BACKGROUND: A Y chromosomal role in prostate cancer has previously been suggested by both cytogenetic findings and patterns of Y chromosomal gene expression. We took advantage of the well established and stable phylogeny of the non-recombining segment of the Y chromosome to investigate the association between Y chromosomal DNA variation and prostate cancer risk. METHODS: We examined the distribution of 116 Y lineages in 930 prostate cancer cases and 1208 controls from four ethnic groups from a cohort study in Hawaii and California. RESULTS: One lineage, found only among the Japanese group in our study, was associated with a statistically significant predisposition to prostate cancer (odds ratio (OR) = 1.63; 95% confidence interval (CI) 1.07 to 2.47), and, in particular, to high severity disease in younger individuals (OR = 3.89; 95% CI 1.34 to 11.31). CONCLUSIONS: This finding suggests that a Y chromosomal factor contributes significantly to the development of prostate cancer in Japanese men.
BACKGROUND: A Y chromosomal role in prostate cancer has previously been suggested by both cytogenetic findings and patterns of Y chromosomal gene expression. We took advantage of the well established and stable phylogeny of the non-recombining segment of the Y chromosome to investigate the association between Y chromosomal DNA variation and prostate cancer risk. METHODS: We examined the distribution of 116 Y lineages in 930 prostate cancer cases and 1208 controls from four ethnic groups from a cohort study in Hawaii and California. RESULTS: One lineage, found only among the Japanese group in our study, was associated with a statistically significant predisposition to prostate cancer (odds ratio (OR) = 1.63; 95% confidence interval (CI) 1.07 to 2.47), and, in particular, to high severity disease in younger individuals (OR = 3.89; 95% CI 1.34 to 11.31). CONCLUSIONS: This finding suggests that a Y chromosomal factor contributes significantly to the development of prostate cancer in Japanese men.
Authors: Helen Skaletsky; Tomoko Kuroda-Kawaguchi; Patrick J Minx; Holland S Cordum; LaDeana Hillier; Laura G Brown; Sjoerd Repping; Tatyana Pyntikova; Johar Ali; Tamberlyn Bieri; Asif Chinwalla; Andrew Delehaunty; Kim Delehaunty; Hui Du; Ginger Fewell; Lucinda Fulton; Robert Fulton; Tina Graves; Shun-Fang Hou; Philip Latrielle; Shawn Leonard; Elaine Mardis; Rachel Maupin; John McPherson; Tracie Miner; William Nash; Christine Nguyen; Philip Ozersky; Kymberlie Pepin; Susan Rock; Tracy Rohlfing; Kelsi Scott; Brian Schultz; Cindy Strong; Aye Tin-Wollam; Shiaw-Pyng Yang; Robert H Waterston; Richard K Wilson; Steve Rozen; David C Page Journal: Nature Date: 2003-06-19 Impact factor: 49.962
Authors: P A Underhill; P Shen; A A Lin; L Jin; G Passarino; W H Yang; E Kauffman; B Bonné-Tamir; J Bertranpetit; P Francalacci; M Ibrahim; T Jenkins; J R Kidd; S Q Mehdi; M T Seielstad; R S Wells; A Piazza; R W Davis; M W Feldman; L L Cavalli-Sforza; P J Oefner Journal: Nat Genet Date: 2000-11 Impact factor: 38.330
Authors: M S Aly; P Dal Cin; W Van de Voorde; H van Poppel; F Ameye; L Baert; H Van den Berghe Journal: Genes Chromosomes Cancer Date: 1994-04 Impact factor: 5.006
Authors: Zhaoming Wang; Hemang Parikh; Jinping Jia; Timothy Myers; Meredith Yeager; Kevin B Jacobs; Amy Hutchinson; Laurie Burdett; Arpita Ghosh; Michael J Thun; Susan M Gapstur; W Ryan Diver; Jarmo Virtamo; Demetrius Albanes; Geraldine Cancel-Tassin; Antoine Valeri; Olivier Cussenot; Kenneth Offit; Ed Giovannucci; Jing Ma; Meir J Stampfer; J Michael Gaziano; David J Hunter; Ana Dutra-Clarke; Tomas Kirchhoff; Michael Alavanja; Laura B Freeman; Stella Koutros; Robert Hoover; Sonja I Berndt; Richard B Hayes; Ilir Agalliu; Robert D Burk; Sholom Wacholder; Gilles Thomas; Laufey Amundadottir Journal: Hum Genet Date: 2012-01-24 Impact factor: 4.132