BACKGROUND: Cytogenetic, molecular cytogenetic, and molecular studies of prostate cancer have revealed an enormous amount of data regarding chromosomal loci that are aberrant in prostate tumors. METHODS: These data have been compared and condensed in this review to determine which chromosomes and chromosome sites have been most frequently reported. RESULTS: Loss of the Y chromosome, gain of 7, 8, and X, and interstitial deletions on 6q, 7q, 8p, 10q, 13q, 16q, 17q, and 18q are the most prevalent. CONCLUSIONS: A potential model for genetic control of tumor progression is presented, as are data regarding the evaluation of a new series of tumors.
BACKGROUND: Cytogenetic, molecular cytogenetic, and molecular studies of prostate cancer have revealed an enormous amount of data regarding chromosomal loci that are aberrant in prostate tumors. METHODS: These data have been compared and condensed in this review to determine which chromosomes and chromosome sites have been most frequently reported. RESULTS: Loss of the Y chromosome, gain of 7, 8, and X, and interstitial deletions on 6q, 7q, 8p, 10q, 13q, 16q, 17q, and 18q are the most prevalent. CONCLUSIONS: A potential model for genetic control of tumor progression is presented, as are data regarding the evaluation of a new series of tumors.
Authors: Ashish B Rajput; Melinda A Miller; Alessandro De Luca; Niki Boyd; Sam Leung; Antonio Hurtado-Coll; Ladan Fazli; Edward C Jones; Jodie B Palmer; Martin E Gleave; Michael E Cox; David G Huntsman Journal: J Clin Pathol Date: 2007-01-26 Impact factor: 3.411
Authors: J C Alers; P J Krijtenburg; A N Vis; R F Hoedemaeker; M F Wildhagen; W C Hop; T T van Der Kwast; F H Schröder; H J Tanke; H van Dekken Journal: Am J Pathol Date: 2001-02 Impact factor: 4.307
Authors: Lisa A Cannon-Albright; James M Farnham; Matthew Bailey; Frederick S Albright; Craig C Teerlink; Neeraj Agarwal; Robert A Stephenson; Alun Thomas Journal: Prostate Date: 2014-05-06 Impact factor: 4.104
Authors: Zhaoming Wang; Hemang Parikh; Jinping Jia; Timothy Myers; Meredith Yeager; Kevin B Jacobs; Amy Hutchinson; Laurie Burdett; Arpita Ghosh; Michael J Thun; Susan M Gapstur; W Ryan Diver; Jarmo Virtamo; Demetrius Albanes; Geraldine Cancel-Tassin; Antoine Valeri; Olivier Cussenot; Kenneth Offit; Ed Giovannucci; Jing Ma; Meir J Stampfer; J Michael Gaziano; David J Hunter; Ana Dutra-Clarke; Tomas Kirchhoff; Michael Alavanja; Laura B Freeman; Stella Koutros; Robert Hoover; Sonja I Berndt; Richard B Hayes; Ilir Agalliu; Robert D Burk; Sholom Wacholder; Gilles Thomas; Laufey Amundadottir Journal: Hum Genet Date: 2012-01-24 Impact factor: 4.132