bower; N Vakakis; N A Nicola; L Austin
Journal:  J Cell Physiol       Date:  1995-07       Impact factor: 6.384

10.  Structural requirements and sequence motifs for polarized sorting and endocytosis of LDL and Fc receptors in MDCK cells.

Authors:  K Matter; E M Yamamoto; I Mellman
Journal:  J Cell Biol       Date:  1994-08       Impact factor: 10.539
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  10 in total

1.  Sortilin facilitates signaling of ciliary neurotrophic factor and related helical type 1 cytokines targeting the gp130/leukemia inhibitory factor receptor beta heterodimer.

Authors:  Jakob Vejby Larsen; Maria Hansen; Bjarne Møller; Peder Madsen; Jürgen Scheller; Morten Nielsen; Claus Munck Petersen
Journal:  Mol Cell Biol       Date:  2010-06-28       Impact factor: 4.272

2.  Identification of a motif in the carboxyl terminus of CXCR2 that is involved in adaptin 2 binding and receptor internalization.

Authors:  G H Fan; W Yang; X J Wang; Q Qian; A Richmond
Journal:  Biochemistry       Date:  2001-01-23       Impact factor: 3.162

Review 3.  Principles of interleukin (IL)-6-type cytokine signalling and its regulation.

Authors:  Peter C Heinrich; Iris Behrmann; Serge Haan; Heike M Hermanns; Gerhard Müller-Newen; Fred Schaper
Journal:  Biochem J       Date:  2003-08-15       Impact factor: 3.857

4.  The tyrosine kinase Tyk2 controls IFNAR1 cell surface expression.

Authors:  Josiane Ragimbeau; Elisabetta Dondi; Andrés Alcover; Pierre Eid; Gilles Uzé; Sandra Pellegrini
Journal:  EMBO J       Date:  2003-02-03       Impact factor: 11.598

5.  Defective gp130-mediated signal transducer and activator of transcription (STAT) signaling results in degenerative joint disease, gastrointestinal ulceration, and failure of uterine implantation.

Authors:  M Ernst; M Inglese; P Waring; I K Campbell; S Bao; F J Clay; W S Alexander; I P Wicks; D M Tarlinton; U Novak; J K Heath; A R Dunn
Journal:  J Exp Med       Date:  2001-07-16       Impact factor: 14.307

Review 6.  Endosomes as Signaling Platforms for IL-6 Family Cytokine Receptors.

Authors:  Dirk Schmidt-Arras; Stefan Rose-John
Journal:  Front Cell Dev Biol       Date:  2021-06-01

7.  Evolution of Class I cytokine receptors.

Authors:  Clifford Liongue; Alister C Ward
Journal:  BMC Evol Biol       Date:  2007-07-18       Impact factor: 3.260

8.  Divergent pathways in COS-7 cells mediate defective internalization and intracellular routing of truncated G-CSFR forms in SCN/AML.

Authors:  Melissa G Hunter; Morgan McLemore; Daniel C Link; Megan Loveland; Alexander Copelan; Belinda R Avalos
Journal:  PLoS One       Date:  2008-06-18       Impact factor: 3.240

9.  Leukemia Inhibitory Factor Protects Neurons from Ischemic Damage via Upregulation of Superoxide Dismutase 3.

Authors:  Stephanie M Davis; Lisa A Collier; Christopher C Leonardo; Hilary A Seifert; Craig T Ajmo; Keith R Pennypacker
Journal:  Mol Neurobiol       Date:  2016-01-09       Impact factor: 5.590

10.  Orchestration of signaling by structural disorder in class 1 cytokine receptors.

Authors:  Pernille Seiffert; Katrine Bugge; Mads Nygaard; Gitte W Haxholm; Jacob H Martinsen; Martin N Pedersen; Lise Arleth; Wouter Boomsma; Birthe B Kragelund
Journal:  Cell Commun Signal       Date:  2020-08-24       Impact factor: 5.712
  10 in total

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